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公开(公告)号：US20240368211A1
公开(公告)日：2024-11-07
申请号：US18290604
申请日：2022-07-19
Inventor： Peter WUTS , William F. RENCHER , Tony ZHANG , Boyu ZHONG , Anjiang YANG , Fei LV , Qihua ZHAO , Jiaoyang FENG , Jifa WANG
Abstract: The present disclosure describes novel processes and intermediates for making onapristone.
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公开(公告)号：US11905309B2
公开(公告)日：2024-02-20
申请号：US17381829
申请日：2021-07-21
Applicant: Sage Therapeutics, Inc.
Inventor： Gabriel Martinez Botella , Boyd L Harrison , Albert Jean Robichaud , Francesco G. Salituro
CPC classification number: C07J9/00 , C07J9/005 , C07J13/005 , C07J13/007 , C07J21/008 , C07J41/0061
Abstract: 3beta, 17beta disubstituted steroidal compounds, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, are provided for the prevention and treatment of a variety of CNS-related conditions.
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公开(公告)号：US11498940B2
公开(公告)日：2022-11-15
申请号：US16843822
申请日：2020-04-08
Applicant: Sage Therapeutics, Inc.
Inventor： Gabriel Martinez Botella , Boyd L. Harrison , Albert Jean Robichaud , Francesco G. Salituro , Robert Jason Herr , Robert Borbo Kargbo
Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -------, R1, R2, R5, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
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公开(公告)号：US11149057B2
公开(公告)日：2021-10-19
申请号：US16924814
申请日：2020-07-09
Applicant: Sage Therapeutics, Inc.
Inventor： Boyd L. Harrison , Gabriel Martinez Botella , Albert Jean Robichaud , Francesco G. Salituro
Abstract: Described herein are steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein R1, R2a, R2b, R3, R4, R5a, R5b, R6 and Z are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
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公开(公告)号：US11046728B2
公开(公告)日：2021-06-29
申请号：US16393396
申请日：2019-04-24
Applicant: Sage Therapeutics, Inc.
Inventor： Gabriel Martinez Botella , Boyd L. Harrison , Albert Jean Robichaud , Francesco G. Salituro
IPC: C07J41/00 , A61K45/06 , A61K31/56 , A61K31/565 , A61K31/567 , C07J1/00 , C07J5/00 , C07J11/00 , C07J21/00 , C07J31/00 , C07J51/00 , C07J71/00
Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein R1a and R1b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
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Patent Agency Ranking
公开(公告)号：US10738075B2
公开(公告)日：2020-08-11
申请号：US16038735
申请日：2018-07-18
Applicant: Evestra, Inc.
Inventor： Hareesh Nair , Bindu Santhamma , Klaus Nickisch
Abstract: Described herein are new anti-cancer compounds and methods of using such compounds, acting through a new mechanism of action by simultaneous inhibition of leukemia inhibitory factor (LIF) and MDM2.
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公开(公告)号：US10723759B2
公开(公告)日：2020-07-28
申请号：US16562204
申请日：2019-09-05
Applicant: ORIC Pharmaceuticals, Inc.
Inventor： Daqing Sun , Lawrence R. McGee , Xiaohui Du , Liusheng Zhu , Xuelei Yan , Yosup Rew , John Eksterowicz , Julio C. Medina , Valeria R. Fantin , Haiying Zhou , Minna Delarae Balbas
Abstract: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
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8.发明申请公开(公告)号：US20190284227A1
公开(公告)日：2019-09-19
申请号：US16302059
申请日：2017-05-18
Applicant: NZP UK Limited
Inventor： Alexander Weymouth-Wilson , Zofia Komsta , Laura Wallis , Timothy Evans , Ieuan Davies , Carl Otter , Rhys Batchelor
Abstract: The invention relates to compounds of general formula (I): wherein: , R1, R2, R3, R4, R5, R6 and Y are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease.
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公开(公告)号：US10329320B2
公开(公告)日：2019-06-25
申请号：US15552201
申请日：2016-02-19
Applicant: Sage Therapeutics, Inc.
Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein R1, R2, Ra, G, X, Y, Z, and n are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a compound described herein and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
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公开(公告)号：US20190135821A1
公开(公告)日：2019-05-09
申请号：US16084117
申请日：2017-03-13
Inventor： Paul J. HERGENROTHER , Michelle Richter , Andrew Riley , Bryon Drown , Martin Chavez , Sarah Tasker , Alfredo Garcia
IPC: C07D491/052 , C07D413/12 , C07D413/10 , C07D413/04 , C07D413/14 , C07C225/20 , C07D417/12 , C07D263/20 , C07D407/06 , C07D407/12 , C07D471/04 , C07D471/14 , C07D471/20 , C07D498/04 , C07J13/00 , C07J41/00 , C07J43/00 , C07J1/00 , C07J21/00 , C07J73/00 , A61P31/04
Abstract: Disclosed are compounds that accumulate in Gram-negative bacteria. Also disclosed are method of antimicrobial treatment using the compounds.
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