-
公开(公告)号：US10139411B2
公开(公告)日：2018-11-27
申请号：US15415290
申请日：2017-01-25
Applicant: Raindance Technologies, Inc.
Inventor： Darren Roy Link , Michael L. Samuels
IPC: G01N33/58 , G01N33/573 , B01F5/06 , B01J19/00 , B01F13/00 , B01L3/00 , B01F3/08 , C40B40/04 , C40B50/08 , C40B60/10 , G01N33/50 , C12Q1/25 , C12Q1/6804 , C12Q1/6818 , C12Q1/6827 , G01N33/542 , B01L7/00 , G01N21/64
Abstract: The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number.
-
公开(公告)号：US09944977B2
公开(公告)日：2018-04-17
申请号：US14568923
申请日：2014-12-12
Applicant: Raindance Technologies, Inc.
Inventor： Darren R. Link , Michael Samuels
CPC classification number: C12Q1/6844 , C12Q1/6858 , C12Q2535/122 , C12Q2563/159 , C12Q2563/179 , C12Q2565/629
Abstract: The invention generally relates to methods for distinguishing a rare genetic variation in a nucleic acid sequence.
-
公开(公告)号：US20180080020A1
公开(公告)日：2018-03-22
申请号：US15694108
申请日：2017-09-01
Applicant: Raindance Technologies, Inc.
Inventor： Darren Roy Link , Laurent Boitard , Jeffrey Branciforte , Yves Charles , Gilbert Feke , John Q. Lu , David Marran , Ahmadali Tabatabai , Michael Weiner , Wolfgang Hinz , Jonathan M. Rothberg
IPC: C12N15/10 , G01N33/68 , B01F13/00 , G01N33/543 , G01N33/536 , C40B70/00 , C40B60/12 , C40B60/08 , C40B50/08 , C40B40/04 , C40B30/04 , C12Q1/68 , C07K1/04 , B82Y30/00 , B82Y5/00 , B01L3/00 , B01J19/00 , G01N33/542 , G01N21/64 , B01L7/00 , B01F3/08
CPC classification number: B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12N15/1075 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
Abstract: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library.
-
公开(公告)号：US20180057863A1
公开(公告)日：2018-03-01
申请号：US15688250
申请日：2017-08-28
Applicant: Raindance Technologies, Inc.
Inventor： Jonathan William Larson , Qun Zhong , Darren Roy Link
IPC: C12Q1/68
CPC classification number: C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
-
公开(公告)号：US09733168B2
公开(公告)日：2017-08-15
申请号：US15082424
申请日：2016-03-28
Applicant: Raindance Technologies, Inc.
Inventor： Benjamin Miller , Brian Hutchison , Andrew Wilson , Jonathan William Larson , Qun Zhong , Yevgeny Yurkovetsky , Darren Link , Mark Weary
CPC classification number: G01N1/38 , B01L3/0241 , B01L3/502715 , B01L3/502784 , B01L2200/061 , B01L2200/0673 , B01L2200/143 , B01L2300/0877 , F16K99/0001 , F16K2099/0084 , F17D3/01 , G01N27/44791 , G01N2021/0353 , Y10T137/2185 , Y10T137/7761 , Y10T137/8158 , Y10T137/8593 , Y10T436/118339
Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
-
Patent Agency Ranking
6.发明授权Microfluidic devices and methods of use in the formation and control of nanoreactors 有权微流体装置和用于形成和控制纳米反应器的方法公开(公告)号：US09534216B2
公开(公告)日：2017-01-03
申请号：US14248991
申请日：2014-04-09
Applicant: Raindance Technologies, Inc.
Inventor： Darren R. Link , Laurent Boitard , Jeffrey Branciforte , Yves Charles , Gilbert Feke , John Q. Lu , David Marran , Ahmadali Tabatabai , Michael Weiner , Wolfgang Hinz , Jonathan M. Rothberg
IPC: G01N15/10 , C12Q1/68 , G01N21/00 , G01N21/21 , C12N15/10 , B01F13/00 , B01J19/00 , B82Y5/00 , B82Y30/00 , C07K1/04 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N33/536 , G01N33/68 , G01N33/543 , G01N33/50 , G01N33/00 , B01L3/00 , B01F3/08 , G01N33/542 , G01N21/64 , B01L7/00
CPC classification number: C12N15/1075 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
Abstract: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library.
Abstract translation: 本发明提供了可用于进行高通量筛选测定和组合化学的新型微流体装置和方法。 本发明提供了含有唯一标记的细胞，酶，核酸等的含水基乳液，其中乳液还包含引物，标记，探针和其它反应物。 油基载体流体在微流体装置上包封乳剂库，使得连续通道提供不混溶流体的流动，以实现乳液库的汇集，聚结，混合，分选，检测等。
-
公开(公告)号：US20160222433A1
公开(公告)日：2016-08-04
申请号：US15019355
申请日：2016-02-09
Applicant: Raindance Technologies, Inc.
Inventor： Jonathan William Larson , Qun Zhong , Darren R. Link
IPC: C12Q1/68
CPC classification number: C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
-
公开(公告)号：US09366632B2
公开(公告)日：2016-06-14
申请号：US13866126
申请日：2013-04-19
Applicant: Raindance Technologies, Inc.
Inventor： Darren R. Link , Qun Zhong , Andrew Watson
CPC classification number: G01N21/6486 , C12Q1/686 , C12Q2563/159 , C12Q2565/629
Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
-
9.发明申请公开(公告)号：US20150167066A1
公开(公告)日：2015-06-18
申请号：US14568923
申请日：2014-12-12
Applicant: Raindance Technologies, Inc.
Inventor： Darren R. Link , Michael Samuels
IPC: C12Q1/68
CPC classification number: C12Q1/6844 , C12Q1/6858 , C12Q2535/122 , C12Q2563/159 , C12Q2563/179 , C12Q2565/629
Abstract: The invention generally relates to methods for distinguishing a rare genetic variation in a nucleic acid sequence.
Abstract translation: 本发明一般涉及区分核酸序列中罕见遗传变异的方法。
-
公开(公告)号：US20150027892A1
公开(公告)日：2015-01-29
申请号：US14511892
申请日：2014-10-10
Applicant: Raindance Technologies, Inc.
Inventor： Benjamin J. Miller , John Brian Hutchison , Andrew Wilson , Jonathan William Larson , Qun Zhong , Yevgeny Yurkovetsky , Darren R. Link , Mark Weary
IPC: G01N27/447
CPC classification number: G01N1/38 , B01L3/0241 , B01L3/502715 , B01L3/502784 , B01L2200/061 , B01L2200/0673 , B01L2200/143 , B01L2300/0877 , F16K99/0001 , F16K2099/0084 , F17D3/01 , G01N27/44791 , G01N2021/0353 , Y10T137/2185 , Y10T137/7761 , Y10T137/8158 , Y10T137/8593 , Y10T436/118339
Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
Abstract translation: 本发明提供了用于评估微流体通道内的微流体液滴的一个或多个预定特征或性质的方法，以及调节该通道内的一个或多个流体流速以使用反馈控制选择性地改变预定微滴特性或特性。
-
-
-
-
-
-
-
-
-
Search Results
66
records
(took 0.047 seconds)
