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1.发明授权公开(公告)号：US11478799B2
公开(公告)日：2022-10-25
申请号：US15926985
申请日：2018-03-20
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng
IPC: B01L3/00 , B01J19/00 , B82Y30/00 , G01N35/08 , B01F25/433 , B01F33/302 , G01N1/28 , B01D9/00 , C07K14/43 , C12N9/36 , C30B7/14 , C30B29/54 , C30B29/58 , B01J14/00 , C12Q1/6806
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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公开(公告)号：US10947282B2
公开(公告)日：2021-03-16
申请号：US15544216
申请日：2016-01-20
Applicant: The Texas A&M University System
Inventor： Sarah Bondos , Kayla Bayless , Kathleen Matthews , Jan Patterson , Colette Abbey , David Howell , Hao-Ching Hsiao , Kelly Churion , Shang-Pu Tsai , Sandhya Ramasamy , Dustin Porterpan , Keira Northern
Abstract: Embodiments of the invention are directed to Ubx-fusion molecules that maintain their mechanical strength and properties even after being fused with Ubx. Ubx fusions with VEGF and other growth factors, cell signaling proteins, and cell binding proteins can be used to induce angiogenesis. Ubx fibers and mesh, embedded within a tissue engineering scaffold, induce formation of vasculature within the scaffold. The presence of vasculature is necessary to provide oxygen and nutrients to other cells growing within the scaffold.
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公开(公告)号：US20200070172A1
公开(公告)日：2020-03-05
申请号：US16555545
申请日：2019-08-29
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng
IPC: B01L3/00 , C12Q1/6806 , B01J14/00 , C30B29/58 , C30B29/54 , C30B7/14 , C12N9/36 , C07K14/43 , B01D9/00 , G01N1/28 , G01N35/08 , B82Y30/00 , B01J19/00 , B01F13/00 , B01F5/06
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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4.发明授权公开(公告)号：US09856308B2
公开(公告)日：2018-01-02
申请号：US14398361
申请日：2013-05-02
Applicant: SPIBER TECHNOLOGIES AB
Inventor： My Hedhammar , Jan Johansson , Anna Rising , Per Åke Nygren
IPC: C07K14/78 , C07K14/43 , C07K16/00 , C07K16/44 , C07K14/435
CPC classification number: C07K14/78 , C07K14/43518 , C07K16/00 , C07K16/44 , C07K2317/35 , C07K2317/56 , C07K2317/569 , C07K2317/622 , C07K2319/00 , C07K2319/30 , C07K2319/70
Abstract: A recombinant fusion protein comprising the moieties Band CT, and optionally REP, wherein B is comprising at least one immunoglobulin fragment, which provides the capacity of selective interaction with an organic target; CT is a moiety of from 70 to 120 amino acid residues and is derived from the C-terminal fragment of a spider silk protein; and REP is a moiety of from 70 to 300 amino acid residues and is derived from the repetitive fragment of a spider silk protein.
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公开(公告)号：US09689089B2
公开(公告)日：2017-06-27
申请号：US14405101
申请日：2013-04-26
Applicant: SPIBER INC.
Inventor： Mizuki Ishikawa , Kazuhide Sekiyama
CPC classification number: D01F4/02 , C07K14/43518 , D01D1/02 , D01D5/04 , D01D5/06 , D01F1/06 , D01F4/00
Abstract: A solution-dyed protein fiber of the present invention includes 0-100 mass % of silk fibroin and 100-0 mass % of a polypeptide derived from spider silk proteins when the protein fiber is assumed to be 100 mass %, wherein the solution-dyed protein fiber contains a solution-dyeing colorant. The fiber is obtained by: dissolving or dispersing a solution-dyeing colorant in a solvent used for a spinning solution or in dimethyl sulfoxide, thereby preparing a coloring liquid; adding a solvent to the coloring liquid in an amount necessary for a spinning solution; adding and dissolving protein powder into the solvent, thereby preparing a spinning solution; and subjecting the spinning solution to wet spinning or dry-wet spinning. Thereby, the present invention provides a low-cost solution-dyed protein fiber in which a solution-dyeing colorant is dispersed uniformly and that can exhibit bright color tone, and a method for producing the same.
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Patent Agency Ranking
公开(公告)号：US5859343A
公开(公告)日：1999-01-12
申请号：US670186
申请日：1996-06-21
Applicant: Samuel S. M. Sun , Liwen Xiong , Zhong Hu , Hang Chen
Inventor： Samuel S. M. Sun , Liwen Xiong , Zhong Hu , Hang Chen
CPC classification number: C12N15/8242 , A23L27/31 , C07K14/43
Abstract: Recombinant materials for the production of practical amounts of the sweet protein, mabinlin are provided. In addition, transgenic plants which have inherently sweetened edible parts result from modifying native plants containing edible parts to express the mabinlin gene. Single-chain forms of this protein which retain their sweetening property are also provided.
