Invention Application
- Patent Title: MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA
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Application No.: US16150185Application Date: 2018-10-02
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Publication No.: US20190031705A1Publication Date: 2019-01-31
- Inventor: Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
- Applicant: The Trustees of Columbia University in the City of New York
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Main IPC: C07H19/14
- IPC: C07H19/14 ; C12Q1/6869 ; C07H19/10 ; C12Q1/6874 ; C12Q1/6876 ; C12Q1/6872 ; C12Q1/68 ; C12Q1/686

Abstract:
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
Public/Granted literature
- US10435742B2 Massive parallel method for decoding DNA and RNA Public/Granted day:2019-10-08
Information query
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