公开(公告)号：US11667662B2

公开(公告)日：2023-06-06

申请号：US17206896

申请日：2021-03-19

Applicant: ARCUS BIOSCIENCES, INC.

Inventor： Laurent Pierre Paul Debien ,  Juan Carlos Jaen ,  Jaroslaw Kalisiak ,  Kenneth V. Lawson ,  Manmohan Reddy Leleti ,  Erick Allen Lindsey ,  Dillon Harding Miles ,  Eric Newcomb ,  Jay Patrick Powers ,  Brandon Reid Rosen ,  Ehesan Ui Sharif

IPC: A01N43/04 ,  A61K31/70 ,  C07H19/23 ,  A61K31/7076 ,  C07H19/16 ,  C07H19/20 ,  C07H19/207 ,  C07F9/6561 ,  C07H19/04 ,  A61K31/706 ,  A61K45/06 ,  A61K31/7052 ,  A61K31/7064 ,  C07H19/14

CPC classification number: C07H19/23 ,  A61K31/70 ,  A61K31/706 ,  A61K31/7052 ,  A61K31/7064 ,  A61K31/7076 ,  A61K45/06 ,  C07F9/6561 ,  C07F9/65616 ,  C07H19/04 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C07H19/207 ,  A61K31/7076 ,  A61K2300/00 ,  A61K31/7064 ,  A61K2300/00 ,  A61K31/706 ,  A61K2300/00

Abstract: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.

公开(公告)号：US20240352057A1

公开(公告)日：2024-10-24

申请号：US18516459

申请日：2023-11-21

Applicant: Arcus Biosciences, Inc.

Inventor： Laurent Pierre Paul DEBIEN ,  Juan Carlos Jaen ,  Jaroslaw Kalisiak ,  Kenneth V. Lawson ,  Manmohan Reddy Leleti ,  Erick Allen Lindsey ,  Dillon Harding Miles ,  Eric Newcomb ,  Jay Patrick Powers ,  Brandon Reid Rosen ,  Ehesan Ui Sharif

IPC: C07H19/23 ,  A61K31/70 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7076 ,  A61K45/06 ,  C07F9/6561 ,  C07H19/04 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C07H19/207

CPC classification number: C07H19/23 ,  A61K31/70 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7076 ,  A61K45/06 ,  C07F9/6561 ,  C07F9/65616 ,  C07H19/04 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C07H19/207

Abstract: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.

公开(公告)号：US10981944B2

公开(公告)日：2021-04-20

申请号：US16273843

申请日：2019-02-12

Applicant: ARCUS BIOSCIENCES, INC.

Inventor： Laurent Pierre Paul Debien ,  Juan Carlos Jaen ,  Jaroslaw Kalisiak ,  Kenneth V. Lawson ,  Manmohan Reddy Leleti ,  Erick Allen Lindsey ,  Dillon Harding Miles ,  Eric Newcomb ,  Jay Patrick Powers ,  Brandon Reid Rosen ,  Ehesan Ul Sharif

IPC: A01N43/04 ,  A61K31/70 ,  C07H19/23 ,  A61K31/7076 ,  C07H19/16 ,  C07H19/20 ,  C07H19/207 ,  C07F9/6561 ,  C07H19/04 ,  A61K31/706 ,  A61K45/06 ,  A61K31/7052 ,  A61K31/7064 ,  C07H19/14

Abstract: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.

公开(公告)号：US10239912B2

公开(公告)日：2019-03-26

申请号：US15400748

申请日：2017-01-06

Applicant: ARCUS BIOSCIENCES, INC.

Inventor： Laurent Pierre Paul Debien ,  Juan Carlos Jaen ,  Jaroslaw Kalisiak ,  Kenneth V. Lawson ,  Manmohan Reddy Leleti ,  Erick Allen Lindsey ,  Dillon Harding Miles ,  Eric Newcomb ,  Jay Patrick Powers ,  Brandon Reid Rosen ,  Ehesan Ul Sharif

IPC: A61K31/70 ,  A01N43/04 ,  C07H19/23 ,  A61K31/7052 ,  A61K31/7076 ,  C07H19/16 ,  C07H19/20 ,  C07H19/207 ,  A61K31/7064 ,  C07H19/14 ,  C07F9/6561 ,  C07H19/04

Abstract: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.

公开(公告)号：US11001603B2

公开(公告)日：2021-05-11

申请号：US17009590

申请日：2020-09-01

Applicant: ARCUS BIOSCIENCES, INC.

Inventor： Laurent Pierre Paul Debien ,  Juan Carlos Jaen ,  Jaroslaw Kalisiak ,  Kenneth V. Lawson ,  Manmohan Reddy Leleti ,  Erick Allen Lindsey ,  Dillon Harding Miles ,  Eric Newcomb ,  Jay Patrick Powers ,  Brandon Reid Rosen ,  Ehesan Ul Sharif

IPC: A01N43/04 ,  A61K31/70 ,  C07H19/23 ,  A61K31/7076 ,  C07H19/16 ,  C07H19/20 ,  C07H19/207 ,  C07F9/6561 ,  C07H19/04 ,  A61K31/706 ,  A61K45/06 ,  A61K31/7052 ,  A61K31/7064 ,  C07H19/14

Abstract: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.

公开(公告)号：US20190309010A1

公开(公告)日：2019-10-10

申请号：US16273843

申请日：2019-02-12

Applicant: Arcus Biosciences, Inc.

Inventor： Laurent Pierre Paul DEBIEN ,  Juan Carlos Jaen ,  Jaroslaw Kalisiak ,  Kenneth V. Lawson ,  Manmohan Reddy Leleti ,  Erick Allen Lindsey ,  Dillon Harding Miles ,  Eric Newcomb ,  Jay Patrick Powers ,  Brandon Reid Rosen ,  Ehesan Ul Sharif

IPC: C07H19/23 ,  A61K31/706 ,  A61K45/06 ,  C07H19/207 ,  C07H19/20 ,  C07H19/16 ,  A61K31/7076 ,  A61K31/70 ,  C07F9/6561 ,  C07H19/14 ,  A61K31/7064 ,  A61K31/7052 ,  C07H19/04

Abstract: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.