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公开(公告)号：US20180099257A1
公开(公告)日：2018-04-12
申请号：US15728986
申请日：2017-10-10
Inventor： James Gary Eden , Sung-Jin Park , Charles Shin , Andrey Mironov
CPC classification number: B01J19/0093 , B01J2219/00783 , B01J2219/00853 , B01J2219/0086 , B01J2219/0093 , B01J2219/00936 , B01J2219/0095 , B01J2219/0801 , B01J2219/0807 , B01J2219/083 , B01J2219/0835 , B01J2219/0841 , B01J2219/0843 , B01J2219/0894 , B01J2219/2402 , B01J2219/2419 , C01B13/115 , C01B2201/22 , C01B2201/82
Abstract: A method for generating a hybrid reaction flows feedstock gas that is also a plasma medium through microchannels. Plasma is generated with the plasma medium via excitation with a time-varying voltage. UV or VUV emissions are generated at a wavelength selected to break a chemical bond in the feedstock gas. The UV or VUV emissions are directed into the microchannels to interact with the plasma medium and generate a reaction product from the plasma medium. A hybrid reactor device includes a microchannel plasma array having inlets and outlets for respectively flowing gas feedstock into and reaction product out of the microchannel plasma array. A UV or VUV emission lamp has its emissions directed into microchannels of the microchannel plasma array. Electrodes ignite plasma in the microchannels and stimulating the UV or VUV emission lamp to generate UV or VUV emissions. One common or plural phased time-varying voltage sources drive the plasma array and the UV or VUV emission lamp.
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公开(公告)号：US09259735B2
公开(公告)日：2016-02-16
申请号：US14317356
申请日：2014-06-27
Applicant: HandyLab, Inc.
Inventor： Kalyan Handique , Karthik Ganesan , Sundaresh N. Brahmasandra
CPC classification number: B01L7/52 , B01F13/0071 , B01F13/0079 , B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00837 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00936 , B01J2219/00943 , B01J2219/00945 , B01J2219/00961 , B01J2219/0097 , B01J2219/00986 , B01L3/502784 , B01L3/502792 , B01L2200/0605 , B01L2200/0673 , B01L2200/14 , B01L2300/0816 , B01L2400/0442 , B01L2400/0493 , B01L2400/0677 , G01N1/4077 , G01N35/1083 , Y10T436/12 , Y10T436/25 , Y10T436/2575
Abstract: The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined configurations. Such microfluidic devices are preferably constructed in a hierarchical and modular fashion which is reflected in the preferred structure of the provided methods and systems. In particular, the methods are structured into low-level device component control functions, middle-level actuator control functions, and high-level micro-droplet control functions. Advantageously, a microfluidic device may thereby be instructed to perform an intended reaction or analysis by invoking micro-droplet control function that perform intuitive tasks like measuring, mixing, heating, and so forth. The systems are preferably programmable and capable of accommodating microfluidic devices controlled by low voltages and constructed in standardized configurations. Advantageously, a single control system can thereby control numerous different reactions in numerous different microfluidic devices simply by loading different easily understood micro-droplet programs.
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公开(公告)号：US20140377850A1
公开(公告)日：2014-12-25
申请号：US14317356
申请日：2014-06-27
Applicant: HandyLab, Inc.
Inventor： Kalyan Handique , Karthik Ganesan , Sundaresh N. Brahmasandra
CPC classification number: B01L7/52 , B01F13/0071 , B01F13/0079 , B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00837 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00936 , B01J2219/00943 , B01J2219/00945 , B01J2219/00961 , B01J2219/0097 , B01J2219/00986 , B01L3/502784 , B01L3/502792 , B01L2200/0605 , B01L2200/0673 , B01L2200/14 , B01L2300/0816 , B01L2400/0442 , B01L2400/0493 , B01L2400/0677 , G01N1/4077 , G01N35/1083 , Y10T436/12 , Y10T436/25 , Y10T436/2575
Abstract: The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined configurations. Such microfluidic devices are preferably constructed in a hierarchical and modular fashion which is reflected in the preferred structure of the provided methods and systems. In particular, the methods are structured into low-level device component control functions, middle-level actuator control functions, and high-level micro-droplet control functions. Advantageously, a microfluidic device may thereby be instructed to perform an intended reaction or analysis by invoking micro-droplet control function that perform intuitive tasks like measuring, mixing, heating, and so forth. The systems are preferably programmable and capable of accommodating microfluidic devices controlled by low voltages and constructed in standardized configurations. Advantageously, a single control system can thereby control numerous different reactions in numerous different microfluidic devices simply by loading different easily understood micro-droplet programs.
