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公开(公告)号：US10329320B2
公开(公告)日：2019-06-25
申请号：US15552201
申请日：2016-02-19
Applicant: Sage Therapeutics, Inc.
Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein R1, R2, Ra, G, X, Y, Z, and n are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a compound described herein and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
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公开(公告)号：US20180141971A1
公开(公告)日：2018-05-24
申请号：US15639702
申请日：2017-06-30
Applicant: Sage Therapeutics, Inc.
Inventor： Gabriel Martinez Botella , Boyd L. Harrison , Albert J. Robichaud , Francesco G. Salituro , Richard T. Beresis
IPC: C07J43/00 , C07J9/00 , C07J7/00 , C07J17/00 , C07J33/00 , C07J1/00 , C07J13/00 , C07J3/00 , C07J21/00 , C07J41/00
CPC classification number: A61K31/58 , A61K31/573 , C07J1/0059 , C07J1/007 , C07J1/0074 , C07J3/00 , C07J3/005 , C07J5/0015 , C07J7/00 , C07J7/002 , C07J7/007 , C07J7/008 , C07J7/0085 , C07J9/00 , C07J13/007 , C07J15/00 , C07J17/00 , C07J21/00 , C07J31/006 , C07J33/002 , C07J41/0066 , C07J43/003
Abstract: Provided herein are 19-nor C3,3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein , R1, R2, R3a, R3b, R4a, and R4b are as defined herein, and A is a carbon bound substituted or unsubstituted 5- to 6-membered heteroaryl ring as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
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公开(公告)号：US20170342103A1
公开(公告)日：2017-11-30
申请号：US15681983
申请日：2017-08-21
Applicant: Sage Therapeutics, Inc.
Inventor： Ravindra B. Upasani , Benny C. Askew , Boyd L. Harrison , Francesco G. Salituro , Albert J. Robichaud
CPC classification number: C07J43/003 , C07J5/0015 , C07J7/002 , C07J7/008 , C07J7/0085 , C07J9/005 , C07J31/006
Abstract: Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I) and (III): where R1, R2, R3, R3′, R4, R6a, R6a, R11a, and R11b are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, insomnia, anxiety, depression, traumatic brain injury (TBI), stress, and epilepsy.
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公开(公告)号：US10426837B2
公开(公告)日：2019-10-01
申请号：US15660114
申请日：2017-07-26
Applicant: Sage Therapeutics, Inc.
IPC: A61K45/06 , C07J43/00 , A61K31/00 , C07J3/00 , C07J7/00 , C07J13/00 , C07J41/00 , C07J51/00 , C07J9/00 , A61K45/00
Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein , A, R1, R2, and R3 are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use, e.g., for treating a subject suffering from a disease or disorder described herein.
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公开(公告)号：US20180237470A1
公开(公告)日：2018-08-23
申请号：US15917263
申请日：2018-03-09
Applicant: Sage Therapeutics, Inc.
CPC classification number: C07J9/00 , C07J9/005 , C07J13/005 , C07J13/007 , C07J21/008 , C07J41/0061
Abstract: Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3a, R3b, R4, R5a, R5b, R6a, and R6b are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of CNS-related conditions.
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Patent Agency Ranking
公开(公告)号：US20170319695A1
公开(公告)日：2017-11-09
申请号：US15660114
申请日：2017-07-26
Applicant: Sage Therapeutics, Inc.
IPC: A61K45/06 , C07J43/00 , C07J41/00 , C07J13/00 , C07J7/00 , C07J3/00 , C07J51/00 , A61K31/00 , A61K45/00
CPC classification number: A61K45/06 , A61K31/00 , A61K45/00 , C07J3/00 , C07J3/005 , C07J7/002 , C07J7/007 , C07J7/0085 , C07J7/009 , C07J9/00 , C07J13/007 , C07J41/0044 , C07J43/003 , C07J51/00
Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein , A, R1, R2, and R3 are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use, e.g., for treating a subject suffering from a disease or disorder described herein.
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公开(公告)号：US20170233433A1
公开(公告)日：2017-08-17
申请号：US15519478
申请日：2015-10-16
Applicant: Sage Therapeutics, Inc.
CPC classification number: C07J43/003 , A61K9/0019 , A61K9/0053 , A61K31/58 , A61P25/00 , C07D231/14 , C07D249/04 , C07D249/18 , C07D295/033
Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein, R1, R2a, R2b, R3 and A are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
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公开(公告)号：US20160031930A1
公开(公告)日：2016-02-04
申请号：US14775678
申请日：2014-03-13
Applicant: SAGE THERAPEUTICS, INC.
IPC: C07J9/00
CPC classification number: C07J9/00 , C07J9/005 , C07J13/005 , C07J13/007 , C07J21/008 , C07J41/0061
Abstract: (3alpha,3beta)-disubstituted 17beta steroidal compounds, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, are provided for the prevention and treatment of a variety of CNS-related conditions.
Abstract translation: （3α，3β） - 二取代的17β甾体化合物及其药学上可接受的盐及其药物组合物，用于预防和治疗各种CNS相关病症。
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9.发明申请3,3 DISUBSTITUTED 19-NOR PREGNANE COMPOUNDS, COMPOSITIONS, AND USES THEREOF 审中-公开3,3分散的19-NOR非离子表面活性剂，组合物及其用途公开(公告)号：US20150291654A1
公开(公告)日：2015-10-15
申请号：US14351449
申请日：2012-10-12
Applicant: SAGE THERAPEUTICS, INC.
Inventor： Ravindra B. Upasani , Benny C. Askew, Jr. , Boyd L. Harrison , Peter Scott DiStefano , Francesco G. Salituro , Albert J. Robichaud
CPC classification number: C07J43/003 , C07J5/0015 , C07J7/002 , C07J7/008 , C07J7/0085 , C07J9/005 , C07J31/006
Abstract: Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I) and (III): where R1, R2, R3, R3′, R4, R6a, R6a, R11a, and R11b are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, insomnia, anxiety, depression, traumatic brain injury (TBI), stress, and epilepsy.
Abstract translation: 本文提供根据式（I）和（III）的3,3-二取代的19-去甲甾族化合物：其中R1，R2，R3，R3'，R4，R6a，R6a，R11a和R11b如本文所定义。 本发明的化合物可用于预防和治疗各种CNS相关病症，例如睡眠障碍，情绪障碍，失眠，焦虑，抑郁，创伤性脑损伤（TBI），压力和癫痫的治疗 。
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公开(公告)号：US10323059B2
公开(公告)日：2019-06-18
申请号：US15698151
申请日：2017-09-07
Applicant: Sage Therapeutics, Inc.
IPC: C07J41/00 , A61K45/06 , A61K31/56 , A61K31/565 , A61K31/567 , C07J1/00 , C07J5/00 , C07J11/00 , C07J21/00 , C07J31/00 , C07J51/00 , C07J71/00
Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein R1a and R1b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
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