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1.发明公开公开(公告)号：US20240156746A1
公开(公告)日：2024-05-16
申请号：US18544302
申请日：2023-12-18
Applicant: Finncure Oy
Inventor： Erik Johan Niemelä
IPC: A61K9/51 , A61K9/00 , A61K9/16 , A61K9/50 , A61K31/56 , A61K31/7105 , A61K31/711 , A61K33/30 , A61K39/145 , A61K39/215 , A61K47/62 , A61K47/69 , C07K14/08 , C07K17/00 , C07K17/02 , C07K17/14
CPC classification number: A61K9/5184 , A61K9/007 , A61K9/167 , A61K9/5078 , A61K9/5089 , A61K9/51 , A61K9/5192 , A61K31/56 , A61K31/7105 , A61K31/711 , A61K33/30 , A61K39/145 , A61K39/215 , A61K47/62 , A61K47/6929 , C07K14/08 , C07K17/00 , C07K17/02 , C07K17/14 , A61K2039/544
Abstract: According to some embodiments, a method of providing treatment of a host comprises binding a carrier to cell structures of cells of the host to reduce a likelihood of an agent binding to said cell structures to at least partially inhibits the agent from binding to said cell structures, wherein the carrier comprises a core and a surface functionalized on the core, wherein the functionalized surface bind to target areas of cell structures of the host's cells, and wherein the carrier is to be used as targeted treatment for one or more disease, infections or allergic reactions caused by a disease-causing agent or source.
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公开(公告)号：US11845807B2
公开(公告)日：2023-12-19
申请号：US17521425
申请日：2021-11-08
Applicant: Cornell Research Foundation, Inc.
Inventor： Hazel H. Szeto , Kesheng Zhao , Hugh Robertson , Alex V. Birk
IPC: C07K17/00 , C07K5/107 , C07K5/11 , C12N15/87 , A61K47/64 , A61K31/713 , A61K38/47 , C12N9/38 , C12N9/96 , C12N15/113 , C07K5/08
CPC classification number: C07K17/00 , A61K31/713 , A61K38/47 , A61K47/64 , A61K47/645 , C07K5/08 , C07K5/1016 , C07K5/1019 , C12N9/2471 , C12N9/96 , C12N15/113 , C12N15/87 , C12Y302/01023 , C12N2310/3513 , C12N2320/32
Abstract: The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide.
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公开(公告)号：US20180215796A1
公开(公告)日：2018-08-02
申请号：US15876610
申请日：2018-01-22
Applicant: Kaneka Corporation
Inventor： Masakatsu Nishihachijyo , Yoshiyuki Nakano , Fuminori Konoike , Masayuki Takano , Shinichi Yoshida , Kazunobu Minakuchi
CPC classification number: C07K14/31 , B01D15/3809 , B01J20/286 , B01J20/3274 , C07K1/22 , C07K17/00 , C07K2319/30
Abstract: A protein includes an amino acid sequence derived from a sequence selected from the group consisting of SEQ ID NOs: 1 to 5. The amino acid sequence includes a substitution of a hydrophobic amino acid residue, an acidic amino acid residue, or a polar uncharged amino acid residue with a basic amino acid residue, and the protein has a reduced antibody-binding capacity in an acidic pH range, as compared to a protein including the amino acid sequence without the substitution.
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4.发明申请公开(公告)号：US20180215795A1
公开(公告)日：2018-08-02
申请号：US15876597
申请日：2018-01-22
Applicant: Kaneka Corporation
Inventor： Masakatsu Nishihachijyo , Yoshiyuki Nakano , Fuminori Konoike , Masayuki Takano , Shinichi Yoshida , Kazunobu Minakuchi
CPC classification number: C07K14/31 , C07K1/22 , C07K14/195 , C07K17/00 , C07K19/00 , C07K2319/30 , C12N5/10 , C12N15/09
Abstract: A protein includes an amino acid sequence derived from a sequence selected from the group consisting of SEQ ID NOs: 1 to 5. The amino acid sequence includes a substitution of a hydrophobic amino acid residue in an Fc binding site with a different hydrophobic amino acid residue or a polar uncharged amino acid residue, and the protein has a reduced antibody-binding capacity in an acidic pH range, as compared to a protein including the amino acid sequence without the substitution.
