公开(公告)号：US10081005B2

公开(公告)日：2018-09-25

申请号：US14777973

申请日：2014-03-26

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Melissa Moore ,  R. Michael Van Dam ,  Kevin Quinn ,  Shane Claggett ,  Henry Herman ,  Mark Lazari

IPC分类号： B01J19/00 ,  B01J14/00 ,  C07H17/02

CPC分类号： B01J19/004 ,  B01J14/00 ,  B01J19/0093 ,  B01J2219/00799 ,  B01J2219/00801 ,  B01J2219/00813 ,  B01J2219/00815 ,  B01J2219/00817 ,  B01J2219/00831 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00909 ,  B01J2219/00918 ,  B01J2219/0097 ,  B01J2219/00986 ,  C07H17/02

摘要： An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the reactor assembly in the vertical direction. A plurality of disposable cassettes are disposed above each of the plurality of reactor assemblies, each cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the cassette. The device includes a three-axis reagent and gas handling robot disposed above the plurality of cassettes and terminates in a vial gripper and a gas manifold having an inert gas port and a vacuum port. The device includes a control system configured to control the horizontal actuator and vertical actuator of each reactor assembly and the three-axis reagent and gas handling robot.

公开(公告)号：US20180055070A1

公开(公告)日：2018-03-01

申请号：US15803115

申请日：2017-11-03

申请人： Advance International Inc.

发明人： Shahmard Maziar Ghorbani ,  Kerry Coltun

IPC分类号： A23J1/04 ,  A23D9/02 ,  C11B1/10

CPC分类号： A23J1/04 ,  A23D9/02 ,  B01D3/00 ,  B01D11/0288 ,  B01D35/02 ,  B01D36/00 ,  B01J19/0053 ,  B01J19/18 ,  B01J2219/00909 ,  B01J2219/0095 ,  C11B1/10

摘要： The present invention describes a method and an automatic system for recovering protein powder meal, crude and pure omega-3 oil and purified distilled water from a mixture of animal tissue processed in a filter-drier-reaction tank. Animal tissue, for example fish, and organic solvent are directly or indirectly fed into the filter-drier-reaction tank. The filter-drier-reaction tank mixes, heats, and separates solid and heavy liquid portions of the mixture, the organic solvents are automatically recycled back in to the system after distillation. The solid portion is retained in the filter-drier-reaction tank and baked. Solid protein powder product (the protein powder meal) is thus recovered.

公开(公告)号：US20160299047A1

公开(公告)日：2016-10-13

申请号：US15038324

申请日：2014-04-23

申请人： SCHLUMBERGER TECHNOLOGY CORPORATION

发明人： Shahnawaz Hossain Molla ,  Farshid Mostowfi ,  Heng-Joo Ng

IPC分类号： G01N11/08 ,  B01L3/00

CPC分类号： G01N11/08 ,  B01J19/0093 ,  B01J2219/00049 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00909 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00972 ,  B01J2219/00986 ,  B01L3/502784 ,  B01L3/502792 ,  B01L7/52 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0883 ,  B01L2300/14 ,  B01L2300/1894 ,  C10L3/107 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/8851 ,  G01N33/24 ,  G01N33/28 ,  G01N35/1095 ,  G01N2021/0346 ,  G01N2035/1034

摘要： A test method and test apparatus is provided that employs a microfluidic device to characterize properties of a fluid. The microfluidic device has a first inlet port, an outlet port, and a microchannel as part of a fluid path between the first inlet port and the outlet port. While generating a flow of the fluid through the microchannel of the microfluidic device, fluid pressure at the first inlet port of the microfluidic device is measured and recorded in conjunction with varying the controlled temperature of the microchannel of the microfluidic device to characterize the properties of the fluid that flows through the microchannel of the microfluidic device. The properties of the fluid can relate to the clathrate hydrate formation condition of the fluid at the pressure of the flow through the microchannel of the microfluidic device.

