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公开(公告)号：US11966086B2
公开(公告)日：2024-04-23
申请号：US17830115
申请日：2022-06-01
发明人： David Buse , David Howard Combs , Norbert D. Hagen , David Opalsky , Bruce Richardson , Anita Prasad , Keith Moravick , Tyler Moore
CPC分类号： G02B6/3668 , G01N21/253 , G01N21/6452 , G02B6/06 , G02B6/08 , G02B6/3672 , G02B6/4214 , G02B6/4246 , G02B6/4269 , G01N2021/6484
摘要： A first time/temperature data set includes temperatures and time stamps recorded at time intervals during a first thermal cycling process and a time stamp for each time interval, and a second time/temperature data set includes temperatures and time stamps recorded at time intervals during a second thermal cycling process. Signal emissions at different signal detecting positions are sequentially measured at different time intervals to generate first and second time/signal emission data sets for receptacles subject to the first and second thermal cycling processes, respectively. Signal emissions of receptacles subject to the first thermal cycling process are synchronized with specific temperatures of the first thermal cycling process by comparing time stamps of the first time/signal emission data set for each receptacle with the time stamps of the first time/temperature data set that correspond with the specific temperature. Signal emissions of receptacles subject to the second thermal cycling process are synchronized with specific temperatures of the second thermal cycling process by comparing time stamps of the second time/signal emission data set for each receptacle with the time stamps of the second time/temperature data set that correspond with the specific temperature.
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公开(公告)号：US11840727B2
公开(公告)日：2023-12-12
申请号：US17028367
申请日：2020-09-22
发明人： David Buse , David Howard Combs , Norbert D. Hagen , David Opalsky , Bruce Richardson , Anita Prasad , Keith Moravick , Tyler Moore , Byron J. Knight
CPC分类号： C12Q1/686 , B01L7/52 , G01N21/6452 , B01L9/06 , B01L2200/141 , B01L2200/142 , B01L2300/042 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , B01L2300/1822 , G01N2021/6482 , G01N2021/6484
摘要： Multiple receptacles containing a reaction mixture are transported to corresponding receptacle wells of a thermally-conductive receptacle holder in thermal communication with a support that is in thermal communication with a heat sink. The heat sink is pre-heated to a temperature above ambient temperature, and the temperature of the receptacle holder is cycled. Optical communication is established between each of the receptacle wells and an excitation signal source and an emission signal detector during cycling, and whether an emission signal is emitted from any of the receptacles is determined as an indication of the presence of a target nucleic acid.
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公开(公告)号：US11746373B2
公开(公告)日：2023-09-05
申请号：US17847096
申请日：2022-06-22
发明人： Byron J. Knight , David A. Buse , Norbert D. Hagen , David Opalsky , Tyler Moore , Anita Prasad , Bruce Richardson
IPC分类号： B01L3/00 , B01L7/00 , G01N35/04 , C12Q1/6806 , C12Q1/686
CPC分类号： C12Q1/6806 , B01L3/50825 , B01L3/565 , B01L7/5255 , C12Q1/686 , G01N35/04 , B01L3/527 , B01L2200/026 , B01L2200/0689 , B01L2300/046 , G01N2035/0418 , G01N2035/0436
摘要： A cap and a processing vial configured for interlocking engagement. The processing vial includes a locking collar surrounding an open upper end of the processing vial with lateral through holes formed through the locking collar. The vial also includes a latch hook located above each through hole. The cap includes a latch collar extending about a lower portion of the cap, where the latch collar is configured to snap in beneath the latch hooks of the processing vial when the lower portion of the cap is inserted into the open upper end of the processing vial to lock the cap to the processing vial.
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公开(公告)号：US11493445B2
公开(公告)日：2022-11-08
申请号：US16910414
申请日：2020-06-24
发明人： Haitao Li , David Opalsky , R. Eric Heinz , Norbert D. Hagen
摘要： A system for monitoring reactions with a plurality of receptacle vessels that includes: an incubator; a movable receptacle carrier contained within a temperature-controlled chamber of the incubator; one or more fixed fluorometers configured to measure a fluorescent emission and positioned with respect to the receptacle carrier to measure fluorescent emissions from receptacle vessels carried on the receptacle carrier into an operative position with respect to each fluorometer; one or more fluorescent reference standards mounted on the receptacle carrier; and a controller configured to control operation of the receptacle carrier and the one or more fluorometers to determine if a fluorescent emission intensity of one or more of the fluorescent reference standards deviates from an expected fluorescent emission intensity.
