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公开(公告)号：US11001603B2
公开(公告)日：2021-05-11
申请号：US17009590
申请日：2020-09-01
发明人： Laurent Pierre Paul Debien , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号： A01N43/04 , A61K31/70 , C07H19/23 , A61K31/7076 , C07H19/16 , C07H19/20 , C07H19/207 , C07F9/6561 , C07H19/04 , A61K31/706 , A61K45/06 , A61K31/7052 , A61K31/7064 , C07H19/14
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US11667662B2
公开(公告)日：2023-06-06
申请号：US17206896
申请日：2021-03-19
发明人： Laurent Pierre Paul Debien , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ui Sharif
IPC分类号： A01N43/04 , A61K31/70 , C07H19/23 , A61K31/7076 , C07H19/16 , C07H19/20 , C07H19/207 , C07F9/6561 , C07H19/04 , A61K31/706 , A61K45/06 , A61K31/7052 , A61K31/7064 , C07H19/14
CPC分类号： C07H19/23 , A61K31/70 , A61K31/706 , A61K31/7052 , A61K31/7064 , A61K31/7076 , A61K45/06 , C07F9/6561 , C07F9/65616 , C07H19/04 , C07H19/14 , C07H19/16 , C07H19/20 , C07H19/207 , A61K31/7076 , A61K2300/00 , A61K31/7064 , A61K2300/00 , A61K31/706 , A61K2300/00
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US11058704B2
公开(公告)日：2021-07-13
申请号：US16338975
申请日：2017-10-02
发明人： Laurent Pierre Paul Debien , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号： A01N43/04 , A61K31/70 , A61K31/7076 , A61K31/706 , A61K31/7064 , A61K39/395 , C07H19/20 , C07H19/207 , C07H19/23
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US10239912B2
公开(公告)日：2019-03-26
申请号：US15400748
申请日：2017-01-06
发明人： Laurent Pierre Paul Debien , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号： A61K31/70 , A01N43/04 , C07H19/23 , A61K31/7052 , A61K31/7076 , C07H19/16 , C07H19/20 , C07H19/207 , A61K31/7064 , C07H19/14 , C07F9/6561 , C07H19/04
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US20240352057A1
公开(公告)日：2024-10-24
申请号：US18516459
申请日：2023-11-21
发明人： Laurent Pierre Paul DEBIEN , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ui Sharif
IPC分类号： C07H19/23 , A61K31/70 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7076 , A61K45/06 , C07F9/6561 , C07H19/04 , C07H19/14 , C07H19/16 , C07H19/20 , C07H19/207
CPC分类号： C07H19/23 , A61K31/70 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7076 , A61K45/06 , C07F9/6561 , C07F9/65616 , C07H19/04 , C07H19/14 , C07H19/16 , C07H19/20 , C07H19/207
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US10981944B2
公开(公告)日：2021-04-20
申请号：US16273843
申请日：2019-02-12
发明人： Laurent Pierre Paul Debien , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号： A01N43/04 , A61K31/70 , C07H19/23 , A61K31/7076 , C07H19/16 , C07H19/20 , C07H19/207 , C07F9/6561 , C07H19/04 , A61K31/706 , A61K45/06 , A61K31/7052 , A61K31/7064 , C07H19/14
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US20240285665A1
公开(公告)日：2024-08-29
申请号：US18629820
申请日：2024-04-08
发明人： Laurent Pierre Paul DEBIEN , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan UI Sharif
IPC分类号： A61K31/7076 , A61K31/706 , A61K31/7064 , A61K39/395 , C07H19/20 , C07H19/207 , C07H19/23
CPC分类号： A61K31/7076 , A61K31/706 , A61K31/7064 , A61K39/3955 , C07H19/20 , C07H19/207 , C07H19/23
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US11267845B2
公开(公告)日：2022-03-08
申请号：US16461649
申请日：2017-11-17
发明人： Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Ehesan Ul Sharif
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US20190309010A1
公开(公告)日：2019-10-10
申请号：US16273843
申请日：2019-02-12
发明人： Laurent Pierre Paul DEBIEN , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号： C07H19/23 , A61K31/706 , A61K45/06 , C07H19/207 , C07H19/20 , C07H19/16 , A61K31/7076 , A61K31/70 , C07F9/6561 , C07H19/14 , A61K31/7064 , A61K31/7052 , C07H19/04
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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