摘要翻译： 提供了一种使用微流体装置来表征流体性质的测试方法和测试装置。 微流体装置具有作为第一入口和出口之间的流体路径的一部分的第一入口端口，出口端口和微通道。 当通过微流体装置的微通道产生流体流时，测量并记录微流体装置的第一入口处的流体压力并结合改变微流体装置的微通道的受控温度进行记录，以表征微流体装置的特性 流过微流体装置的微通道的流体。 流体的性质可以涉及在通过微流体装置的微通道的流动的压力下的流体的笼形水合物形成条件。

公开(公告)号：US20150375209A1

公开(公告)日：2015-12-31

申请号：US14749441

申请日：2015-06-24

申请人： UNIVERSITY OF WYOMING

发明人： Maohong FAN ,  Tiberiu POPA

IPC分类号： B01J23/72 ,  B01J8/02 ,  B01J37/03 ,  B01J37/08 ,  C07C29/149 ,  B01J37/04

CPC分类号： B01J23/72 ,  B01J19/0093 ,  B01J29/064 ,  B01J29/14 ,  B01J29/46 ,  B01J35/023 ,  B01J37/035 ,  B01J37/036 ,  B01J37/08 ,  B01J2208/02 ,  B01J2219/00792 ,  B01J2219/00835 ,  B01J2219/00873 ,  B01J2219/00909 ,  B01J2219/00916 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00986 ,  B01J2523/00 ,  C07C29/149 ,  Y02P20/52 ,  C07C31/202 ,  B01J2523/17 ,  B01J2523/41

摘要： Embodiments described herein generally relate to hydrogenation catalysts, syntheses of hydrogenation catalysts, and apparatus and methods for hydrogenation. Methods for forming a hydrogenation catalyst may include mixing a silica generating precursor with a copper precursor and adding an ammonium salt to an end pH of between about 5 to about 9. Methods for hydrogenating an oxalate may include forming a reaction mixture by flowing a hydrogenation catalyst to a reactor, flowing a hydrogen source to the reactor, and flowing an oxalate to the reactor, wherein the hydrogenation catalyst has a particle size between about 10 nm to about 40 nm. Methods may further include reacting the oxalate to form ethylene glycol.

摘要翻译： 本文所述的实施方案通常涉及氢化催化剂，氢化催化剂的合成，以及用于氢化的装置和方法。 形成氢化催化剂的方法可以包括将二氧化硅生成前体与铜前体混合并加入铵盐至约5至约9的终止pH。用于氢化草酸盐的方法可包括通过使氢化催化剂 到一个反应器中，将氢源流到反应器中，并使草酸盐流到反应器中，其中氢化催化剂的粒度在约10nm到约40nm之间。 方法还可包括使草酸酯反应形成乙二醇。

公开(公告)号：US20140272045A1

公开(公告)日：2014-09-18

申请号：US14052514

申请日：2013-10-11

申请人： Advance International, Inc.

发明人： Shahmard Maziar Ghorbani ,  Kerry Coltun

IPC分类号： A23J1/04 ,  A23D9/02

CPC分类号： A23J1/04 ,  A23D9/02 ,  B01D3/00 ,  B01D11/0288 ,  B01D35/02 ,  B01D36/00 ,  B01J19/0053 ,  B01J19/18 ,  B01J2219/00909 ,  B01J2219/0095 ,  C11B1/10

摘要： The present invention describes a method and an automatic system for recovering protein powder meal, crude and pure omega-3 oil and purified distilled water from a mixture of animal tissue processed in a filter-drier-reaction tank. Animal tissue, for example fish, and organic solvent are directly or indirectly fed into the filter-drier-reaction tank. The filter-drier-reaction tank mixes, heats, and separates solid and heavy liquid portions of the mixture, the organic solvents are automatically recycled back in to the system after distillation. The solid portion is retained in the filter-drier-reaction tank and baked. Solid protein powder product (the protein powder meal) is thus recovered.

