公开(公告)号：US20240132604A1

公开(公告)日：2024-04-25

申请号：US18489983

申请日：2023-10-18

Applicant: iBio, Inc.

Inventor： Dillon Phan ,  Tom Sih-Yuan Hsu ,  Tam Thi Thanh Phuong ,  Matthew P. Greving ,  Alexander Tomoaki Taguchi ,  Cory Schwartz ,  Jiang Chen ,  Gao Liu ,  Martin Brenner ,  Matthew William Dent ,  Cody Allen Moore

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2866 ,  A61P35/00 ,  A61K2039/505

Abstract: Provided herein are anti-CCR8 antibodies or antigen binding fragment thereof, which bind to CCR8, wherein the CCR8 is a human CCR8 and the antibody does not bind human CCR4. The anti-CCR8 antibodies or antigen binding fragment of the disclosure are useful for the treatment of cancer diseases through the elimination of regulatory T cells. Also provided herein are methods of use for the anti-CCR8 antibodies or antigen binding fragment thereof.

公开(公告)号：US20250019457A1

公开(公告)日：2025-01-16

申请号：US18758187

申请日：2024-06-28

Applicant: iBio, Inc.

Inventor： Dillon Phan ,  Cory Schwartz ,  Matthew P. Greving ,  Cody A. Moore ,  Tam Thi Thanh Phuong ,  Matthew Dent ,  Alexander T. Taguchi ,  Jiang Chen ,  Tom Sih-Yuan Hsu ,  Domyoung Kim ,  Martin Brenner

IPC: C07K16/30 ,  C07K16/28

Abstract: Provided herein are anti-Trop 2 antibodies or binding fragments thereof that bind Trop 2, e.g., human Trop 2. The anti-Trop 2 antibodies of the disclosure are useful for the treatment of proliferative disorders or cells that express Trop 2 or mutant Trop 2. Also provided herein are methods of use for the anti-Trop 2 antibodies or binding fragments thereof, as well as bi-valent or multi-valent anti-Trop 2 antibodies or binding fragments thereof that may form complexes that attract immune effectors or binding to other cells, such as, a second antibody, antigen-binding of the second antibody or fragment thereof; a target-binding protein, a cytokine; a lectin; or a toxin.

公开(公告)号：US12129302B2

公开(公告)日：2024-10-29

申请号：US17821295

申请日：2022-08-22

Applicant: iBio, Inc.

Inventor： Dillon Phan ,  Martin Brenner ,  Brian Berquist ,  Peter Kipp ,  Tam Phuong ,  Kevin Babilonia ,  Tom Hsu ,  Lufei Hu ,  James Talmage Taylor, Jr. ,  Cory Schwartz

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2866 ,  A61P35/00 ,  C07K2317/24 ,  C07K2317/567 ,  C07K2317/732 ,  C07K2317/92

Abstract: Materials and methods for using polypeptides containing fragments and variants of the antibody(ies) or portion(s) thereof that bind CD25 to treat cancer alone or in combination with other anti-neoplastic agents.

公开(公告)号：US20230159646A1

公开(公告)日：2023-05-25

申请号：US17821295

申请日：2022-08-22

Applicant: iBio, Inc.

Inventor： Dillon Phan ,  Martin Brenner ,  Brian Berquist ,  Peter Kipp ,  Tam Phuong ,  Kevin Babilonia ,  Tom Hsu ,  Lufei Hu ,  James Talmage Taylor, JR. ,  Cory Schwartz

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2866 ,  A61P35/00 ,  C07K2317/24 ,  C07K2317/92 ,  C07K2317/567 ,  C07K2317/732

Abstract: Materials and methods for using polypeptides containing fragments and variants of the antibody(ies) or portion(s) thereof that bind CD25 to treat cancer alone or in combination with other anti-neoplastic agents.

公开(公告)号：US20250034267A1

公开(公告)日：2025-01-30

申请号：US18824372

申请日：2024-09-04

Applicant: iBio, Inc.

Inventor： Dillon Phan ,  Martin Brenner ,  Brian Berquist ,  Peter Kipp ,  Tam Phuong ,  Kevin Babilonia ,  Tom Hsu ,  Lufei Hu ,  James Talmage Taylor, JR. ,  Cory Schwartz

IPC: C07K16/28 ,  A61P35/00

Abstract: Materials and methods for using polypeptides containing fragments and variants of the antibody(ies) or portion(s) thereof that bind CD25 to treat cancer alone or in combination with other anti-neoplastic agents.

公开(公告)号：US20240228637A9

公开(公告)日：2024-07-11

申请号：US18489983

申请日：2023-10-19

Applicant: iBio, Inc.

Inventor： Dillon Phan ,  Tom Sih-Yuan Hsu ,  Tam Thi Thanh Phuong ,  Matthew P. Greving ,  Alexander Tomoaki Taguchi ,  Cory Schwartz ,  Jiang Chen ,  Gao Liu ,  Martin Brenner ,  Matthew William Dent ,  Cody Allen Moore

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2866 ,  A61P35/00 ,  A61K2039/505

Abstract: Provided herein are anti-CCR8 antibodies or antigen binding fragment thereof, which bind to CCR8, wherein the CCR8 is a human CCR8 and the antibody does not bind human CCR4. The anti-CCR8 antibodies or antigen binding fragment of the disclosure are useful for the treatment of cancer diseases through the elimination of regulatory T cells. Also provided herein are methods of use for the anti-CCR8 antibodies or antigen binding fragment thereof.

公开(公告)号：US20240117056A1

公开(公告)日：2024-04-11

申请号：US18484635

申请日：2023-10-11

Applicant: iBio, Inc.

Inventor： Dillon Phan ,  Tom Sih-Yuan Hsu ,  Matthew P. Greving ,  Martin Brenner ,  Tam Thi Thanh Phuong ,  Alexander Tomoaki Taguchi ,  Cory Schwartz ,  Gao Liu ,  Jiang Chen

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2863 ,  A61P35/00 ,  A61K2039/505

Abstract: Provided herein are anti-EGFRvII antibodies and binding fragments thereof. The anti-EGFRvIII antibodies of the disclosure are useful for the treatment of cancers through, e.g., antibody-dependent cell cytotoxicity (ADCC). Also provided herein are methods of making and using the anti-EGFRvIII antibodies for the treatment of cancer, and polynucleotides that encode the same.