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公开(公告)号：US11698363B2
公开(公告)日：2023-07-11
申请号：US16632296
申请日：2018-07-16
发明人： Robert Blick , Paul Gwozdz , Abhishek Bhat
IPC分类号： G01N33/487 , C12Q1/6869 , G01N33/58 , G01N27/447 , G01N15/00
CPC分类号： G01N33/48721 , C12Q1/6869 , G01N33/588 , G01N27/44791 , G01N2015/0065
摘要： A method to determine the throughput speed v of a pore, comprising the steps of feeding, by means of a driving force F, a filiform calibration element through the pore, the calibration element having a plurality of markers spaced apart by known distances and configured to produce an interaction event that transmits a signal away from the pore upon interaction with the pore, detecting a plurality of interaction events, and determining a time interval Δt between successive interaction events, and/or a frequency ω of interaction events.
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公开(公告)号：US10330631B2
公开(公告)日：2019-06-25
申请号：US14815228
申请日：2015-07-31
IPC分类号： G01N27/327 , C12Q1/6869 , G01N21/64 , G01N33/487 , G01N30/88 , B82Y15/00
摘要： A nanoscale-sized pore positioned between two reservoirs may sequence biomolecules by detecting changes in the emitted light due to a change in charge of portions of the biomolecules as they pass through the pore such as affect an emission frequency of a quantum structure proximate to the pore opening. The nanopores may be fabricated using local droplet etching whose randomness is accommodated by lowering the droplet density to permit isolation of nanopores in tiles that may be adhered to an underlying supporting substrate having an aligned opening. The nanopore-tiles may be integrated with commonly applied glass chips and may be employed in microfluidic circuitry.
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公开(公告)号：US20140253153A1
公开(公告)日：2014-09-11
申请号：US13786880
申请日：2013-03-06
发明人： Robert H. Blick , Abhishek Bhat
IPC分类号： G01R27/02
CPC分类号： G01N33/48728 , G01R19/0061 , G01R23/00 , G01R31/31708
摘要： An antenna is used for radio frequency measurements of cell wall impedance changes due to ion channels. The antenna provides enhanced direct readout of lipid bilayers and cells containing pores and ion channels. The antenna is placed around a nanopore, which may be fabricated from glass, quartz or other material, and is shaped to provide an enhanced sensitivity to electrical activity in the vicinity of the nanopore. As such, the antenna may be of a class of bi-cone- or other stub-antennas providing high gain and broad bandwidth, for example a planar variant of a “bow-tie” antenna. Accordingly, improved sensitivity of at least an order of magnitude may be achieved over past systems.
摘要翻译： 天线用于由离子通道引起的细胞壁阻抗变化的射频测量。 天线提供增强的脂质双层和含有孔和离子通道的细胞的直接读出。 天线放置在可以由玻璃，石英或其他材料制成的纳米孔周围，并且被成形为对纳米孔附近的电活动提供增强的灵敏度。 因此，天线可以是一类提供高增益和宽带宽的双锥或其它短截线天线，例如“蝴蝶结”天线的平面变体。 因此，可以在以前的系统中实现至少一个数量级的改善的灵敏度。
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公开(公告)号：US11588456B2
公开(公告)日：2023-02-21
申请号：US16882591
申请日：2020-05-25
发明人： Max G. Lagally , Matthew McLean Dwyer , Daniel Warren van der Weide , Abhishek Bhat , Francesca Cavallo , Divya Jyoti Prakash
摘要： Traveling-wave tube amplifiers and methods for making slow-wave structures for the amplifiers are provided. The SWSs include helical conductors that are self-assembled via the release of stressed electrically conductive strips from a sacrificial material. The helical conductors can be electroplated post-self-assembly to fortify the helix, reduce losses, and tailor the dimensions and operating parameters of the helix.
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公开(公告)号：US10605800B2
公开(公告)日：2020-03-31
申请号：US15926265
申请日：2018-03-20
发明人： Robert H. Blick , Abhishek Bhat , Paul Gwozdz
IPC分类号： G01N33/487 , C12Q1/6869 , G01N27/22
摘要： A molecule sequencer uses a planar nanochannel for aligning molecules to flow past impedance interrogation electrodes mounted across the channel for rapid sequencing. The electrodes may be fixed to the channel walls to provide improved registration by co-fabrication with the channel. Extended channel length over normally used nanopores can provide improved control of longer molecules and allow parallel sequencers to be readily fabricated on a single substrate.