摘要翻译： 本发明描述了一种从过滤 - 干燥 - 反应槽中处理的动物组织的混合物中回收蛋白粉粉，粗和纯ω-3油和纯化蒸馏水的方法和自动系统。 动物组织，例如鱼和有机溶剂直接或间接地进料到过滤干燥反应罐中。 过滤干燥反应罐混合，加热并分离混合物的固体和重质液体部分，蒸馏后有机溶剂自动循环回系统。 将固体部分保留在过滤干燥反应罐中并烘烤。 固体蛋白粉产品（蛋白粉粉）因此被回收。

公开(公告)号：US20090311157A1

公开(公告)日：2009-12-17

申请号：US12519816

申请日：2007-12-20

申请人： Colin Steel ,  Robin Fortt ,  Elaine Liow ,  Stefan Riese

发明人： Colin Steel ,  Robin Fortt ,  Elaine Liow ,  Stefan Riese

IPC分类号： C01B7/20 ,  B01J4/00 ,  B01J19/00

CPC分类号： C07B59/00 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00909

摘要： A microscale solution for conducting [18F]fluoride phase transfer and subsequent radiosynthesis of 2-[18F]FDG that eliminates the azeotropic drying process. [18F]fluoride phase transfer is performed using an inexpensive disposable microchip. Additionally, each subsequent each step may be performed on the same single microchip.

摘要翻译： 用于进行[18 F]氟化物相转移和随后的2- [18 F] FDG放射合成的微量溶液，消除了共沸干燥过程。 [18F]使用廉价的一次性微芯片进行氟化物相转移。 此外，每个后续的每个步骤可以在相同的单个微芯片上执行。

公开(公告)号：US20090110602A1

公开(公告)日：2009-04-30

申请号：US12010329

申请日：2008-01-24

申请人： Chi-Yuan Lee ,  Shuo-Jen Lee ,  Chien-Heng Lin ,  Ren-De Huang ,  Wei-Jung Hsieh

发明人： Chi-Yuan Lee ,  Shuo-Jen Lee ,  Chien-Heng Lin ,  Ren-De Huang ,  Wei-Jung Hsieh

IPC分类号： G01N27/00

CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00835 ,  B01J2219/00853 ,  B01J2219/00909 ,  B01J2219/0095 ,  B01J2219/00959 ,  B01J2219/00961 ,  H01M8/04089 ,  H01M8/04186

摘要： A fluid reactor having a thin film with two-dimensionally distributed micro-resistor units includes one flow way, separating ribs, a thin film which is thinner than 100 micrometer, and a catalytic layer. There are multiple micro-resistor units, which is thinner than 60 micrometer each, set on the thin film. A bi-directional control unit is disposed to control these multiple micro-resistor units to shift to a desired mode selected from detecting electrical resistance, voltage, current, temperature, flow speed, and/or heat-up functions at different time. It can be applied to different kinds of fuel cells with different flow-way patterns. Its micro-resistor units have bi-directional functions. It can detect flow speed at a desired location in the flow way. It would not influence its original flow field and structure. Plus, it is easy to be installed.

摘要翻译： 具有二维分布的微电阻器单元的薄膜的流体反应器包括一个流动方式，分离肋，比100微米薄的薄膜和催化层。 有多个微电阻器单元，它们比薄膜都薄于60微米。 设置双向控制单元以控制这些多个微电阻器单元移动到在不同时间检测电阻，电压，电流，温度，流速和/或加热功能所选择的期望模式。 它可以应用于不同种类的具有不同流动方式的燃料电池。 其微电阻单元具有双向功能。 它可以以流量方式检测所需位置的流速。 它不会影响其原始流场和结构。 此外，它很容易安装。

公开(公告)号：US20080233018A1

公开(公告)日：2008-09-25

申请号：US12011220

申请日：2008-01-23

申请人： Robert Michael van Dam ,  Carroll Edward Ball ,  Arkadij M. Elizarov ,  Hartmuth C. Kolb

