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公开(公告)号：US12110535B2
公开(公告)日：2024-10-08
申请号：US18385300
申请日：2023-10-30
Applicant: Gen-Probe Incorporated
Inventor： David A. Buse , Norbert D. Hagen , David Opalsky
IPC: C12Q1/6806 , B01L3/00 , B01L7/00 , C12Q1/686 , G01N35/04
CPC classification number: C12Q1/6806 , B01L3/50825 , B01L3/565 , B01L7/5255 , C12Q1/686 , G01N35/04 , B01L3/527 , B01L2200/026 , B01L2200/0689 , B01L2300/046 , G01N2035/0418 , G01N2035/0436
Abstract: A method for reconstituting a reagent within a reagent pack including one or more wells and at least one of the wells containing a lyophilized reagent comprises the steps of receiving reagent packs into a reagent pack input carousel, transferring one reagent pack with a rotary distributor from the input carousel to a reagent pack storage carousel, retrieving the reagent pack from the storage carousel with the rotary distributor and placing the reagent pack into a reagent pack loading station, and dispensing a reconstitution reagent with an automated pipettor into the well containing the lyophilized reagent to form a reconstituted reagent.
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公开(公告)号：US20240269679A1
公开(公告)日：2024-08-15
申请号：US18441568
申请日：2024-02-14
Applicant: Singh Instrument LLC
Inventor： Robbie Singh Sidhu , Eric Dias , John Flexer Walzer, JR. , Richard Fisher
CPC classification number: B01L3/565 , B01L9/065 , B01L2300/045 , B01L2300/08 , B01L2400/043
Abstract: A small scale reactor includes a seal gate for closing an interior of a test cell in the reactor. The seal gate protects elastomeric seals in an injection port from the effluent from the test cell. A stirrer of the small scale reactor has a clip on magnet that allows for easy replacement. A drive system of the small scale reactor does not have to be disconnected when the test cells are opened to permit access for placing or retrieving the vials in the reactor.
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3.发明公开公开(公告)号：US20240192201A1
公开(公告)日：2024-06-13
申请号：US18457309
申请日：2023-08-28
Applicant: TianJin University
CPC classification number: G01N33/53 , B01L3/563 , B01L3/565 , G01N21/03 , G01N21/6486 , G01N33/68 , B01L2300/043 , B01L2300/0663 , B01L2300/0681 , G01N2333/58
Abstract: The present invention discloses a BNP aptamer fluorescence detection device based on a smart phone and a sensing method thereof, including a detection control mechanism, a fluorescence rapid detection mechanism and an aptamer fluorescence sensor. The aptamer fluorescence sensor uses oligonucleotides marked by carboxy fluorescein as an aptamer to capture the BNP specificity. The detection control mechanism receives a fluorescence signal to display test results. The fluorescence rapid detection mechanism uses the OTG function as a plug-in power supply. The present invention fills the gap of portable fluorescence detection for digital BNP.
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公开(公告)号：US20240060114A1
公开(公告)日：2024-02-22
申请号：US18385300
申请日：2023-10-30
Applicant: Gen-Probe Incorporated
Inventor： David A. BUSE , Norbert D. Hagen , David Opalsky
IPC: C12Q1/6806 , G01N35/04 , B01L3/00 , B01L7/00 , C12Q1/686
CPC classification number: C12Q1/6806 , G01N35/04 , B01L3/50825 , B01L3/565 , B01L7/5255 , C12Q1/686 , G01N2035/0418 , G01N2035/0436 , B01L3/527 , B01L2200/026 , B01L2200/0689 , B01L2300/046
Abstract: A method for reconstituting a reagent within a reagent pack including one or more wells and at least one of the wells containing a lyophilized reagent comprises the steps of receiving reagent packs into a reagent pack input carousel, transferring one reagent pack with a rotary distributor from the input carousel to a reagent pack storage carousel, retrieving the reagent pack from the storage carousel with the rotary distributor and placing the reagent pack into a reagent pack loading station, and dispensing a reconstitution reagent with an automated pipettor into the well containing the lyophilized reagent to form a reconstituted reagent.
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公开(公告)号：US11679382B2
公开(公告)日：2023-06-20
申请号：US16971665
申请日：2019-03-08
Applicant: WUHAN EDEBIO TECHNOLOGY LLC.
Inventor： Chuli Yi
CPC classification number: B01L3/021 , B01F27/806 , B01L3/52 , B01L3/565 , B01L3/567 , B01L9/523 , C12N15/1017 , G01N35/1002 , B01L2200/16 , B01L2300/042 , B01L2300/0618 , B01L2300/14 , B01L2400/0487 , B01L2400/082 , G01N35/1009 , G01N35/1011 , G01N35/1074
Abstract: A nucleic acid extraction system, comprising: a nucleic acid extraction plate, and a pipetting device and positive pressure device that are arranged side by side, the pipetting device comprising: an infusion device, an infusion device mounting frame, an infusion device driving unit, and a plurality of infusion units, each of the infusion units comprising: a reagent supply device and a reagent flow controller; the positive pressure device comprises: a plug, an air pipe, a positive pressure provider and a positive pressure driving device. The nucleic acid extraction system is highly efficiency and low-cost when extracting nucleic acid.