Abstract translation: 本发明提供了通过一系列确定的配置移动离散微滴来操作的微流体装置的控制方法，控制系统和控制软件。 这种微流体装置优选地以分级和模块化的方式构成，其反映在所提供的方法和系统的优选结构中。 特别地，这些方法被构造成低级器件部件控制功能，中间级执行器控制功能和高级微滴控制功能。 有利地，可以通过调用执行直观任务（如测量，混合，加热等）的微滴控制功能来指示微流体装置来执行预期的反应或分析。 该系统优选地是可编程的并且能够容纳由低电压控制并以标准化配置构造的微流体装置。 有利地，单个控制系统因此可以通过加载不同的容易理解的微液滴程序来控制许多不同微流体装置中的许多不同反应。
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4.发明授权Chemical synthesis and analysis via integrated, sequential and series-parallel photochemical and other chemical processes for microfluidic, lab-on-a-chip, and green-chemistry applications 有权用于微流体，芯片实验室和绿色化学应用的综合，顺序和串联并行光化学和其他化学过程的化学合成和分析公开(公告)号：US08877143B2
公开(公告)日：2014-11-04
申请号：US14287181
申请日：2014-05-26
Applicant: Lester Ludwig
Inventor： Lester Ludwig
CPC classification number: B01L3/502715 , B01J19/0093 , B01J2219/00835 , B01J2219/00853 , B01J2219/00867 , B01J2219/00869 , B01J2219/00936 , B01J2219/00959 , B01J2219/00961 , B01J2219/00963 , B01J2219/00966 , B01J2219/0097 , B01J2219/00986 , Y10T436/11 , Y10T436/25 , Y10T436/2575
Abstract: A microfluidic system comprising a plurality of photochemical reaction stages, the microfluidic system comprising a computational processor, a plurality of electrically-controllable photochemical reaction stages, and a series of controllable interconnections for connecting the photochemical reaction stages. In an implementation, the computational processor controls the electrically-controllable photochemical and other chemical reaction stages together with controllable interconnections so as to implement multi-step chemical processes. The microfluidic system can be configured to selectively drive a plurality of photochemical reactions within a mixture of chemical compounds via controlled emission of light of a plurality of wavelengths. The microfluidic system can be configured to comprise various interconnections and combinations of parallel and series chemical reaction stages, and can include a multichannel microfluidic chemical transfer bus. The microfluidic system can be configured to handle and process liquid, gasses, solids, and mixtures of these, and can used to implement anion relay chemistry, combinational chemistry, and synthon-based synthesis.
Abstract translation: 一种包含多个光化学反应阶段的微流体系统，所述微流体系统包括计算处理器，多个电可控光化学反应级和用于连接光化学反应级的一系列可控互连。 在一个实施方案中，计算处理器控制电可控的光化学和其它化学反应级以及可控互连，以便实现多步化学过程。 微流体系统可以被配置为通过受控发射多个波长的光来选择性地驱动化学化合物的混合物内的多个光化学反应。 微流体系统可以被配置为包括并联和串联化学反应级的各种互连和组合，并且可以包括多通道微流控化学传递总线。 微流体系统可以被配置为处理和处理液体，气体，固体和它们的混合物，并且可以用于实现阴离子中继化学，组合化学和基于合成子的合成。
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5.发明授权Method of producing polymeric particles with selected size, shape, morphology and composition 有权制备具有选定尺寸，形状，形态和组成的聚合物颗粒的方法公开(公告)号：US08696952B2
公开(公告)日：2014-04-15
申请号：US11587251
申请日：2005-04-25
Applicant: Eugenia Kumacheva , Shengqing Xu , Zhihong Nie , Min Seok Seo , Patrick Cameron Lewis , Hong Zhang
Inventor： Eugenia Kumacheva , Shengqing Xu , Zhihong Nie , Min Seok Seo , Patrick Cameron Lewis , Hong Zhang
CPC classification number: C08J3/16 , A61K9/1641 , A61K9/1694 , A61K9/5031 , A61K9/5036 , B01F3/0807 , B01F5/0647 , B01F13/0062 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00936 , B01J2219/00984 , B82Y10/00 , B82Y30/00 , Y10T436/2575
Abstract: The present invention provides a method and apparatus for producing polymeric particles with pre-designed size, shape, morphology and composition, and more particularly the present invention uses a microfluidic polymerization reactor for producing same. The present invention disclosed herein provides a process for producing polymer particles with pre-selected shapes. The method includes injecting a first fluid comprising a polymerizable constituent with a controlled flow rate into a microfluidic channel and injecting a second fluid with a controlled flow rate into the microfluidic channel in which the second fluid mixes with the first fluid, the second fluid being immiscible with the first fluid so that the first fluid forms into droplets in the microfluidic channel. The microfluidic channel has pre-selected dimensions to give droplets of pre-selected size, morphology and shape. The microfluidic channel is sufficiently long so that the droplets have a sufficiently long residence time in the channel so that they polymerize or otherwise harden into droplets of pre-selected size and shape.
