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公开(公告)号：US20210170073A1
公开(公告)日：2021-06-10
申请号：US16865734
申请日：2020-05-04
申请人： 3-D Matrix, Ltd.
发明人： Eun Seok Gil , Marc Rioult , Keiji Nagano , Karl Patrick Gilbert , Toshiro Kiyofuji , Yuya Hasegawa
摘要： Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided. Particular peptides include those comprising, or consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods of sterilizing the self-assembling peptides, and scaffolds comprising the peptides are also provided.
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公开(公告)号：US10961274B2
公开(公告)日：2021-03-30
申请号：US16062801
申请日：2016-12-15
申请人： 3-D Matrix, Ltd.
发明人： Eun Seok Gil , Marc Rioult , Keiji Nagano , Karl Patrick Gilbert , Toshiro Kiyofuji , Yuya Hasegawa
摘要： Self-assembling peptides comprising non-ionic polar amino acids for anti-adhesion are provided herein. Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided to prevent adhesion or to provide anti-adhesion properties. Particular peptides include those consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods and kits are also provided.
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公开(公告)号：US12006085B2
公开(公告)日：2024-06-11
申请号：US17832612
申请日：2022-06-04
申请人： 3-D Matrix, Ltd.
发明人： Masahiro Nohara , Yuya Hasegawa
IPC分类号： C07K1/34 , B65B3/00 , B65B55/04 , B65B55/12 , B65B63/00 , C07K1/36 , C07K7/08 , A61K38/00 , C07K5/103 , C07K5/11
CPC分类号： B65B55/12 , B65B3/003 , B65B55/04 , B65B63/00 , C07K1/34 , C07K1/36 , C07K7/08 , A61K38/00 , C07K5/101 , C07K5/1019
摘要： The enclosed disclosure describes, among other things, a method including the steps of a first deaerating step in which a mixture comprising peptides is deaerated by lowering the pressure, filtering the mixture through a sterilizing filter; and a second deaerating step, in which the filtrate is deaerated by vibration and lowering the pressure.
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公开(公告)号：US20220258900A9
公开(公告)日：2022-08-18
申请号：US16948353
申请日：2020-09-15
申请人： 3-D Matrix, Ltd.
发明人： Masahiro Nohara , Yuya Hasegawa
摘要： The enclosed disclosure describes, among other things, a method including the steps of a first deaerating step in which a mixture comprising peptides is deaerated by lowering the pressure, filtering the mixture through a sterilizing filter; and a second deaerating step, in which the filtrate is deaerated by vibration and lowering the pressure.
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公开(公告)号：US20210024236A1
公开(公告)日：2021-01-28
申请号：US16948353
申请日：2020-09-15
申请人： 3-D Matrix, Ltd.
发明人： Masahiro Nohara , Yuya Hasegawa
摘要： The enclosed disclosure describes, among other things, a method including the steps of a first deaerating step in which a mixture comprising peptides is deaerated by lowering the pressure, filtering the mixture through a sterilizing filter; and a second deaerating step, in which the filtrate is deaerated by vibration and lowering the pressure.
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公开(公告)号：US10793307B2
公开(公告)日：2020-10-06
申请号：US14413156
申请日：2013-07-03
申请人： 3-D MATRIX, LTD.
发明人： Masahiro Nohara , Yuya Hasegawa
IPC分类号： C07K1/34 , C07K1/36 , C07K7/08 , B65B55/12 , B65B3/00 , B65B55/04 , B65B63/00 , C07K5/103 , C07K5/11 , A61K38/00
摘要： The enclosed disclosure describes, among other things, a method including the steps of a first deaerating step in which a mixture comprising peptides is deaerated by lowering the pressure, filtering the mixture through a sterilizing filter; and a second deaerating step, in which the filtrate is deaerated by vibration and lowering the pressure.
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公开(公告)号：US10682441B2
公开(公告)日：2020-06-16
申请号：US15534715
申请日：2015-12-11
申请人： 3-D Matrix, Ltd.
发明人： Eun Seok Gil , Marc Rioult , Keiji Nagano , Karl Partick Gilbert , Toshiro Kiyofuji , Yuya Hasegawa
摘要： Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided. Particular peptides include those comprising or consisting essentially of serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods of sterilizing the self-assembling peptides, and scaffolds comprising the peptides are also provided.
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公开(公告)号：US11497833B2
公开(公告)日：2022-11-15
申请号：US16865734
申请日：2020-05-04
申请人： 3-D Matrix, Ltd.
发明人： Eun Seok Gil , Marika Rioult , Keiji Nagano , Karl Patrick Gilbert , Toshiro Kiyofuji , Yuya Hasegawa
摘要： Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided. Particular peptides include those comprising, or consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods of sterilizing the self-assembling peptides, and scaffolds comprising the peptides are also provided.
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公开(公告)号：US20220324601A1
公开(公告)日：2022-10-13
申请号：US17832612
申请日：2022-06-04
申请人： 3-D Matrix, Ltd.
发明人： Masahiro Nohara , Yuya Hasegawa
摘要： The enclosed disclosure describes, among other things, a method including the steps of a first deaerating step in which a mixture comprising peptides is deaerated by lowering the pressure, filtering the mixture through a sterilizing filter; and a second deaerating step, in which the filtrate is deaerated by vibration and lowering the pressure.
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公开(公告)号：US20170360990A1
公开(公告)日：2017-12-21
申请号：US15534715
申请日：2015-12-11
发明人： Eun Seok Gil , Marc Rioult , Keiji Nagano , Karl Patrick Gilbert , Toshiro Kiyofuji , Yuya Hasegawa
CPC分类号： A61L27/52 , A61L27/227 , A61L27/54 , A61L2300/25 , C07K7/08 , C07K14/001
摘要： Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided. Particular peptides include those comprising or consisting essentially of serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods of sterilizing the self-assembling peptides, and scaffolds comprising the peptides are also provided.
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