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公开(公告)号：US20220291454A1
公开(公告)日：2022-09-15
申请号：US17830115
申请日：2022-06-01
发明人： David Buse , David Combs , Norbert D. Hagen , David Opalsky , Bruce Richardson , Anita Prasad , Keith Moravick , Tyler Moore
摘要： A first time/temperature data set includes temperatures and time stamps recorded at time intervals during a first thermal cycling process and a time stamp for each time interval, and a second time/temperature data set includes temperatures and time stamps recorded at time intervals during a second thermal cycling process. Signal emissions at different signal detecting positions are sequentially measured at different time intervals to generate first and second time/signal emission data sets for receptacles subject to the first and second thermal cycling processes, respectively. Signal emissions of receptacles subject to the first thermal cycling process are synchronized with specific temperatures of the first thermal cycling process by comparing time stamps of the first time/signal emission data set for each receptacle with the time stamps of the first time/temperature data set that correspond with the specific temperature. Signal emissions of receptacles subject to the second thermal cycling process are synchronized with specific temperatures of the second thermal cycling process by comparing time stamps of the second time/signal emission data set for each receptacle with the time stamps of the second time/temperature data set that correspond with the specific temperature.
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公开(公告)号：US11009458B2
公开(公告)日：2021-05-18
申请号：US16658482
申请日：2019-10-21
摘要： Optical reference devices for calibrating or monitoring the performance of an optical measurement device, such as a fluorometer, are made from thermoplastics from the polyaryletherketone (PAEK) family of semi-crystalline thermoplastics, including polyether ether ketone (PEEK). The reference device may be made as a master reference device having a known emission output—as determined by a standard optical measurement device—that is used to calibrate other optical measurement devices against the standard. The reference device may be made in the shape of a receptacle vial so that the reference device can be placed in the receptacle holding structure of an instrument in which the optical measurement device is installed and used to calibrate or monitor the optical measurement device within the instrument. The reference device may be part of the probe of a pipettor or pick and place mechanism or it may be a cap that can be secured to the end of such a probe.
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公开(公告)号：US10451550B2
公开(公告)日：2019-10-22
申请号：US15176861
申请日：2016-06-08
摘要： Optical reference devices for calibrating or monitoring the performance of an optical measurement device, such as a fluorometer, are made from thermoplastics from the polyaryletherketone (PAEK) family of semi-crystalline thermoplastics, including polyether ether ketone (PEEK). The reference device may be made as a master reference device having a known emission output—as determined by a standard optical measurement device—that is used to calibrate other optical measurement devices against the standard. The reference device may be made in the shape of a receptacle vial so that the reference device can be placed in the receptacle holding structure of an instrument in which the optical measurement device is installed and used to calibrate or monitor the optical measurement device within the instrument. The reference device may be part of the probe of a pipettor or pick and place mechanism or it may be a cap that can be secured to the end of such a probe.
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公开(公告)号：US09732374B2
公开(公告)日：2017-08-15
申请号：US14213900
申请日：2014-03-14
CPC分类号： C12Q1/6806 , B01L3/50825 , B01L3/527 , B01L3/565 , B01L7/5255 , B01L2200/026 , B01L2200/0689 , B01L2300/046 , C12Q1/686 , G01N35/04 , G01N2035/0418 , G01N2035/0436
摘要： A diagnostic system performs a first nucleic acid amplification reaction and a second, different nucleic acid amplification reaction. The diagnostic system includes a compartment configured to store at least a first bulk reagent container comprising a first bulk reagent for performing a sample preparation process, and a second bulk reagent container comprising a second bulk reagent for performing the first reaction. The system including a compartment configured to store at least one unit-dose pack comprising a plurality of unit-dose reagents for performing the second reaction. The diagnostic system is configured to perform the sample preparation process using the first bulk reagent on each of a plurality of samples provided to the diagnostic system. The system is configured to perform the first reaction using the second bulk reagent on a first sample subset, and perform the second reaction using the plurality of first unit-dose reagents on a second sample subset.
