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1.发明申请4-(METHYLAMINOPHENOXY)PYRDIN-3-YL-BENZAMIDE DERIVATIVES FOR TREATING CANCER 审中-公开用于治疗癌症的4-（甲基氨基苯氧基）PYRDIN-3-YL-苯甲酰胺衍生物公开(公告)号：US20150105432A1
公开(公告)日：2015-04-16
申请号：US14574102
申请日：2014-12-17
发明人： Takashi NAKAGAWA , Makoto SAKAMOTO , Kazuya YAMAGUCHI , Yuki TERAUCHI , Masamichi SHIRAKURA , Yasuo HARADA , Yutaka KOJIMA , Takumi SUMIDA
IPC分类号： C07D213/75
CPC分类号： C07D213/75 , C07D213/76
摘要： The present invention provides a novel compound having an excellent antitumor effect, stability and metabolic stability. The compound of the present invention is represented by the following general formula (1) wherein R1 represents a halogen atom, an aryl group, an aryloxy group or a lower alkyl group optionally substituted with one or more halogen atoms; R2 represents a hydrogen atom, a halogen atom, a lower alkyl group or it lower alkoxy group; and; m represents an integer of 1 to 3; provided that when m represents 2 or 3, R1s are the same or different.
摘要翻译： 本发明提供具有优异的抗肿瘤效果，稳定性和代谢稳定性的新型化合物。 本发明化合物由以下通式（1）表示，其中R 1表示卤素原子，芳基，芳氧基或任选被一个或多个卤素原子取代的低级烷基; R2表示氢原子，卤素原子，低级烷基或低级烷氧基; 和; m表示1〜3的整数， 条件是当m表示2或3时，R 1相同或不同。
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公开(公告)号：US20230139808A1
公开(公告)日：2023-05-04
申请号：US18148672
申请日：2022-12-30
发明人： Takashi NAKAGAWA , Makoto SAKAMOTO , Kazuya YAMAGUCHI , Yuki TERAUCHI , Masamichi SHIRAKURA , Yasuo HARADA , Yutaka KOJIMA , Takumi SUMIDA
IPC分类号： C07D213/75 , C07D213/76
摘要： The present invention provides a novel compound having an excellent antitumor effect stability and metabolic stability. The compound of the present invention is represented by the following general formula (1) wherein R1 represents a halogen atom, an aryl group, an aryloxy group or a lower alkyl group optionally substituted with one or more halogen atoms; R2 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; and; m represents an integer of 1 to 3; provided that when m represents 2 or 3, R1s are the same or different.
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公开(公告)号：US20210017134A1
公开(公告)日：2021-01-21
申请号：US17039731
申请日：2020-09-30
发明人： Takashi NAKAGAWA , Makoto SAKAMOTO , Kazuya YAMAGUCHI , Yuki TERAUCHI , Masamichi SHIRAKURA , Yasuo HARADA , Yutaka KOJIMA , Takumi SUMIDA
IPC分类号： C07D213/75 , C07D213/76
摘要： The present invention provides a novel compound having an excellent antitumor effect, stability and metabolic stability. The compound of the present invention is represented by the following general formula (1) wherein R1 represents a halogen atom, an aryl group, an aryloxy group or a lower alkyl group optionally substituted with one or more halogen atoms; R2 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; and; m represents an integer of 1 to 3; provided that when m represents 2 or 3, R1s are the same or different.
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公开(公告)号：US20200031773A1
公开(公告)日：2020-01-30
申请号：US16440924
申请日：2019-06-13
发明人： Takashi NAKAGAWA , Makoto SAKAMOTO , Kazuya YAMAGUCHI , Yuki TERAUCHI , Masamichi SHIRAKURA , Yasuo HARADA , Yutaka KOJIMA , Takumi SUMIDA
IPC分类号： C07D213/75 , C07D213/76
摘要： The present invention provides a novel compound having an excellent antitumor effect, stability and metabolic stability. The compound of the present invention is represented by the following general formula (1) wherein R1 represents a halogen atom, an aryl group, an aryloxy group or a lower alkyl group optionally substituted with one or more halogen atoms; R2 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; and; m represents an integer of 1 to 3; provided that when m represents 2 or 3, R1s are the same or different.
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公开(公告)号：US20230062476A1
公开(公告)日：2023-03-02
申请号：US17797551
申请日：2021-03-01
发明人： Yasuo HARADA , Akitsu HOTTA , Huaigeng XU , Naoshi SUGIMOTO , Koji ETO
摘要： A production method for a genetically modified megakaryocyte, the method including a step of introducing a CRISPR-associated (Cas) family protein and guide RNA (gRNA) into a megakaryocyte to modify a subject gene, in which the Cas family protein and the gRNA to be introduced into the megakaryocyte in the step form a complex beforehand. This production method is useful as a technique for producing a genetically modified megakaryocyte and a modified platelet.
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公开(公告)号：US20180265471A1
公开(公告)日：2018-09-20
申请号：US15969690
申请日：2018-05-02
发明人： Takashi NAKAGAWA , Makoto SAKAMOTO , Kazuya YAMAGUCHI , Yuki TERAUCHI , Masamichi SHIRAKURA , Yasuo HARADA , Yutaka KOJIMA , Takumi SUMIDA
IPC分类号： C07D213/75 , C07D213/76
CPC分类号： C07D213/75 , C07D213/76
摘要： The present invention provides a novel compound having an excellent antitumor effect, stability and metabolic stability. The compound of the present invention is represented by the following general formula (1) wherein R1 represents a halogen atom, an aryl group, an aryloxy group or a lower alkyl group optionally substituted with one or more halogen atoms; R2 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; and; m represents an integer of 1 to 3; provided that when m represents 2 or 3, R1s are the same or different.
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公开(公告)号：US20170298023A1
公开(公告)日：2017-10-19
申请号：US15362561
申请日：2016-11-28
发明人： Takashi NAKAGAWA , Makoto SAKAMOTO , Kazuya YAMAGUCHI , Yuki TERAUCHI , Masamichi SHIRAKURA , Yasuo HARADA , Yutaka KOJIMA , Takumi SUMIDA
IPC分类号： C07D213/75 , C07D213/76
CPC分类号： C07D213/75 , C07D213/76
摘要： The present invention provides a novel compound having an excellent antitumor effect, stability and metabolic stability. The compound of the present invention is represented by the following formula (1) wherein R1 represents a halogen atom, an aryl group, an aryloxy group or a lower alkyl group optionally substituted with one or more halogen atoms; R2 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; and; m represents an integer of 1 to 3; provided that when m represents 2 or 3, R1s are the same or different.
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