-
公开(公告)号：US10330631B2
公开(公告)日：2019-06-25
申请号：US14815228
申请日：2015-07-31
IPC分类号： G01N27/327 , C12Q1/6869 , G01N21/64 , G01N33/487 , G01N30/88 , B82Y15/00
摘要： A nanoscale-sized pore positioned between two reservoirs may sequence biomolecules by detecting changes in the emitted light due to a change in charge of portions of the biomolecules as they pass through the pore such as affect an emission frequency of a quantum structure proximate to the pore opening. The nanopores may be fabricated using local droplet etching whose randomness is accommodated by lowering the droplet density to permit isolation of nanopores in tiles that may be adhered to an underlying supporting substrate having an aligned opening. The nanopore-tiles may be integrated with commonly applied glass chips and may be employed in microfluidic circuitry.
-
公开(公告)号：US09322820B2
公开(公告)日：2016-04-26
申请号：US13828230
申请日：2013-03-14
发明人： Robert H. Blick , Eric James Stava
IPC分类号： G01N27/00 , G01N33/487 , G01N15/12
CPC分类号： G01N33/48721 , C12Q1/6869 , G01N15/12 , G01N15/1218 , G01N15/1227
摘要： A piezoelectric substrate having a nanopore opening that separates two reservoirs of conductive fluid may provide for sensitive biological measurements by allowing control of the size of the nanopore according to piezoelectric stimulation of the substrate. Multiple embodiments are provided of monolithic piezoelectric substrates and nanopores for this purpose as well as a control system for controlling the nanopore dimensions electrically using AC or DC waveforms.
摘要翻译： 具有分离两个导电流体储存器的纳米孔开口的压电基片可以通过根据基底的压电刺激来控制纳米孔的尺寸来提供灵敏的生物学测量。 提供了用于此目的的单片压电基片和纳米孔的多个实施例，以及用AC或DC波形电控制纳米孔尺寸的控制系统。
-
公开(公告)号：US20140266147A1
公开(公告)日：2014-09-18
申请号：US13828230
申请日：2013-03-14
发明人： Robert H. Blick , Eric James Stava
IPC分类号： G01N27/00
CPC分类号： G01N33/48721 , C12Q1/6869 , G01N15/12 , G01N15/1218 , G01N15/1227
摘要： A piezoelectric substrate having a nanopore opening that separates two reservoirs of conductive fluid may provide for sensitive biological measurements by allowing control of the size of the nanopore according to piezoelectric stimulation of the substrate. Multiple embodiments are provided of monolithic piezoelectric substrates and nanopores for this purpose as well as a control system for controlling the nanopore dimensions electrically using AC or DC waveforms.
摘要翻译： 具有分离两个导电流体储存器的纳米孔开口的压电基片可以通过根据基底的压电刺激来控制纳米孔的尺寸来提供灵敏的生物学测量。 提供了用于此目的的单片压电基片和纳米孔的多个实施例，以及用AC或DC波形电控制纳米孔尺寸的控制系统。
-
公开(公告)号：US20140254856A1
公开(公告)日：2014-09-11
申请号：US13785551
申请日：2013-03-05
发明人： Robert H. Blick , Burke S. Richmond
IPC分类号： H04R1/10
CPC分类号： H04R25/606 , A61B2562/0204 , A61B2562/028 , A61B2562/164 , A61B2562/166 , H04R25/554 , H04R25/75 , H04R2225/51
摘要： A flexible membrane of piezoelectric material sized to be supported by and to conform to the eardrum. Electrodes on the membrane allow the membrane to function as an audio transducer stimulating the eardrum with an audio signal or detecting audio signals at the eardrum. Applications may include detecting a variety of pathophysiological and biomechanical features of the tissues of the tympanic membrane and regional integrated anatomy, detecting audio, physical and biological signals, and/or delivery a variety of therapeutic modalities.
摘要翻译： 压电材料的柔性膜的尺寸设计成由鼓膜支撑并符合鼓膜。 膜上的电极允许膜用作用音频信号刺激耳膜的音频传感器或者在鼓膜上检测音频信号。 应用可以包括检测鼓膜组织和区域综合解剖结构的各种病理生理和生物力学特征，检测音频，物理和生物信号，和/或递送多种治疗方式。
-
公开(公告)号：US20140253153A1
公开(公告)日：2014-09-11
申请号：US13786880
申请日：2013-03-06
发明人： Robert H. Blick , Abhishek Bhat
IPC分类号： G01R27/02
CPC分类号： G01N33/48728 , G01R19/0061 , G01R23/00 , G01R31/31708
摘要： An antenna is used for radio frequency measurements of cell wall impedance changes due to ion channels. The antenna provides enhanced direct readout of lipid bilayers and cells containing pores and ion channels. The antenna is placed around a nanopore, which may be fabricated from glass, quartz or other material, and is shaped to provide an enhanced sensitivity to electrical activity in the vicinity of the nanopore. As such, the antenna may be of a class of bi-cone- or other stub-antennas providing high gain and broad bandwidth, for example a planar variant of a “bow-tie” antenna. Accordingly, improved sensitivity of at least an order of magnitude may be achieved over past systems.