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9.发明授权Apparatus for transferring reaction receptacles between a plurality of receptacle-receiving structures 有权用于在多个容器接收结构之间转移反应容器的装置公开(公告)号：US09446911B2
公开(公告)日：2016-09-20
申请号：US14259041
申请日：2014-04-22
发明人： Stefan Habrich , Norbert D. Hagen , Olaf Hörger , Byron J. Knight , David Opalsky , Jason F. Rhubottom , Heiko Sayer , Harald Thahedl
CPC分类号： B65G47/901 , G01N35/026 , G01N35/04 , G01N2035/0413 , G01N2035/0422 , G01N2035/0484
摘要： An apparatus for transferring receptacles between a plurality of receptacle-receiving structures disposed at different locations adjacent a transport track. The apparatus includes a receptacle carrier operatively engaged with the transport track and adapted to carry a receptacle and translate along the transport track. The receptacle carrier is further adapted to selectively stop at a transfer station with respect to any of the receptacles-receiving structures. The receptacle carrier includes a receptacle moving mechanism adapted to move a receptacle with respect to the receptacle carrier to move a receptacle into and/or out of the receptacle carrier. The apparatus further includes a transfer position locating system to automatically determine a location of a transfer position of the receptacle carrier with respect to each of the receptacle-receiving structures, thereby enabling the receptacle carrier to transfer a receptacle between the receptacle carrier and the receptacle-receiving structures.
摘要翻译： 一种用于在设置在邻近传输轨道的不同位置处的多个插座接收结构之间传送插座的装置。 该装置包括与运输轨道可操作地接合并适于承载容器并沿着运输轨道平移的插座托架。 插座托架进一步适于相对于任何容器接收结构选择性地停在转运站。 插座托架包括插座移动机构，其适于使插座相对于插座托架移动以将插座移入和/或离开插座托架。 该装置还包括传送位置定位系统，用于相对于每个容器接收结构自动确定插座托架的传送位置的位置，从而使得插座托架能够在插座托架和插座接收结构之间传送插座， 接收结构。
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公开(公告)号：US09117192B2
公开(公告)日：2015-08-25
申请号：US14229676
申请日：2014-03-28
发明人： Craig B. Clark , John M. Gilker , Norbert D. Hagen , Olaf Hörger , Tom R. Horn , Byron J. Knight , Waldemar Lukhaub , David Opalsky , Jason F. Rhubottom
CPC分类号： G06Q10/087 , B01L9/06 , B01L2200/023 , B01L2200/06 , B01L2200/141 , B01L2300/021 , G01N35/1004
摘要： A structure for holding sample-containing receptacles includes a cover with holes formed therein through which the receptacles can be accessed with a substance transfer mechanism, such as a robotic pipettor. When the transfer mechanism is inserted into and then withdrawn from a receptacle, a string of viscous material may be suspended from the mechanism. A viscous string removal element adjacent each opening engages the string of viscous material and dislodges the string from the mechanism when the mechanism moves in a prescribed path with respect to the removal element. A sample rack configured to hold receptacles and to be inserted into the structure below the cover includes a sample rack having receptacle-receiving pockets, each with a resilient element and a positioning feature for holding receptacles of varying sizes in a predetermined position within the receptacle receiving pocket, and a cover including features for preventing a receptacle from being pulled out of its receptacle-receiving pocket when the transfer mechanism is withdrawn from the receptacle.
摘要翻译： 用于保持含有样品的容器的结构包括其中形成有孔的盖，通过该盖可以用诸如机器人移液器的物质转移机构接近容器。 当转移机构插入到容器中然后从容器中取出时，一串粘性材料可以悬挂在机构上。 邻近每个开口的粘性排除元件与该粘性材料串接合，并且当机构相对于移除元件以规定的路径移动时，将该绳从机构中移出。 被配置成保持插座并插入到盖子下面的结构中的样品架包括具有插座容纳凹部的样品架，每个具有弹性元件和用于在插座接收中的预定位置保持不同尺寸的容器的定位特征 口袋和盖子，其包括当传送机构从容器中取出时防止插座从其容器接收口袋中被拉出的特征。
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