Abstract translation: 本发明提供了一种用于制备具有预先设计的尺寸，形状，形态和组成的聚合物颗粒的方法和装置，更具体地，本发明使用微流体聚合反应器来生产聚合物颗粒。 本文公开的本发明提供了一种用于制备具有预选形状的聚合物颗粒的方法。 该方法包括将包含可控流速的可聚合组分的第一流体注入微流体通道并将具有受控流速的第二流体注射到第二流体与第一流体混合的微流体通道中，第二流体是不混溶的 第一流体使得第一流体在微流体通道中形成液滴。 微流体通道具有预选的尺寸以产生预选尺寸，形态和形状的液滴。 微流体通道足够长，使得液滴在通道中具有足够长的停留时间，使得它们聚合或以其它方式硬化成预选尺寸和形状的液滴。
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Patent Agency Ranking
公开(公告)号：US20130280131A1
公开(公告)日：2013-10-24
申请号：US13925046
申请日：2013-06-24
Applicant: Handylab, Inc.
Inventor： KALYAN HANDIQUE , KARTHIK GANESAN , SUNDARESH N. BRAHMASANDRA
IPC: G01N35/10
CPC classification number: B01L7/52 , B01F13/0071 , B01F13/0079 , B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00837 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00936 , B01J2219/00943 , B01J2219/00945 , B01J2219/00961 , B01J2219/0097 , B01J2219/00986 , B01L3/502784 , B01L3/502792 , B01L2200/0605 , B01L2200/0673 , B01L2200/14 , B01L2300/0816 , B01L2400/0442 , B01L2400/0493 , B01L2400/0677 , G01N1/4077 , G01N35/1083 , Y10T436/12 , Y10T436/25 , Y10T436/2575
Abstract: The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined configurations. Such microfluidic devices are preferably constructed in a hierarchical and modular fashion which is reflected in the preferred structure of the provided methods and systems. In particular, the methods are structured into low-level device component control functions, middle-level actuator control functions, and high-level micro-droplet control functions. Advantageously, a microfluidic device may thereby be instructed to perform an intended reaction or analysis by invoking micro-droplet control function that perform intuitive tasks like measuring, mixing, heating, and so forth. The systems are preferably programmable and capable of accommodating microfluidic devices controlled by low voltages and constructed in standardized configurations. Advantageously, a single control system can thereby control numerous different reactions in numerous different microfluidic devices simply by loading different easily understood micro-droplet programs.
Abstract translation: 本发明提供了通过一系列确定的配置移动离散微滴来操作的微流体装置的控制方法，控制系统和控制软件。 这种微流体装置优选地以分级和模块化的方式构成，其反映在所提供的方法和系统的优选结构中。 特别地，这些方法被构造成低级器件部件控制功能，中间级执行器控制功能和高级微滴控制功能。 有利地，可以通过调用执行直观任务（如测量，混合，加热等）的微滴控制功能来指示微流体装置来执行预期的反应或分析。 该系统优选地是可编程的并且能够容纳由低电压控制并以标准化配置构造的微流体装置。 有利地，单个控制系统因此可以通过加载不同的容易理解的微液滴程序来控制许多不同微流体装置中的许多不同反应。
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7.发明授权Multiple continuous microfluidic reactors for the scaled up synthesis of gel or polymer particles 有权用于大规模合成凝胶或聚合物颗粒的多个连续微流控反应器公开(公告)号：US08476382B2
公开(公告)日：2013-07-02
申请号：US12451886
申请日：2008-06-05
Applicant: Eugenia Kumacheva
Inventor： Eugenia Kumacheva
CPC classification number: B01F13/0062 , B01F3/0807 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00869 , B01J2219/00873 , B01J2219/00889 , B01J2219/0093 , B01J2219/00934 , B01J2219/00936 , Y10T137/2076 , Y10T137/2224
Abstract: This present invention provides devices for the parallelization of the formation of droplets in a multiple droplet generator integrating two or more parallel flow-focusing devices (FFDs) with either identical, or different, geometries. In the parallel identical FFDs, emulsification generates droplets with a narrow (below 4%) polydispersity despite weak coupling between the identical flow-focusing devices. Formation of droplets in the integrated droplet generator comprising FFDs with different dimensions of the microchannels occurs with strong coupling between the FFDs and produces droplets with varying sizes and size distributions. For such devices the regime in which emulsification produces droplets with varying dimensions and a narrow size distribution have been identified. The results of this work can be used in scaling up the production of droplets and in the simultaneous production of droplets and particles with different dimensions.