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公开(公告)号：US5693493A
公开(公告)日：1997-12-02
申请号：US450731
申请日：1995-05-25
Applicant: Randy R. Robinson , Alvin Y. Liu , Arnold H. Horwitz , Marc Better , Randolph Wall , Shau-Ping Lei , Gary L. Wilcox
Inventor： Randy R. Robinson , Alvin Y. Liu , Arnold H. Horwitz , Marc Better , Randolph Wall , Shau-Ping Lei , Gary L. Wilcox
IPC: A61K38/00 , C07K14/43 , C07K16/30 , C07K16/46 , C12N9/88 , C12N15/70 , C12N15/81 , C12N15/00 , C12P21/04 , C12P21/06
CPC classification number: C12N15/70 , C07K14/43 , C07K16/3046 , C07K16/462 , C12N15/81 , C12N9/88 , A61K38/00 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2319/00 , C07K2319/02 , C07K2319/034 , C07K2319/036 , C07K2319/30
Abstract: The invention relates to cDNA genetic sequences, vehicles containing same as well as hosts transformed therewith, for the production of chimeric immunoglobulin molecules, functional fragments thereof and immunoglobulin derivatives exhibiting novel functional properties comprising human constant region modules and non-human variable region modules, or for class switching antibody molecules and/or chains. The invention also relates to DNA coding for pectate lyase signal peptide has been cloned on a plasmid to create a secretion vector which is capable of producing a chosen protein which is transported across the bacterial membrane. The secretion vector has been used to secrete extracellular thaumatin and extracellular chimeric antibody fragments. The proteins produced by this vector have biological activity. The thaumatin is properly folded and the antibody fragments are capable of binding antigens on target cancer cells. The invention also relates to the secretion of chimeric antibodies and fragments thereof from yeast in functional form.
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公开(公告)号：US5625035A
公开(公告)日：1997-04-29
申请号：US202717
申请日：1994-02-23
Applicant: Gisela K. Clemons
Inventor： Gisela K. Clemons
Abstract: Purified mammalian erythropoietin binding-protein is disclosed, and its isolation, identification, characterization, purification, and immunoassay are described. The erythropoietin binding protein can be used for regulation of erythropoiesis by regulating levels and half-life of erythropoietin. A diagnostic kit for determination of level of erythropoietin binding protein is also described.
Abstract translation: 公开了纯化的哺乳动物促红细胞生成素结合蛋白，并描述了其分离，鉴定，表征，纯化和免疫测定。 促红细胞生成素结合蛋白可以通过调节红细胞生成素的水平和半衰期来用于调节红细胞生成。 还描述了用于测定促红细胞生成素结合蛋白水平的诊断试剂盒。
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公开(公告)号：US5466792A
公开(公告)日：1995-11-14
申请号：US336346
申请日：1994-11-08
Applicant: Jerry L. Slightom , David A. Tepfer
Inventor： Jerry L. Slightom , David A. Tepfer
IPC: C07K14/325 , C07K14/415 , C07K14/42 , C07K14/43 , C12N15/82 , C12N15/84 , C07H17/00
CPC classification number: C07K14/415 , C07K14/325 , C07K14/42 , C07K14/43 , C12N15/8216
Abstract: The sequence of the T.sub.L -DNA of Ri plasmids found in Agrobacterium rhizogenes strains HRI and A4 is disclosed. Sixteen open reading frames bounded by eukaryotic promoters, ribosome binding sites, and polyadenylation sites were found, five of which were observed to be transcripted in a developmentally and phenotypically regulated manner. The use of promoters and polyadenylation sites from pRi T.sub.L -DNA to control expression of heterologous foreign structural genes is taught, using as examples the structural genes for Phaseolus vulgaris storage protein (phaseolin), P. vulgaris lectin, a sweet protein (thaumatin), and Bacillus thuringiensis crystal protein. Vectors useful for manipulation of sequences of the structural genes and T-DNA are also provided.
Abstract translation: 公开了发根农杆菌菌株HRI和A4中发现的Ri质粒的TL-DNA序列。 发现由真核启动子，核糖体结合位点和多聚腺苷酸化位点限制的16个开放阅读框，其中5个被观察到以发育和表型调节的方式转录。 使用来自pRi TL-DNA的启动子和多聚腺苷酸化位点来控制异源外来结构基因的表达，使用菜豆（Phaseolus vulgaris）存储蛋白（菜豆蛋白），普通寻常型凝集素，甜蛋白（马齿苋）， 和苏云金芽孢杆菌晶体蛋白。 还提供了可用于操纵结构基因和T-DNA序列的载体。
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10.发明授权DNA encoding (ASP 113) and (LYS 46, ASP 113) thaumatin I 失效DNA编码（ASP 113）和（LYS 46，ASP 113）thaumatin I
公开(公告)号：US5464770A
公开(公告)日：1995-11-07
申请号：US189250
申请日：1988-05-02
Applicant: Joachim L. Weickmann , Pradip Ghosh-Dastidar
Inventor： Joachim L. Weickmann , Pradip Ghosh-Dastidar
IPC: C12N15/09 , A23L27/00 , C07H15/12 , C07K14/43 , C12N1/00 , C12N1/16 , C12N1/19 , C12N1/20 , C12N1/21 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/865 , C12N15/29
CPC classification number: C07K14/43
Abstract: Genes are disclosed which are capable of directing the synthesis in a selected host microorganism of two thaumatin I analogues both of which have the amino acid sequence of natural thaumatin I including an aspartate amino acid residue in the 113th position from the amino terminal end of the polypeptide and one of which additionally has a lysine amino acid residue substituted for asparagine in the 46th position from the amino terminal end.
Abstract translation: 公开了能够将选择的宿主微生物中合成的基因导入两种thaumatin I类似物，两者都具有天然奇异果甜蛋白I的氨基酸序列，其包含天冬氨酸氨基酸残基在该多肽的氨基末端的第113位 其中一个另外具有在氨基末端的第46位取代天冬酰胺的赖氨酸氨基酸残基。
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