公开(公告)号：US20240076656A1

公开(公告)日：2024-03-07

申请号：US18215296

申请日：2023-06-28

Applicant: 10x Genomics, Inc.

Inventor： David Michael PATTERSON ,  Steven William SHORT ,  Dieter WILK ,  Pingwei ZHUANG ,  Solongo Batjargal ZIRALDO

IPC: C12N15/10 ,  B01J19/00 ,  B41M5/24 ,  C12N9/12 ,  C12N9/22 ,  G03F7/11

CPC classification number: C12N15/1093 ,  B01J19/0046 ,  B41M5/24 ,  C12N9/1264 ,  C12N9/22 ,  C12Y207/07031 ,  C12Y301/11001 ,  G03F7/11 ,  B01J2219/00855 ,  B01J2219/00927 ,  B01J2219/00993 ,  B01J2219/0894 ,  B01J2540/68

Abstract: Provided in some aspects are methods for light-controlled in situ surface patterning of a substrate comprising a step of blocking or ablating oligonucleotide molecules in a boundary region separating a plurality of spot regions, and attaching oligonucleotides to oligonucleotide molecules in a first one or more of the spot regions.

公开(公告)号：US20180038513A1

公开(公告)日：2018-02-08

申请号：US15555120

申请日：2016-03-02

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Michael Baldea ,  Richard Pattison ,  Melissa Donahue ,  Akash Gupta

IPC: F16K99/00 ,  B01J19/00 ,  G05D23/185

CPC classification number: F16K99/0036 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00792 ,  B01J2219/00822 ,  B01J2219/00835 ,  B01J2219/00855 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00876 ,  B01J2219/0095 ,  F16K31/002 ,  F16K99/0026 ,  G05D23/1854

Abstract: Various implementations provide an inherently safer design feature for microchannel reactors that provides temperature control at the individual channel level. This approach relies on bimetallic strips embedded within the combustion channel, forming a thermally-actuated “valve”. Bimetallic strips convert a temperature change into a mechanical displacement. Heating the strip increases its deflection and thereby restricts flow in the combustion channels, which consequently reduces the rate of heat generation. The thermally-actuated valve is not limited to use in microchannel reactors and may be used in other structures for which thermally actuated flow control is desired, according to some implementations.

公开(公告)号：US20170113938A1

公开(公告)日：2017-04-27

申请号：US15310725

申请日：2015-05-13

Applicant: LG CHEM, LTD.

Inventor： Yoo Seok KIM ,  Jeong Kyu KIM ,  JinHyoung YOO ,  JungWoo LEE ,  Eunsu JANG

IPC: C01B33/107 ,  B01J19/24 ,  B01J10/00

CPC classification number: C01B33/10763 ,  B01J8/008 ,  B01J8/085 ,  B01J10/00 ,  B01J19/0093 ,  B01J19/2415 ,  B01J2208/00176 ,  B01J2208/0053 ,  B01J2208/00787 ,  B01J2219/00792 ,  B01J2219/00822 ,  B01J2219/00855 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/182 ,  C01B33/1071 ,  C01B33/10736

Abstract: The present invention relates to an apparatus for producing trichlorosilane from tetrachlorosilane in an efficient manner. The apparatus includes an inlet through which reaction raw materials including a metal silicon powder dispersed in liquid tetrachlorosilane enter, a hole through which a gaseous reaction raw material is fed, an outlet through which reaction products including trichlorosilane exit, a tubular reactor in which the reaction raw materials entering through the inlet react with each other during flow, and means for impeding the flow of the fluids to cause collision of the fluids during flow.