Abstract translation: 本发明提供了用于在集成两个或更多个具有相同或不同几何形状的平行流动聚焦装置（FFD）的多液滴发生器中并联形成液滴的装置。 在平行相同的FFD中，尽管相同的流动聚焦装置之间的弱耦合，乳化产生具有窄（低于4％）多分散性的液滴。 在包含具有不同尺寸的微通道的FFD的集成液滴发生器中的液滴的形成发生在FFD之间的强耦合并产生具有不同尺寸和尺寸分布的液滴。 对于这样的装置，已经确定乳化产生具有不同尺寸和窄尺寸分布的液滴的状态。 这项工作的结果可用于扩大液滴的产量和同时生产不同尺寸的液滴和颗粒。
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8.发明授权公开(公告)号：US08475738B2
公开(公告)日：2013-07-02
申请号：US13100890
申请日：2011-05-04
Applicant: Jongcheol Hong , Wan Joong Kim , Chul Huh , Bong Kyu Kim , Chil Seong Ah , Gun Yong Sung
Inventor： Jongcheol Hong , Wan Joong Kim , Chul Huh , Bong Kyu Kim , Chil Seong Ah , Gun Yong Sung
CPC classification number: B01L3/50273 , B01J19/0093 , B01J2219/00835 , B01J2219/00936 , B01L2200/0605 , B01L2400/046 , C01B13/0214
Abstract: Provided is a microfluidic injection device and a method for injecting microfluidic. The microfluidic injection device includes a fluid injection chamber, a gas generation chamber applying pressure to the fluid injection chamber, and a channel connecting the fluid injection chamber to the gas generation chamber.
Abstract translation: 提供了微流体注射装置和用于注射微流体的方法。 微流体注射装置包括流体注射室，向流体注射室施加压力的气体产生室以及将流体注入室连接到气体生成室的通道。
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9.发明授权Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure 有权具有多运行能力的放射合成模块化系统，降低辐射风险公开(公告)号：US08435454B2
公开(公告)日：2013-05-07
申请号：US12986323
申请日：2011-01-07
Applicant: Arkadij M. Elizarov , Carroll Edward Ball , Jianzhong Zhang , Hartmuth C. Kolb , Reza Miraghaie , Todd L. Graves , Artem Lebedev , Keith E. Schleiffer
Inventor： Arkadij M. Elizarov , Carroll Edward Ball , Jianzhong Zhang , Hartmuth C. Kolb , Reza Miraghaie , Todd L. Graves , Artem Lebedev , Keith E. Schleiffer
CPC classification number: B01J19/0093 , B01J2219/0081 , B01J2219/00826 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00871 , B01J2219/00873 , B01J2219/00889 , B01J2219/00905 , B01J2219/00936
Abstract: Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.
Abstract translation: 宏观和微流体装置及相关技术以及使用这种装置的化学过程。 更具体地，这些装置可以用于以有效，紧凑和安全的操作者方式全面自动化合成用于成像的放射性化合物，例如通过正电子发射断层摄影（PET）。 特别地，本发明的实施例涉及一种用于多步合成放射性药物的自动化，多运行微流控仪器，例如PET探针，其包括含有辐射递送部件的远程屏蔽微型电池。
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10.发明授权Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure 有权具有多运行能力的放射合成模块化系统，降低辐射风险公开(公告)号：US08273300B2
公开(公告)日：2012-09-25
申请号：US12803862
申请日：2010-07-08
Applicant: Arkadij M. Elizarov , Carroll Edward Ball , Jianzhong Zhang , Hartmuth C. Kolb , Reza Miraghaie , Todd Graves , Artem Lebedev
Inventor： Arkadij M. Elizarov , Carroll Edward Ball , Jianzhong Zhang , Hartmuth C. Kolb , Reza Miraghaie , Todd Graves , Artem Lebedev
CPC classification number: B01J19/0093 , B01J2219/0081 , B01J2219/00826 , B01J2219/0086 , B01J2219/00871 , B01J2219/00936
Abstract: Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.
Abstract translation: 宏观和微流体装置及相关技术以及使用这种装置的化学过程。 更具体地，这些装置可以用于以有效，紧凑和安全的操作者方式全面自动化合成用于成像的放射性化合物，例如通过正电子发射断层摄影（PET）。 特别地，本发明的实施例涉及一种用于多步合成放射性药物的自动化多运行微流体仪器，例如PET探针，其包括含有辐射递送部件的远程屏蔽微型电池。
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