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公开(公告)号：US20180186838A1
公开(公告)日：2018-07-05
申请号：US15539709
申请日：2014-12-26
Applicant: BGI SHENZHEN
CPC classification number: C07K14/003 , A61K38/02 , A61K38/10 , C07K1/00 , C07K7/08 , C07K17/00 , C12N5/10 , C12N15/63
Abstract: Provided is a new conotoxin peptide κ-CPTx-btl01. The conotoxin peptide κ-CPTx-btl01 has derivative polypeptide that has an amino acid sequence indicated by SEQ ID NO:1, or has derivative polypeptide that has an amino acid sequence indicated by SEQ ID NO:1 and that is formed after substitution, addition or deletion of one or more amino acids are performed and has original functions. Also provided is polynucleotide for coding the peptide, comprising a constructed body of the polynucleotide, an expression carrier and transformed cells. A peptide preparation method and uses in the treatment of diseases related to a calcium ion channel.
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Patent Agency Ranking
公开(公告)号：US20180094035A1
公开(公告)日：2018-04-05
申请号：US15839352
申请日：2017-12-12
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Michael SUPER , Jeffrey Charles WAY , Donald E. INGBER
IPC: C07K14/47 , G01N33/569 , C07K17/00 , C07K16/44
CPC classification number: C07K14/4726 , C07K16/44 , C07K17/00 , C07K2317/53 , C07K2317/66 , C07K2319/30 , G01N33/56961 , G01N2333/40
Abstract: The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis.
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7.发明申请公开(公告)号：US20170333521A1
公开(公告)日：2017-11-23
申请号：US15418571
申请日：2017-01-27
Applicant: Sophiris Bio Inc.
Inventor： Allison J. HULME , Hash AHMED , Mark EMBERTON
IPC: A61K38/17 , C07K14/195 , C07K17/00 , C07K1/00 , A61K38/00
CPC classification number: A61K38/17 , A61K9/0009 , A61K9/0019 , A61K38/00 , A61K38/164 , A61K41/0047 , C07K1/00 , C07K14/195 , C07K17/00 , C07K2319/30 , C07K2319/33
Abstract: This application relates to methods of targeted focal treatment for localized prostate cancer.
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8.发明申请公开(公告)号：US20170210777A1
公开(公告)日：2017-07-27
申请号：US15469660
申请日：2017-03-27
Applicant: FUJIFILM Corporation
Inventor： Koichi MINAMI
CPC classification number: C07K1/22 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/001 , C07K17/00 , C07K2319/00
Abstract: Provided are an antibody-binding polypeptide as set forth in any one of SEQ ID NOS: 1 to 18 and an adsorption material of an antibody or antibody derivative in which the antibody-binding polypeptide is immobilized on a water-insoluble carrier. These antibody-binding polypeptide and adsorption material have excellent antibody binding properties and selectivity, and also excellent alkali resistance and temporal stability.
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公开(公告)号：US09663559B2
公开(公告)日：2017-05-30
申请号：US15063471
申请日：2016-03-07
Applicant: GE Healthcare BioProcess R&D AB
Inventor： Martin Hall , Sture Larsson , Andreas Muranyi , Gustav Rodrigo , Jinyu Zou , Per-Mikael Aberg
CPC classification number: B01J20/24 , B01D15/3809 , B01J20/28019 , B01J20/285 , B01J20/286 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/3274 , B01J20/3293 , B01J2220/52 , B01J2220/54 , C07K1/22 , C07K14/31 , C07K16/00 , C07K17/00 , C07K17/10 , C07K2317/55
Abstract: The present invention relates to a chromatography ligand, which comprises Domain C from Staphylococcus protein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIP) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. The invention also relates to a process of using the ligand in isolation of antibodies, and to a purification protocol which may include washing steps and/or regeneration with alkali.
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公开(公告)号：US20160341727A1
公开(公告)日：2016-11-24
申请号：US14994042
申请日：2016-01-12
Applicant: ISIS INNOVATION LIMITED
Inventor： Graham Ogg , Li-Chieh Huang , Aamir Aslam
IPC: G01N33/569 , G01N33/543
CPC classification number: G01N33/56977 , C07K17/00 , C12N15/1055 , G01N33/54313 , G01N33/56972 , G01N2333/7051 , G01N2333/70539
Abstract: A method to identify a peptide and/or its encoding DNA, wherein the peptide binds to a T-cell receptor and/or an NK-cell receptor and/or an NKT-cell receptor, the method comprising: providing a carrier to which is attached a peptide and its encoding DNA; providing an MHC and/or an MHC-like molecule; and exposing the peptide to a T-cell receptor and/or an NK-cell receptor and/or an NKT-cell receptor in the presence of the MHC or MHC-like molecule.
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