公开(公告)号：US20220106348A1

公开(公告)日：2022-04-07

申请号：US17491518

申请日：2021-09-30

申请人： The Regents of the University of California

发明人： Xi CHEN ,  An XIAO ,  Anoopjit KOONER ,  Abhishek SANTRA ,  Ajit VARKI ,  Hai YU ,  Lee-Ping WANG ,  Wanqing LI

IPC分类号： C07H15/04 ,  C07H15/12 ,  C07H15/14 ,  C07H15/203 ,  C12P19/28 ,  C12P19/44 ,  C12P19/64

摘要： The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.

公开(公告)号：US10813942B2

公开(公告)日：2020-10-27

申请号：US16450649

申请日：2019-06-24

申请人： Pfizer Inc.

发明人： Spiros Liras ,  Vincent Mascitti ,  Benjamin Thuma

IPC分类号： C07D493/08 ,  A61K31/357 ,  A61K31/706 ,  C07D309/14 ,  C07H13/04 ,  C07H15/26 ,  A61K47/64 ,  A61K31/7008 ,  A61K31/7056 ,  A61K38/46 ,  C07H15/08 ,  C07H15/12 ,  C07K5/065

摘要： Compounds of Formula (A) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by pharmaceutical compositions and the uses thereof as asialoglycoprotein receptor (ASGPR) targeting agents.

公开(公告)号：US20200079808A1

公开(公告)日：2020-03-12

申请号：US16493959

申请日：2018-03-15

申请人： POLYNEURON PHARMACEUTICALS AG

发明人： Hélène Blanche PFISTER ,  Ruben HERRENDORFF ,  Beat ERNST

IPC分类号： C07H15/12 ,  A61K47/64 ,  C07H15/04 ,  C07H15/203

摘要： The invention relates to polymers comprising carbohydrate ligands and moieties, respectively, that bind to carbohydrate-binding proteins (CBPs), as well as to these carbohydrate ligands, and to their use in diagnosis and therapy of diseases that are associated with CBP-mediated cytotoxicity, agglutinatination, or immune complex deposit formation. In particular, the invention relates to polymers comprising a multitude of said carbohydrate ligands and moieties, respectively, mimicking carbohydrates that are bound by CBPs which belong to the group of (i) bacterial exotoxins, (ii) agglutinins, and (iii) immune complex deposit-forming immunoglobulins. Furthermore, the invention relates to the use of these polymers and carbohydrate ligands and moieties respectively, in diagnosis as well as for the treatment of diseases that are associated with CBP-mediated cytotoxicity, agglutinatination, or immune complex deposit formation. In one embodiment, the polymer is polylysine.

公开(公告)号：US10335477B2

公开(公告)日：2019-07-02

申请号：US14892237

申请日：2014-05-20

申请人： Yale University

发明人： Jorge E. Galan ,  Jeongmin Song

IPC分类号： A61K39/112 ,  A61K39/39 ,  A61K39/395 ,  C07H15/12 ,  C07K16/40 ,  C12Q1/689 ,  G01N33/569 ,  A61K39/00

摘要： The invention provides compositions and methods for preventing, treating and diagnosing infection by Salmonella enterica serovar typhi (S. typhi) and/or S. paratyphi, i.e., typhoid fever.

公开(公告)号：US10183962B2

公开(公告)日：2019-01-22

申请号：US15119880

申请日：2015-02-24

申请人： MSD WELLCOME TRUST HILLEMAN LABORATORIES PVT. LTD.

发明人： Davinder Gill ,  Kishore Harale ,  Manoj Kumar Chhikara

IPC分类号： C07H15/04 ,  C07H11/04 ,  C08B37/00 ,  C07H15/12 ,  C07H1/00 ,  C07H1/02

摘要： The present invention relates to synthesis of novel higher oligomers and process of preparing the same. In particular the present invention relates to the chemical synthesis of oligomers of Neisseria meningitidis serogroup X (‘hereinafter Men-X), more particularly tetramer. The present invention provides Men-X capsular oligomers obtained from synthetic pathway using purified saccharides of specific chain length and provides said novel oligomers as candidates for the development of conjugate vaccine against bacterial meningitis caused due to Men-X infections.

公开(公告)号：US10105440B2

公开(公告)日：2018-10-23

申请号：US15348881

申请日：2016-11-10

申请人： VARIATION BIOTECHNOLOGIES INC.

