公开(公告)号：US11493445B2

公开(公告)日：2022-11-08

申请号：US16910414

申请日：2020-06-24

申请人： Gen-Probe Incorporated

发明人： Haitao Li ,  David Opalsky ,  R. Eric Heinz ,  Norbert D. Hagen

IPC分类号： G01N21/64 ,  G01N21/27

摘要： A system for monitoring reactions with a plurality of receptacle vessels that includes: an incubator; a movable receptacle carrier contained within a temperature-controlled chamber of the incubator; one or more fixed fluorometers configured to measure a fluorescent emission and positioned with respect to the receptacle carrier to measure fluorescent emissions from receptacle vessels carried on the receptacle carrier into an operative position with respect to each fluorometer; one or more fluorescent reference standards mounted on the receptacle carrier; and a controller configured to control operation of the receptacle carrier and the one or more fluorometers to determine if a fluorescent emission intensity of one or more of the fluorescent reference standards deviates from an expected fluorescent emission intensity.

公开(公告)号：US09945780B2

公开(公告)日：2018-04-17

申请号：US13912525

申请日：2013-06-07

申请人： GEN-PROBE INCORPORATED

发明人： Haitao Li ,  David Opalsky ,  R. Eric Heinz ,  Norbert D. Hagen

IPC分类号： G01N21/63 ,  G01N21/64 ,  G01N21/27 ,  G01N21/62 ,  G01N21/25

CPC分类号： G01N21/645 ,  G01N21/276

摘要： A System and method for self-checking a fluorometer for failure or deteriorated performance includes fluorescent reference standards mounted on a support to move with respect to one or more fixed fluorometers. The intensity of the fluorescent emission of the fluorescent reference standard is initially measured with the fluorometer, and, after a prescribed interval of usage of the fluorometer, a test measurement of the intensity of the fluorescent emission of the fluorescent standard is taken with the fluorometer. The test measurement is compared to the initial measurement, and failure or deteriorated performance of the fluorometer is determined based on a deviation of the test measurement from the initial measurement.

公开(公告)号：US10732112B2

公开(公告)日：2020-08-04

申请号：US15902657

申请日：2018-02-22

申请人： Gen-Probe Incorporated

发明人： Haitao Li ,  David Opalsky ,  R. Eric Heinz ,  Norbert D. Hagen

IPC分类号： G01J3/443 ,  G01N21/64 ,  G01N21/27 ,  G01J3/28

摘要： A system and method for self-checking a fluorometer for failure or deteriorated performance includes fluorescent reference standards mounted on a support to move with respect to one or more fixed fluorometers. The intensity of the fluorescent emission of the fluorescent reference standard is initially measured with the fluorometer, and, after a prescribed interval of usage of the fluorometer, a test measurement of the intensity of the fluorescent emission of the fluorescent standard is taken with the fluorometer. The test measurement is compared to the initial measurement, and failure or deteriorated performance of the fluorometer is determined based on a deviation of the test measurement from the initial measurement.