摘要翻译： 天线用于由离子通道引起的细胞壁阻抗变化的射频测量。 天线提供增强的脂质双层和含有孔和离子通道的细胞的直接读出。 天线放置在可以由玻璃，石英或其他材料制成的纳米孔周围，并且被成形为对纳米孔附近的电活动提供增强的灵敏度。 因此，天线可以是一类提供高增益和宽带宽的双锥或其它短截线天线，例如“蝴蝶结”天线的平面变体。 因此，可以在以前的系统中实现至少一个数量级的改善的灵敏度。
-
公开(公告)号：US11864465B2
公开(公告)日：2024-01-02
申请号：US16881305
申请日：2020-05-22
IPC分类号： H01L41/312 , H10N30/072 , H10N30/20 , H10N30/80 , H10N30/87 , H10N30/853
CPC分类号： H10N30/072 , H10N30/206 , H10N30/802 , H10N30/8554 , H10N30/875
摘要： Piezoelectrically actuated devices constructed from thin semiconductor membranes bonded directly to piezoelectric substrates are provided. Methods for fabricating these devices are also provided. The bonding of the semiconductor to the piezoelectric material does not require the use of any intermediate layers, such as bonding agents.
-
公开(公告)号：US20200092666A1
公开(公告)日：2020-03-19
申请号：US16130564
申请日：2018-09-13
发明人： Max Lagally , Abhishek Bhat , Frank Flack , Shelley Scott , Robert H. Blick
摘要： A transducer supported by the eardrum provides a piezoelectric material exchanging energy with the eardrum through a nanoscale membrane, the latter serving to boost the coupling between the piezoelectric material and the eardrum
-
公开(公告)号：US09532150B2
公开(公告)日：2016-12-27
申请号：US13785551
申请日：2013-03-05
发明人： Robert H. Blick , Burke S. Richmond
IPC分类号： H04R25/00
CPC分类号： H04R25/606 , A61B2562/0204 , A61B2562/028 , A61B2562/164 , A61B2562/166 , H04R25/554 , H04R25/75 , H04R2225/51
摘要： A flexible membrane of piezoelectric material sized to be supported by and to conform to the eardrum. Electrodes on the membrane allow the membrane to function as an audio transducer stimulating the eardrum with an audio signal or detecting audio signals at the eardrum. Applications may include detecting a variety of pathophysiological and biomechanical features of the tissues of the tympanic membrane and regional integrated anatomy, detecting audio, physical and biological signals, and/or delivery a variety of therapeutic modalities.
摘要翻译： 压电材料的柔性膜的尺寸设计成由鼓膜支撑并符合鼓膜。 膜上的电极允许膜用作用音频信号刺激耳膜的音频传感器或者在鼓膜上检测音频信号。 应用可以包括检测鼓膜组织和区域综合解剖结构的各种病理生理和生物力学特征，检测音频，物理和生物信号，和/或递送多种治疗方式。
-
公开(公告)号：US08581306B2
公开(公告)日：2013-11-12
申请号：US13769723
申请日：2013-02-18
发明人： Robert H. Blick , Chulki Kim , Jonghoo Park
IPC分类号： H01L29/76
CPC分类号： H02M7/04 , H01Q1/248 , H01Q1/38 , H01Q9/27 , H01Q21/061
摘要： A nanoscale electron shuttle with two elastically mounted conductors positioned within a gap between conductors produces asymmetrical electron conduction between the conductors when the conductors receive an AC signal to provide for rectification, detection and/or power harvesting.
摘要翻译： 当导体接收到AC信号以提供整流，检测和/或功率采集时，具有位于导体间隙内的两个弹性安装导体的纳米级电子穿梭件在导体之间产生不对称电子传导。
-
公开(公告)号：US20130182481A1
公开(公告)日：2013-07-18
申请号：US13769723
申请日：2013-02-18
发明人： Robert H. Blick , Chulki Kim , Jonghoo Park
IPC分类号： H02M7/04
CPC分类号： H02M7/04 , H01Q1/248 , H01Q1/38 , H01Q9/27 , H01Q21/061
摘要： A nanoscale electron shuttle with two elastically mounted conductors positioned within a gap between conductors produces asymmetrical electron conduction between the conductors when the conductors receive an AC signal to provide for rectification, detection and/or power harvesting.
摘要翻译： 当导体接收到AC信号以提供整流，检测和/或功率采集时，具有位于导体间隙内的两个弹性安装导体的纳米级电子穿梭件在导体之间产生不对称电子传导。
-
-
-
-
-
-
-
-
-
搜索结果
26 条记录 (耗时 0.019 秒)
