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公开(公告)号：US12102659B2
公开(公告)日：2024-10-01
申请号：US18079604
申请日：2022-12-12
发明人： Hazel H. Szeto , Peter S. Rabinovitch , Dao-Fu Dai
CPC分类号： A61K38/07 , A61K9/0019 , A61K45/06 , A61P9/00 , C07K5/0817 , C07K5/1016 , C07K5/1019 , A61K38/07 , A61K2300/00
摘要： The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof.
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公开(公告)号：US12076363B2
公开(公告)日：2024-09-03
申请号：US17482699
申请日：2021-09-23
发明人： Shirin Kapur , Alana Lerner , Christopher J. Kirk , Eric Lowe , Tracey Lin
IPC分类号： A61K38/07 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/4545 , A61K31/4745 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K38/04 , A61K38/06 , A61K38/08 , A61K45/06 , C07K5/083 , C07K5/107
CPC分类号： A61K38/07 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/4545 , A61K31/4745 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K38/04 , A61K38/06 , A61K38/08 , A61K45/06 , C07K5/081 , C07K5/1016 , A61K38/06 , A61K2300/00 , A61K38/07 , A61K2300/00 , A61K31/4745 , A61K2300/00 , A61K31/5025 , A61K2300/00 , A61K31/426 , A61K2300/00 , A61K31/5377 , A61K2300/00 , A61K31/506 , A61K2300/00 , A61K31/4545 , A61K2300/00 , A61K31/427 , A61K2300/00 , A61K31/454 , A61K2300/00
摘要： This disclosure provides methods of treating a cancer in a patient using a peptide epoxyketone proteasome inhibitor in combination with a PIM kinase inhibitor.
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公开(公告)号：US20240252863A1
公开(公告)日：2024-08-01
申请号：US18633704
申请日：2024-04-12
发明人： Thomas Multer
IPC分类号： A62C37/11 , A61K38/00 , A62C3/00 , A62C35/60 , A62C35/62 , A62C35/68 , A62C37/14 , C07C51/41 , C07C53/18 , C07D301/00 , C07D301/03 , C07D303/36 , C07K1/107 , C07K1/30 , C07K5/087 , C07K5/103 , C07K5/107
CPC分类号： A62C37/11 , A62C3/004 , A62C35/68 , C07C51/412 , C07C53/18 , C07D301/00 , C07D301/03 , C07D303/36 , C07K1/1075 , C07K1/306 , C07K5/0812 , C07K5/1008 , C07K5/1016 , A61K38/00 , A62C35/60 , A62C35/62 , A62C37/14
摘要： A dry fire protection sprinkler in which, when a ratio of a pressure P1 of a pressurized fluid in a flexible tube to a pressure P3 of the fluid in a fluid supply line is less than a predetermined ratio of at least 3 to 1, a differential pressure controller sends a signal to a control valve to open, in order to allow the pressurized fluid in a pressurized fluid source at a pressure of P2 to enter the flexible tube, and, when the ratio of the pressure P1 of the pressurized fluid in the flexible tube to the pressure P3 of the fluid in the fluid supply line equals the predetermined ratio, the differential pressure controller sends a signal to the control valve to close.
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公开(公告)号：US11998781B2
公开(公告)日：2024-06-04
申请号：US18340095
申请日：2023-06-23
发明人： Thomas Multer
IPC分类号： A62C37/11 , A62C3/00 , A62C35/60 , A62C35/62 , A62C35/68 , A62C37/14 , C07C51/41 , C07C53/18 , C07D301/00 , C07D301/03 , C07D303/36 , C07K1/107 , C07K1/30 , C07K5/087 , C07K5/103 , C07K5/107 , A61K38/00
CPC分类号： A62C37/11 , A62C3/004 , A62C35/68 , C07C51/412 , C07C53/18 , C07D301/00 , C07D301/03 , C07D303/36 , C07K1/1075 , C07K1/306 , C07K5/0812 , C07K5/1008 , C07K5/1016 , A61K38/00 , A62C35/60 , A62C35/62 , A62C37/14
摘要： A dry fire protection sprinkler in which, when a ratio of a pressure P1 of a pressurized fluid in a flexible tube to a pressure P3 of the fluid in a fluid supply line is less than a predetermined ratio of at least 3 to 1, a differential pressure controller sends a signal to a control valve to open, in order to allow the pressurized fluid in a pressurized fluid source at a pressure of P2 to enter the flexible tube, and, when the ratio of the pressure P1 of the pressurized fluid in the flexible tube to the pressure P3 of the fluid in the fluid supply line equals the predetermined ratio, the differential pressure controller sends a signal to the control valve to close.
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公开(公告)号：US20240150399A1
公开(公告)日：2024-05-09
申请号：US18412769
申请日：2024-01-15
申请人： MICROSINTESIS INC.
IPC分类号： C07K7/06 , A23L33/18 , A23L33/195 , A61L15/46 , A61L27/54 , A61L29/16 , A61L31/16 , C07K5/107 , C07K5/113
CPC分类号： C07K7/06 , A23L33/18 , A23L33/195 , A61L15/46 , A61L27/54 , A61L29/16 , A61L31/16 , C07K5/1016 , C07K5/1021 , A61K38/00
摘要： Provided are peptides that are derived from probiotic bacteria that have use for preventing and/or treating non-enteric infections in a subject. The peptides derived from the probiotic bacteria also have use for reducing the virulence of non-enteric infections in a subject. Also provided are compositions of the peptides formulated as or within food products, beverages, nutritional supplements, medicaments and the like.
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公开(公告)号：US20240092832A1
公开(公告)日：2024-03-21
申请号：US18120648
申请日：2023-03-13
发明人： Guozhu Zheng
CPC分类号： C07K5/1016 , A61P13/12 , A61K38/00
摘要： Disclosed are deuterated analogs of SBT-20 and elamipretide (MTP-131). The compounds are useful for the treatment and prevention of ischemia-reperfusion injury (e.g., cardiac ischemia-reperfusion injury) or myocardial infarction.
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公开(公告)号：US20230398172A1
公开(公告)日：2023-12-14
申请号：US18115847
申请日：2023-08-30
申请人： Cornell University
发明人： Hazel H. SZETO , Diane FELSEN
CPC分类号： A61K38/07 , C07K5/1019 , C07K5/1016 , A61K38/06 , A61K38/00
摘要： The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a radiocontrast dye. The methods include administering to the subject an effective amount of an aromatic-cationic peptide to a subject in need thereof.
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公开(公告)号：US20230381264A1
公开(公告)日：2023-11-30
申请号：US18448650
申请日：2023-08-11
发明人： Liping Liu , Shibo Tang , Xiaoling Liang
CPC分类号： A61K38/06 , C07K5/0817 , A61K38/07 , C07K5/1016 , A61P27/02 , A61K45/06 , A61P27/12
摘要： The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
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公开(公告)号：US20230293624A1
公开(公告)日：2023-09-21
申请号：US17668744
申请日：2022-02-10
发明人： Hazel H. Szeto , Peter W. Schiller , Kesheng Zhao
CPC分类号： A61K38/07 , A61K38/03 , C07K5/1008 , C07K5/1016 , C07K5/1019 , C07K5/1024
摘要： The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2 a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.
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公开(公告)号：US11628198B2
公开(公告)日：2023-04-18
申请号：US16851382
申请日：2020-04-17
申请人： Cornell University
发明人： Hazel H. Szeto , Diane Felsen
摘要： The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a radiocontrast dye. The methods include administering to the subject an effective amount of an aromatic-cationic peptide to a subject in need thereof.
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