公开(公告)号：US20110147665A1

公开(公告)日：2011-06-23

申请号：US12642766

申请日：2009-12-18

Applicant: Paul W. Neagle ,  Anna Lee Tonkovich ,  Soumitra Deshmukh ,  Ravi Arora

Inventor： Paul W. Neagle ,  Anna Lee Tonkovich ,  Soumitra Deshmukh ,  Ravi Arora

IPC: C01B3/38 ,  B01J19/00

CPC classification number: B01J19/0093 ,  B01F5/061 ,  B01F13/0059 ,  B01F2005/0636 ,  B01J2219/00783 ,  B01J2219/00786 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/00855 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00997 ,  C01B3/384 ,  C01B2203/0233 ,  C01B2203/0283 ,  C01B2203/1064 ,  F28F7/02 ,  F28F2260/02

Abstract: Novel designs for microchannel apparatus are described in which microchannels are shaped to reduce the amount of material needed to build an apparatus. In these designs, some microchannels are shaped, in cross-section, to provide relatively more structural material in areas of greatest stress, while leaving greater area for unit operations in areas of the apparatus that are subjected to relatively less stress.

Abstract translation: 描述了用于微通道装置的新颖设计，其中微通道成形为减少构建装置所需的材料的量。 在这些设计中，一些微通道成形为横截面，以在应力最大的区域提供相对更多的结构材料，同时在经受相对较小应力的设备的区域中为单元操作留下更大的面积。

公开(公告)号：US20240335803A1

公开(公告)日：2024-10-10

申请号：US18434638

申请日：2024-02-06

Applicant: The University of British Columbia

Inventor： Euan Ramsay ,  Robert James Taylor ,  Timothy Leaver ,  Andre Wild ,  Kevin Ou ,  Colin Walsh

IPC: B01F25/431 ,  A61K9/16 ,  B01F25/432 ,  B01F25/433 ,  B01F33/30 ,  B01F33/81 ,  B01F101/22 ,  B01J19/00 ,  G01N15/00 ,  G01N35/00

CPC classification number: B01F25/43161 ,  A61K9/1682 ,  B01F25/4323 ,  B01F25/4331 ,  B01F33/30 ,  B01F33/813 ,  B01J19/0093 ,  B01F25/43172 ,  B01F25/431971 ,  B01F2101/22 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00855 ,  B01J2219/00858 ,  B01J2219/0086 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00894 ,  B01J2219/00898 ,  B01J2219/00986 ,  G01N2015/0038 ,  G01N2035/00158

Abstract: The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

公开(公告)号：US20170165669A1

公开(公告)日：2017-06-15

申请号：US15039637

申请日：2014-11-25

Applicant: Gnubio, Inc.

Inventor： Tony Hung ,  Sepehr Kiani ,  Scott Powers ,  Adnan Esmail

IPC: B01L3/00 ,  B01J19/00

CPC classification number: B01L3/502784 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00792 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/00855 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00894 ,  B01J2219/00903 ,  B01J2219/00934 ,  B01L3/502715 ,  B01L3/502776 ,  B01L7/525 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0858 ,  B01L2300/0867 ,  B01L2400/0487

Abstract: Systems and methods for confining droplets within a microfluidic channel as well as systems and methods for packing droplets are provided. More specifically, a system and method are provided for controlling the introduction and removal of oil into a microfluidic channel in order to control where drops are allowed to flow within that channel.

公开(公告)号：US09023900B2

公开(公告)日：2015-05-05

申请号：US13397942

申请日：2012-02-16

Applicant: Yong Wang ,  Anna Lee Tonkovich ,  Terry Mazanec ,  Francis P. Daly ,  Dave VanderWiel ,  Jianli Hu ,  Chunshe Cao ,  Charles Kibby ,  Xiaohong Li ,  Michael D. Briscoe ,  Nathan Gano ,  Ya-Huei Chin

Inventor： Yong Wang ,  Anna Lee Tonkovich ,  Terry Mazanec ,  Francis P. Daly ,  Dave VanderWiel ,  Jianli Hu ,  Chunshe Cao ,  Charles Kibby ,  Xiaohong Li ,  Michael D. Briscoe ,  Nathan Gano ,  Ya-Huei Chin