发明人： Robert Michael van Dam ,  Carroll Edward Ball ,  Arkadij M. Elizarov ,  Hartmuth C. Kolb

IPC分类号： B01J19/00 ,  C07H1/00

CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00907 ,  B01J2219/00909 ,  B01J2219/00952 ,  B01J2219/00959 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00986 ,  B01J2219/0099 ,  C07B59/005

摘要： The present application relates to microfluidic devices and related technologies, and to chemical processes using such devices. More specifically, the application discloses a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner. In particular, this application describe an automated, stand-alone, microfluidic instrument for the multi-step chemical synthesis of radiopharmaceuticals, such as probes for PET and a method of using such instruments.

摘要翻译： 本申请涉及微流体装置和相关技术，以及使用这种装置的化学过程。 更具体地，本申请公开了以快速，有效和紧凑的方式例如通过正电子发射断层摄影（PET）来成像的放射性化合物的全自动合成。 特别地，本申请描述了用于放射性药物的多步化学合成的自动化，独立的微流体仪器，例如用于PET的探针和使用这种仪器的方法。

公开(公告)号：US07364704B2

公开(公告)日：2008-04-29

申请号：US11493997

申请日：2006-07-27

申请人： Steven A. Sundberg ,  J. Wallace Parce ,  Calvin Y. H. Chow

发明人： Steven A. Sundberg ,  J. Wallace Parce ,  Calvin Y. H. Chow

IPC分类号： G01N1/10 ,  B01L3/02

CPC分类号： G01N27/44791 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44743 ,  G01N2035/00237 ,  G01N2035/1037 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

公开(公告)号：US20060234381A1

公开(公告)日：2006-10-19

申请号：US11425895

申请日：2006-06-22

申请人： Thomas Schwalbe ,  Volker Autze ,  Sebastian Oberbeck ,  Ansgar Kursawe ,  Kemal Sahin

发明人： Thomas Schwalbe ,  Volker Autze ,  Sebastian Oberbeck ,  Ansgar Kursawe ,  Kemal Sahin

IPC分类号： G01N31/10

CPC分类号： B01J19/0093 ,  B01J19/0033 ,  B01J2219/00166 ,  B01J2219/00186 ,  B01J2219/0059 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00867 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00909 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00977 ,  B01J2219/00984 ,  B01J2219/00986 ,  G05B13/024 ,  Y10T436/11 ,  Y10T436/12

摘要： A reaction system enables a plurality of optimization experiments for a reaction to be performed continuously, to enable optimal reaction parameters to be determined. Dilution pumps are included to automatically vary the solvent mixed with reactants so a concentration of each reactant can be selectively varied. The reactants are introduced into a reaction module selectively coupled to residence time chambers or directly to an analytical unit. The analytical unit determines the yield and/or quality for each optimization experiment, enabling optimal parameters to be determined. Residence time chambers can be employed sequentially to enable total residence time to be varied. The controller performs as many experiments as required to enable each parameter to be varied according to a predefined testing program and can redefine a testing program based on the results from previous experiments. At least two reaction parameters can be varied according to periodic functions to further enhance analytical efficiency.

摘要翻译： 反应系统能够进行连续执行反应的多个优化实验，以确定最佳反应参数。 包括稀释泵以自动改变与反应物混合的溶剂，从而可以选择性地改变每种反应物的浓度。 将反应物引入选择性地连接到停留时间室的反应模块中，或直接引入分析单元。 分析单元确定每个优化实验的产量和/或质量，从而确定最佳参数。 可以顺序使用停留时间室，以使总停留时间变化。 控制器根据需要执行尽可能多的实验，以使每个参数根据预定义的测试程序而变化，并可以基于先前实验的结果重新定义测试程序。 至少两个反应参数可以根据周期功能而变化，以进一步提高分析效率。