Invention Application
US20150291654A1 3,3 DISUBSTITUTED 19-NOR PREGNANE COMPOUNDS, COMPOSITIONS, AND USES THEREOF
审中-公开
3,3分散的19-NOR非离子表面活性剂，组合物及其用途
- Patent Title: 3,3 DISUBSTITUTED 19-NOR PREGNANE COMPOUNDS, COMPOSITIONS, AND USES THEREOF
- Patent Title (中): 3,3分散的19-NOR非离子表面活性剂，组合物及其用途
-
Application No.: US14351449Application Date: 2012-10-12
-
Publication No.: US20150291654A1Publication Date: 2015-10-15
- Inventor: Ravindra B. Upasani , Benny C. Askew, Jr. , Boyd L. Harrison , Peter Scott DiStefano , Francesco G. Salituro , Albert J. Robichaud
- Applicant: SAGE THERAPEUTICS, INC.
- Applicant Address: US MA Cambridge
- Assignee: SAGE THERAPEUTICS, INC.
- Current Assignee: SAGE THERAPEUTICS, INC.
- Current Assignee Address: US MA Cambridge
- International Application: PCT/US2012/060136 WO 20121012
- Main IPC: C07J43/00
- IPC: C07J43/00 ; C07J9/00 ; C07J5/00 ; C07J7/00
Abstract:
Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I) and (III): where R1, R2, R3, R3′, R4, R6a, R6a, R11a, and R11b are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, insomnia, anxiety, depression, traumatic brain injury (TBI), stress, and epilepsy.
Information query