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公开(公告)号：US20160025655A1
公开(公告)日：2016-01-28
申请号：US14444079
申请日：2014-07-28
发明人： Robert H. Blick , Abhishek Bhat , Paul Gwozdz
CPC分类号： G01N33/48721 , C12Q1/6869 , G01N22/00 , G01R23/02 , G01R27/26
摘要： An electrically conductive nanoscale pore may be employed as an antenna to provide precise localized measurements of the impedance-altering characteristics of a molecule such as DNA or RNA or the like passing through the pore. The use of radiofrequency measurements promises high-speed analysis of long molecules (polymers).
摘要翻译： 可以使用导电的纳米尺度孔作为天线，以提供通过孔的分子例如DNA或RNA等的阻抗变化特性的精确局部测量。 使用射频测量可以高分辨长分子（聚合物）。
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公开(公告)号：US20210367138A1
公开(公告)日：2021-11-25
申请号：US16881305
申请日：2020-05-22
IPC分类号： H01L41/312 , H01L41/04 , H01L41/047 , H01L41/09 , H01L41/187
摘要： Piezoelectrically actuated devices constructed from thin semiconductor membranes bonded directly to piezoelectric substrates are provided. Methods for fabricating these devices are also provided. The bonding of the semiconductor to the piezoelectric material does not require the use of any intermediate layers, such as bonding agents.
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公开(公告)号：US20190293623A1
公开(公告)日：2019-09-26
申请号：US15926265
申请日：2018-03-20
发明人： Robert H. Blick , Abhishek Bhat , Paul Gwozdz
IPC分类号： G01N33/487 , G01N27/22 , C12Q1/6869
摘要： A molecule sequencer uses a planar nanochannel for aligning molecules to flow past impedance interrogation electrodes mounted across the channel for rapid sequencing. The electrodes may be fixed to the channel walls to provide improved registration by co-fabrication with the channel. Extended channel length over normally used nanopores can provide improved control of longer molecules and allow parallel sequencers to be readily fabricated on a single substrate.
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公开(公告)号：US09488600B2
公开(公告)日：2016-11-08
申请号：US14444079
申请日：2014-07-28
发明人： Robert H. Blick , Abhishek Bhat , Paul Gwozdz
CPC分类号： G01N33/48721 , C12Q1/6869 , G01N22/00 , G01R23/02 , G01R27/26
摘要： An electrically conductive nanoscale sensor includes a nanoscale pore that may be employed as a first antenna to provide precise localized measurements of the impedance-altering characteristics of a molecule such as DNA or RNA or the like passing through the pore. The use of radiofrequency measurements via a second antenna communicating with the first antenna promises high-speed analysis of long molecules (polymers).
摘要翻译： 导电纳米级传感器包括纳米尺度孔，其可以用作第一天线，以提供通过孔的分子例如DNA或RNA等的阻抗变化特征的精确局部测量。 通过与第一天线通信的第二天线的射频测量的使用将有助于长分子（聚合物）的高速分析。
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公开(公告)号：US09086401B2
公开(公告)日：2015-07-21
申请号：US13786880
申请日：2013-03-06
发明人： Robert H. Blick , Abhishek Bhat
IPC分类号： G01R23/00 , G01R27/08 , G01N33/487 , G01R31/317 , G01R19/00
CPC分类号： G01N33/48728 , G01R19/0061 , G01R23/00 , G01R31/31708
摘要： An antenna is used for radio frequency measurements of cell wall impedance changes due to ion channels. The antenna provides enhanced direct readout of lipid bilayers and cells containing pores and ion channels. The antenna is placed around a nanopore, which may be fabricated from glass, quartz or other material, and is shaped to provide an enhanced sensitivity to electrical activity in the vicinity of the nanopore. As such, the antenna may be of a class of bi-cone- or other stub-antennas providing high gain and broad bandwidth, for example a planar variant of a “bow-tie” antenna. Accordingly, improved sensitivity of at least an order of magnitude may be achieved over past systems.
摘要翻译： 天线用于由离子通道引起的细胞壁阻抗变化的射频测量。 天线提供增强的脂质双层和含有孔和离子通道的细胞的直接读出。 天线放置在可以由玻璃，石英或其他材料制成的纳米孔周围，并且被成形为对纳米孔附近的电活动提供增强的灵敏度。 因此，天线可以是一类提供高增益和宽带宽的双锥或其它短截线天线，例如“蝴蝶结”天线的平面变体。 因此，可以在以前的系统中实现至少一个数量级的改善的灵敏度。
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