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    MICROFLUIDIC, ELECTROCHEMICAL DEVICES
    3.
    发明申请
    MICROFLUIDIC, ELECTROCHEMICAL DEVICES 有权
    微电子，电化学设备

    公开(公告)号：US20120181184A1

    公开(公告)日：2012-07-19

    申请号：US13254967

    申请日：2010-03-08

    申请人： George M. Whitesides ,  Zhihong Nie ,  Christian Nijhuis ,  Xin Chen ,  Andres W. Martinez ,  Max Narovlyansky

    发明人： George M. Whitesides ,  Zhihong Nie ,  Christian Nijhuis ,  Xin Chen ,  Andres W. Martinez ,  Max Narovlyansky

    IPC分类号： G01N27/26 ,  G01N27/416

    CPC分类号： B01L3/5027 ,  B01L3/502 ,  B01L2300/0645 ,  B01L2300/0887 ,  G01N27/3272

    摘要： Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.

    摘要翻译： 描述了微流体，电化学装置。 微流体电化学装置包括在基底上的一个或多个电极和图案化的多孔亲水层，其具有基本上渗透多孔亲水层的厚度的流体不可渗透屏障，并限定一个或多个亲水性通道的边界 所述图案化的多孔亲水层，其中所述亲水沟道包括与所述电极流体连通的亲水区域。 在一些实施例中，电极包括工作电极，对电极和参考电极。 在一些实施例中，微流体，电化学装置还包括流体槽。 描述了组装微流体，电化学装置的方法。 还描述了使用该装置进行一种或多种分析物的电化学分析的方法。

    Systems and methods of forming particles
    5.
    发明申请
    Systems and methods of forming particles 审中-公开
    形成颗粒的系统和方法

    公开(公告)号：US20070054119A1

    公开(公告)日：2007-03-08

    申请号：US11368263

    申请日：2006-03-03

    申请人： Piotr Garstecki ,  Douglas Weibel ,  Irina Gitlin ,  Shoji Takeuchi ,  Shengqing Xu ,  Zhihong Nie ,  Min Seo ,  Patrick Lewis ,  Eugenia Kumacheva ,  Howard Stone ,  George Whitesides

    发明人： Piotr Garstecki ,  Douglas Weibel ,  Irina Gitlin ,  Shoji Takeuchi ,  Shengqing Xu ,  Zhihong Nie ,  Min Seo ,  Patrick Lewis ,  Eugenia Kumacheva ,  Howard Stone ,  George Whitesides

    IPC分类号： B32B1/00

    CPC分类号： B01J19/0093 ,  B01F3/0807 ,  B01F13/0062 ,  B01J19/06 ,  B01J2219/00873 ,  B22F1/0007 ,  B22F9/06 ,  Y10T428/2982

    摘要： The present invention generally relates to systems and methods of forming particles and, in certain aspects, to systems and methods of forming particles that are substantially monodisperse. Microfluidic systems and techniques for forming such particles are provided, for instance, particles may be formed using gellation, solidification, and/or chemical reactions such as cross-linking, polymerization, and/or interfacial polymerization reactions. In one aspect, the present invention is directed to a plurality of particles having an average dimension of less than about 500 micrometers and a distribution of dimensions such that no more than about 5% of the particles have a dimension greater than about 10% of the average dimension, which can be made via microfluidic systems. In one set of embodiments, at least some of the particles may comprise a metal, and in certain embodiments, at least some of the particles may comprise a magnetizable material. In another set of embodiments, at least some of the particles may be porous. In some embodiments, the invention includes non-spherical particles. Non-spherical particles may be formed, for example, by urging a fluidic droplet into a channel having a smallest dimension that is smaller than the diameter of a perfect mathematical sphere having a volume of the droplet, and solidifying the droplet, and/or by exposing at least a portion of a plurality of particles to an agent able to remove at least a portion of the particles.

    摘要翻译： 本发明一般涉及形成颗粒的系统和方法，并且在某些方面涉及形成基本上单分散的颗粒的体系和方法。 提供了用于形成这种颗粒的微流体系统和技术，例如，可以使用凝胶化，固化和/或化学反应如交联，聚合和/或界面聚合反应形成颗粒。 在一个方面，本发明涉及平均尺寸小于约500微米的多个颗粒和尺寸分布，使得不超过约5％的颗粒具有大于所述颗粒的约10％的尺寸 平均尺寸，可以通过微流体系统进行。 在一组实施方案中，至少一些颗粒可以包含金属，并且在某些实施方案中，至少一些颗粒可以包含可磁化材料。 在另一组实施方案中，至少一些颗粒可以是多孔的。 在一些实施方案中，本发明包括非球形颗粒。 非球形颗粒可以例如通过将流体液滴推入具有小于具有液滴体积的完美数学球体的直径的最小尺寸的通道，和/或通过 将多个颗粒的至少一部分暴露于能除去至少一部分颗粒的试剂。

    Microfluidic, electrochemical devices
    7.
    发明授权
    Microfluidic, electrochemical devices 有权
    微流控，电化学装置

    公开(公告)号：US09192933B2

    公开(公告)日：2015-11-24

    申请号：US13254967

    申请日：2010-03-08

    申请人： George M. Whitesides ,  Zhihong Nie ,  Christian Nijhuis ,  Xin Chen ,  Andres W. Martinez ,  Max Narovlyansky

    发明人： George M. Whitesides ,  Zhihong Nie ,  Christian Nijhuis ,  Xin Chen ,  Andres W. Martinez ,  Max Narovlyansky

    IPC分类号： G01N27/26 ,  B01L3/00 ,  G01N27/327

    CPC分类号： B01L3/5027 ,  B01L3/502 ,  B01L2300/0645 ,  B01L2300/0887 ,  G01N27/3272

    摘要： Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.

    摘要翻译： 描述了微流体，电化学装置。 微流体电化学装置包括在基底上的一个或多个电极和图案化的多孔亲水层，其具有基本上渗透多孔亲水层的厚度的流体不可渗透屏障，并限定一个或多个亲水性通道的边界 所述图案化的多孔亲水层，其中所述亲水沟道包括与所述电极流体连通的亲水区域。 在一些实施例中，电极包括工作电极，对电极和参考电极。 在一些实施例中，微流体，电化学装置还包括流体槽。 描述了组装微流体，电化学装置的方法。 还描述了使用该装置进行一种或多种分析物的电化学分析的方法。