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Patent Agency Ranking
公开(公告)号：US20180311670A1
公开(公告)日：2018-11-01
申请号：US15772162
申请日：2016-11-30
Applicant: Biocartis NV
Inventor： Nicolas Vergauwe , Frederik Doucet , Thierry Tollenboom
IPC: B01L3/00
CPC classification number: B01L3/565 , B01L3/502715 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2400/0677
Abstract: A device for sealing liquids inside a selected zone of a fluidic path that runs in a fluidic assembly and then for cutting or removing the thus sealed zone in a spillage- and contamination-free manner from said fluidic assembly. Methods of performing such contamination- and leakage-free sealing and cutting of selected fluidic path zones comprising a liquid of interest from the remaining parts of fluidic assemblies, preferably in a fully automated manner.
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公开(公告)号：US10052627B2
公开(公告)日：2018-08-21
申请号：US15029154
申请日：2014-09-10
Applicant: Endress + Hauser Flowtec AG
Inventor： Christof Huber , Hagen Feth , Frank Steinhoff , Holger Reinecke
CPC classification number: B01L3/502 , B01L3/502715 , B01L3/565 , B01L9/52 , B01L2200/026 , B01L2200/0689 , B01L2300/0627 , B01L2300/0645 , B01L2300/0832 , B01L2300/0887 , B01L2300/12 , G01D11/30 , G01N2030/6013
Abstract: A measuring arrangement comprising: a support element having a longitudinal axis, wherein a sensor for ascertaining a process variable of a gaseous or liquid fluid is arranged on the support element; and the sensor, wherein the sensor has a fluid duct, which extends within the sensor. The support element has a fluid duct, and for mechanical connection of the fluid duct with the fluid duct of the sensor a bonding layer, which extends over a portion of a surface of the support element and over a portion of a surface of the sensor. The bonding layer comprises at least one fluorinated polymer. The support element has for connection of the fluid duct of the support element with the fluid duct of the sensor, in each case, at least one connection element, which protrude from the support element perpendicularly to the longitudinal axis and which protrude inwardly into the fluid duct of the sensor. The connection elements are secured at least to a the sensor by means of a bonding layer, and wherein the bonding layer comprises a fluorinated polymer.
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公开(公告)号：US20180080020A1
公开(公告)日：2018-03-22
申请号：US15694108
申请日：2017-09-01
Applicant: Raindance Technologies, Inc.
Inventor： Darren Roy Link , Laurent Boitard , Jeffrey Branciforte , Yves Charles , Gilbert Feke , John Q. Lu , David Marran , Ahmadali Tabatabai , Michael Weiner , Wolfgang Hinz , Jonathan M. Rothberg
IPC: C12N15/10 , G01N33/68 , B01F13/00 , G01N33/543 , G01N33/536 , C40B70/00 , C40B60/12 , C40B60/08 , C40B50/08 , C40B40/04 , C40B30/04 , C12Q1/68 , C07K1/04 , B82Y30/00 , B82Y5/00 , B01L3/00 , B01J19/00 , G01N33/542 , G01N21/64 , B01L7/00 , B01F3/08
CPC classification number: B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12N15/1075 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
Abstract: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library.
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公开(公告)号：US09803239B2
公开(公告)日：2017-10-31
申请号：US13840482
申请日：2013-03-15
Applicant: Complete Genomics, Inc.
Inventor： Bill J. Peck , Mark Fuller , Daniel West , Anthony Delacruz
CPC classification number: C12Q1/6874 , B01L3/502715 , B01L3/502723 , B01L3/565 , B01L2200/027 , B01L2200/0684 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , G01N21/05
Abstract: Biochemical flow cells having sealed inlets and outlets are provided for performing high-volume assays on macromolecules. In one example embodiment, a flow cell with detachable inlet and outlet connectors comprises an inlet manifold, a coverslip, and a substrate disposed below the coverslip to form a reaction chamber, where the substrate is disposed to partially cover the inlet manifold such that a slit is formed along an entire edge of the substrate where fluids can flow from the inlet manifold through the slit, around substantially the entire edge of the substrate, and into the reaction chamber at equalized pressure and without bubbles. In another embodiment, a flow cell comprises an outlet manifold, two or more flow regions each connected to its own loading port via its own flow distribution funnel, each loading port connected to the outlet manifold, and plugs in a wall of the outlet manifold opposite each loading port, such that when a plug is absent from the wall of the outlet manifold, a loading tip may be inserted in its place, passing through the outlet manifold and connecting directly to a loading port.
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公开(公告)号：US20170188572A1
公开(公告)日：2017-07-06
申请号：US15463771
申请日：2017-03-20
Applicant: Francesca Dagny TEKULA
Inventor： Francesca Dagny TEKULA
CPC classification number: A01N1/0263 , A01N1/0273 , A61B10/0096 , B01F13/0023 , B01L3/502 , B01L3/561 , B01L3/563 , B01L3/565 , B01L2200/025 , B01L2200/026 , B01L2200/028 , B01L2200/0689 , B01L2200/087 , B01L2200/18 , B01L2300/028 , B01L2300/042 , B01L2300/0832 , B01L2300/087 , B01L2400/0478
Abstract: A specimen container for use with biological specimens that includes at least one cylindrical housing, wherein the at least one cylindrical housing is open on one or both ends thereof; at least one cap for sealing the open ends of the at least one cylindrical housing; a syringe plunger adapted for insertion into the at least one cylindrical housing, wherein the syringe plunger is operative to move a biological specimen into the at least one cylindrical housing when the syringe plunger is depressed; and optionally, a linking cuff, wherein the linking cuff is operative to join multiple cylindrical housings to one another and permit mixing of the contents thereof.
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