发明人： Maura Ellen Campbell

IPC分类号： A61K39/39 ,  A61K39/00 ,  C07H13/04 ,  C07H13/06 ,  A61K39/145 ,  A61K39/112 ,  A61K39/02 ,  A61K39/21 ,  A61K39/29 ,  C07H15/12 ,  A61K39/12 ,  A61K9/00 ,  A61K9/127 ,  A61K9/19

摘要： In one aspect, the present disclosure provides compounds of formulae I and II. In another aspect, a compound of formula I or II is formulated into compositions with an antigen, optionally with a vesicle. In some embodiments, compositions are administered intramuscularly.

公开(公告)号：US20180201652A1

公开(公告)日：2018-07-19

申请号：US15841236

申请日：2017-12-13

申请人： NANYANG TECHNOLOGICAL UNIVERSITY

发明人： Bee Eng Mary Chan ,  Peng Li

IPC分类号： C07K14/00 ,  C07K4/00 ,  A01N43/16 ,  C08L5/08 ,  C07H15/12 ,  C07H13/04 ,  C08L89/00 ,  C08H1/00 ,  C07H15/18 ,  C08B37/08

CPC分类号： C07K14/001 ,  A01N43/16 ,  C07H13/04 ,  C07H15/12 ,  C07H15/18 ,  C07K4/00 ,  C08B37/003 ,  C08H1/00 ,  C08L5/08 ,  C08L89/00

摘要： The disclosure provides cationic peptidopolysaccharides of Formula I: which has a bacterial peptidoglycan-mimetic structure, and shows outstanding broad spectrum activities against clinically significant bacteria and fungi. The structural affinity of these compounds with microbial cell wall constituents promotes its passage to the cytoplasmic membrane resulting in excellent antimicrobial activity and record high selectivity. The disclosure also describes methods of making and using cationic peptidopolysaccharides of Formula I.

公开(公告)号：US20170339949A1

公开(公告)日：2017-11-30

申请号：US15534675

申请日：2015-12-10

申请人： Clariant International Ltd.

发明人： Peter KLUG ,  Franz-Xaver SCHERL ,  George Ítalo Pitombeira NUNES ,  Peter BAUR ,  Roland ARNOLD

IPC分类号： A01N25/30 ,  C07H15/12 ,  A01N41/10

CPC分类号： A01N25/30 ,  A01N41/10 ,  C07C233/20 ,  C07H15/12

摘要： A sugar surfactant of formula (I), where R1 is H or an alkyl group comprising 1 to 3 carbon atoms and R2 is a polyhydroxyhydrocarbyl group comprising a straight hydrocarbyl chain to which at least three hydroxyl groups are directly bonded, preferably a 2,3,4,5,6-pentahydroxyhex-1-yl group, is suitable especially for use in agrochemical adjuvant and active substance compositions.

公开(公告)号：US20160207953A1

公开(公告)日：2016-07-21

申请号：US15093178

申请日：2016-04-07

申请人： Pfizer Inc.

发明人： Spiros Liras ,  Vincent Mascitti ,  Benjamin Thuma

IPC分类号： C07H15/08 ,  A61K31/7008 ,  C07H15/26 ,  A61K38/46 ,  C07H15/12 ,  A61K31/706 ,  C07K5/065 ,  C07H13/04 ,  A61K31/7056

CPC分类号： A61K31/706 ,  A61K31/7008 ,  A61K31/7056 ,  A61K38/465 ,  A61K47/64 ,  C07D309/14 ,  C07D493/08 ,  C07H13/04 ,  C07H15/08 ,  C07H15/12 ,  C07H15/26 ,  C07K5/06078 ,  C12Y301/00 ,  Y02A50/463

摘要： Compounds of Formula (A) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by pharmaceutical compositions and the uses thereof as asialoglycoprotein receptor (ASGPR) targeting agents.

公开(公告)号：US09212245B2

公开(公告)日：2015-12-15

申请号：US13980535

申请日：2012-12-04

申请人： Empire Technology Development LLC

发明人： William B. Carlson ,  Gregory D. Phelan

IPC分类号： C08F24/00 ,  C07H3/02 ,  C07H15/12 ,  C08F220/58 ,  C07H13/04 ,  C07H15/04 ,  C08F222/38

CPC分类号： C08F220/58 ,  C07H13/04 ,  C07H15/04 ,  C08F222/385

摘要： Disclosed are derivatives of (tetrahydropyranyl)methyl acrylamide and polymers derived therefrom, as well as methods of making such compounds and polymers. Adhesives, coatings, and plastics which include such polymers are also described.

摘要翻译： 公开了（四氢吡喃基）甲基丙烯酰胺的衍生物和由其衍生的聚合物，以及制备这种化合物和聚合物的方法。 还描述了包括这种聚合物的粘合剂，涂料和塑料。