知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

526 records (took 0.025 seconds)

    TETRAPEPTIDES, COMPOSITIONS COMPRISING THEM, AND THEIR COSMETIC USE
    4.
    发明公开
    TETRAPEPTIDES, COMPOSITIONS COMPRISING THEM, AND THEIR COSMETIC USE 审中-公开

    公开(公告)号：US20230398049A1

    公开(公告)日：2023-12-14

    申请号：US18035840

    申请日：2021-11-17

    Applicant: Sederma

    Inventor： Philippe Mondon ,  Olivier Peschard ,  Richard Leroux

    IPC: A61K8/64 ,  C07K5/103 ,  C07K5/11 ,  C07K5/113 ,  A61Q19/08 ,  A61Q19/00

    CPC classification number: A61K8/64 ,  C07K5/101 ,  C07K5/1019 ,  C07K5/1021 ,  A61Q19/08 ,  A61Q19/00

    Abstract: They have the general Formula X-(Xaa)nLE(Xaa)m-Z wherein Xaa is selected from L, K, E and D, either n=2 and m=0, or n=1 and m=1, at the N-terminal end X being selected from H, —CO—R1, —SO2-R1 or a biotinoyl group, at the C-terminal end Z being selected from OH, OR1, NH2, NHR1 or NR1R2, and R1 and R2 being selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy, saccharide and aryloxy, said group having from 1 to 24 carbon atoms. Preferred peptide sequences are X-LKLE-Z and X-ELED-Z. These tetrapeptides stimulate the synthesis of molecules constituting the ECM, in particular collagen 1 and 4, hyaluronic acid and fibronectin, and can be used for a cosmetic treatment, in particular anti-aging, anti-wrinkle and fine lines, to improve the skin mechanical properties, to increase skin density and volume, hydration, and/or to fight against stretch marks, and skin sagging.

    METHODS FOR THE TREATMENT OF MITOCHONDRIAL DISEASE
    5.
    发明公开
    METHODS FOR THE TREATMENT OF MITOCHONDRIAL DISEASE 审中-公开

    公开(公告)号：US20230279051A1

    公开(公告)日：2023-09-07

    申请号：US17963697

    申请日：2022-10-11

    Applicant: Stealth BioTherapeutics Inc.

    Inventor： D. Travis Wilson

    IPC: C07K5/11 ,  A61K38/07 ,  C07K5/107

    CPC classification number: C07K5/1019 ,  A61K38/07 ,  C07K5/1016 ,  A61K45/06

    Abstract: The disclosure provides methods of preventing, ameliorating or treating disruption of mitochondrial function and symptoms thereof. The methods provide administering aromatic-cationic peptides in effective amounts to prevent, treat or ameliorate the disruption of mitochondrial oxidative phosphorylation in a cell such as that found in a subject suffering from, or predisposed to a mitochondrial disease or disorder. In some embodiments, the methods comprise administering to a subject suffering from, or at risk for a mitochondrial disease or disorder, an effective amount of an aromatic-cationic peptide to subjects in need thereof.

    METHODS FOR REDUCING OXIDATIVE DAMAGE
    6.
    发明公开
    METHODS FOR REDUCING OXIDATIVE DAMAGE 审中-公开

    公开(公告)号：US20230149501A1

    公开(公告)日：2023-05-18

    申请号：US17493551

    申请日：2021-10-04

    Applicant: Cornell Research Foundation, Inc.

    Inventor： Hazel H. Szeto

    IPC: A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  C07K5/11

    CPC classification number: A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  C07K5/1019

    Abstract: The invention provides a method for reducing oxidative damage in a mammal, a removed organ, or a cell in need thereof. The method comprises administering an effective amount of an aromatic cationic peptide. The aromatic cationic peptide has (a) at least one net positive charge; (b) a minimum of three amino acids; (c) a maximum of about twenty amino acids, (d) a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3 pm is the largest number that is less than or equal to r+1; (e) a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 3a or 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1; and (f) at least one tyrosine or tryptophan amino acid.

Patent Agency Ranking