IPC: C10G2/00 ,  C07C1/04 ,  B01J19/00 ,  B01J37/03 ,  B01J38/48 ,  B01J23/94 ,  B01J37/02 ,  B01J23/755 ,  B01J23/83 ,  B01J23/889 ,  B01J23/89 ,  B01J35/00 ,  B01J35/04 ,  B01J35/10 ,  C10G45/58 ,  C10G47/00 ,  B01J23/75 ,  B01J21/04 ,  B01J38/58

CPC classification number: C10G2/332 ,  B01J19/0093 ,  B01J23/75 ,  B01J23/755 ,  B01J23/83 ,  B01J23/8896 ,  B01J23/8913 ,  B01J23/892 ,  B01J23/894 ,  B01J23/8986 ,  B01J23/94 ,  B01J35/0066 ,  B01J35/04 ,  B01J35/1019 ,  B01J35/1038 ,  B01J37/0201 ,  B01J37/0205 ,  B01J37/038 ,  B01J38/48 ,  B01J38/58 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00835 ,  B01J2219/00855 ,  B01J2219/0086 ,  B01J2219/00873 ,  C10G2/331 ,  C10G2/334 ,  C10G2/34 ,  C10G2/341 ,  C10G21/00 ,  C10G45/58 ,  C10G47/00 ,  C10G2300/1022 ,  C10G2400/04 ,  C10G2400/10 ,  C10L1/08 ,  C10L2200/0492 ,  C10L2270/026 ,  C10L2290/42 ,  C10L2290/544 ,  C10M105/04 ,  Y02P20/582

Abstract: Disclosed is a process for converting a reactant composition comprising H2 and CO to a product comprising at least one aliphatic hydrocarbon having at least about 5 carbon atoms, the process comprising: flowing the reactant composition through a microchannel reactor in contact with a Fischer-Tropsch catalyst to convert the reactant composition to the product, the microchannel reactor comprising a plurality of process microchannels containing the catalyst; transferring heat from the process microchannels to a heat exchanger; and removing the product from the microchannel reactor; the process producing at least about 0.5 gram of aliphatic hydrocarbon having at least about 5 carbon atoms per gram of catalyst per hour; the selectivity to methane in the product being less than about 25%. Also disclosed is a supported catalyst comprising Co, and a microchannel reactor comprising at least one process microchannel and at least one adjacent heat exchange zone.

Abstract translation: 公开了一种将包含H 2和CO的反应物组合物转化为包含至少一种具有至少约5个碳原子的脂族烃的产物的方法，该方法包括：使反应物组合物流过与费 - 托催化剂接触的微通道反应器 将反应物组合物转化成产物，微通道反应器包含多个含有催化剂的工艺微通道; 将热量从工艺微通道传递到热交换器; 并从微通道反应器中除去产物; 该方法每小时产生至少约0.5克具有至少约5个碳原子的每克催化剂的脂族烃; 产品中甲烷的选择性小于约25％。 还公开了包含Co的载体催化剂和包含至少一个工艺微通道和至少一个相邻的热交换区的微通道反应器。

公开(公告)号：US20140179021A1

公开(公告)日：2014-06-26

申请号：US13992155

申请日：2011-12-06

Applicant: Luke A. Parkinson

Inventor： Luke A. Parkinson

IPC: B01L3/00

CPC classification number: B01L3/502753 ,  B01D11/0496 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00806 ,  B01J2219/00822 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/0084 ,  B01J2219/00853 ,  B01J2219/00855 ,  B01J2219/0086 ,  B01J2219/00907 ,  B01J2219/00988 ,  B01J2219/0099 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/028 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0487 ,  Y10T436/25375

Abstract: A microfluidic element comprising at least one pair of plates, at least one of said plates having an open channel distributed on a surface that is adjacent the other plate in the pair. In use, said plates are releasably clamped together so as to form an enclosed, continuous microfluidic channel between the plates that is suitable for the passage of a fluid.

