Invention Grant
US09221029B2 Automatic system for synthesizing 123I-MIBG and automatic device for synthesizing and dispensing 123I-MIBG comprising the same
有权
用于合成123I-MIBG的自动系统和用于合成和分配123I-MIBG的自动装置
- Patent Title: Automatic system for synthesizing 123I-MIBG and automatic device for synthesizing and dispensing 123I-MIBG comprising the same
- Patent Title (中): 用于合成123I-MIBG的自动系统和用于合成和分配123I-MIBG的自动装置
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Application No.: US14464461Application Date: 2014-08-20
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Publication No.: US09221029B2Publication Date: 2015-12-29
- Inventor: Tsai-Yueh Luo , Te-Sheng Liang , Ying-Hsia Shih , Wuu-Jyh Lin
- Applicant: Institute of Nuclear Energy Research Atomic Energy Council, Executive Yuan
- Applicant Address: TW Longtan Township, Taoyuan County
- Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN
- Current Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN
- Current Assignee Address: TW Longtan Township, Taoyuan County
- Agency: Muncy, Geissler, Olds & Lowe, P.C.
- Priority: TW102129819 20130820
- Main IPC: B01J19/24
- IPC: B01J19/24 ; B01J19/00 ; A61K51/04 ; C07B59/00
Abstract:
The present invention relates to an automatic system for synthesizing iodine-123 meta-iodobenzylguanidine (123I-MIBG), which comprises a first reactor for subjecting radioactive iodine-containing sodium iodide and meta-iodobenzylguanidine (MIBG) sulfate to an iodine-iodine exchange reaction to obtain radioactive iodine labeled MIBG; a purification unit for purifying the iodine labeled MIBG; and a second reactor for substituting a solvent used in purification with a phosphate buffer to obtain a phosphate solution containing 123I-MIBG. The present invention also relates to an automatic device for dispensing 123I-MIBG, which comprises the automatic system for synthesizing 123I-MIBG, a radioactivity measuring unit, and a dispensing and packing unit.
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