Abstract translation: 一种微流体元件，包括至少一对板，所述板中的至少一个具有分布在与所述一对中的另一个板相邻的表面上的开放通道。 在使用中，所述板可释放地夹紧在一起，以便在板之间形成适合于流体通过的封闭的，连续的微流体通道。

公开(公告)号：US20130217793A1

公开(公告)日：2013-08-22

申请号：US13397942

申请日：2012-02-16

Applicant: Yong Wang ,  Anna Lee Tonkovich ,  Terry Mazanec ,  Francis P. Daly ,  Dave VanderWiel ,  Jianli Hu ,  Chunshe Cao ,  Charles Kibby ,  Xiaohong Li ,  Michael D. Briscoe ,  Nathan Gano ,  Ya-Huei Chin

Inventor： Yong Wang ,  Anna Lee Tonkovich ,  Terry Mazanec ,  Francis P. Daly ,  Dave VanderWiel ,  Jianli Hu ,  Chunshe Cao ,  Charles Kibby ,  Xiaohong Li ,  Michael D. Briscoe ,  Nathan Gano ,  Ya-Huei Chin

IPC: C07C1/04 ,  B01J23/75 ,  B01J21/04

CPC classification number: C10G2/332 ,  B01J19/0093 ,  B01J23/75 ,  B01J23/755 ,  B01J23/83 ,  B01J23/8896 ,  B01J23/8913 ,  B01J23/892 ,  B01J23/894 ,  B01J23/8986 ,  B01J23/94 ,  B01J35/0066 ,  B01J35/04 ,  B01J35/1019 ,  B01J35/1038 ,  B01J37/0201 ,  B01J37/0205 ,  B01J37/038 ,  B01J38/48 ,  B01J38/58 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00835 ,  B01J2219/00855 ,  B01J2219/0086 ,  B01J2219/00873 ,  C10G2/331 ,  C10G2/334 ,  C10G2/34 ,  C10G2/341 ,  C10G21/00 ,  C10G45/58 ,  C10G47/00 ,  C10G2300/1022 ,  C10G2400/04 ,  C10G2400/10 ,  C10L1/08 ,  C10L2200/0492 ,  C10L2270/026 ,  C10L2290/42 ,  C10L2290/544 ,  C10M105/04 ,  Y02P20/582

Abstract: The disclosed invention relates to a process for converting a reactant composition comprising H2 and CO to a product comprising at least one aliphatic hydrocarbon having at least about 5 carbon atoms, the process comprising: flowing the reactant composition through a microchannel reactor in contact with a Fischer-Tropsch catalyst to convert the reactant composition to the product, the microchannel reactor comprising a plurality of process microchannels containing the catalyst; transferring heat from the process microchannels to a heat exchanger; and removing the product from the microchannel reactor; the process producing at least about 0.5 gram of aliphatic hydrocarbon having at least about 5 carbon atoms per gram of catalyst per hour; the selectivity to methane in the product being less than about 25%. The disclosed invention also relates to a supported catalyst comprising Co, and a microchannel reactor comprising at least one process microchannel and at least one adjacent heat exchange zone.

公开(公告)号：US12017195B2

公开(公告)日：2024-06-25

申请号：US17257816

申请日：2019-07-01

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Quan Qing ,  Ching-wei Tsao ,  Peiming Zhang

IPC: B01J19/00 ,  C07K1/04

CPC classification number: B01J19/0093 ,  B01J19/0046 ,  C07K1/045 ,  B01J2219/00317 ,  B01J2219/00529 ,  B01J2219/00596 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00713 ,  B01J2219/00722 ,  B01J2219/00822 ,  B01J2219/00853 ,  B01J2219/00855

Abstract: The present disclosure provides an apparatus for synthesizing a biopolymer, a method for preparing an apparatus for synthesizing a biopolymer, and a method of synthesizing a biopolymer. The apparatus comprises (a) a substrate comprising atop surface and a plurality of wells, wherein each of the plurality of wells comprises a first electrode disposed on the bottom of the well and a linker attached to the sides of the well; and (b) a fluidic chamber system disposed on the top surface of the substrate.