公开(公告)号：US20180205202A1

公开(公告)日：2018-07-19

申请号：US15874498

申请日：2018-01-18

Applicant: ISIS Innovation Limited ,  ISIS Innovation Limited

Inventor： Paul Burn ,  Ifor Samuel ,  Justin Lawrence ,  Jonathan Markham

IPC: H01S5/36 ,  H01S5/12 ,  H01S5/04

CPC classification number: H01S5/36 ,  H01S5/041 ,  H01S5/12 ,  H01S5/1231

Abstract: A distributed feedback laser having a conjugated dendrimer as the active lasing component, and a method for patterning conjugated dendrimers.

公开(公告)号：US11369279B2

公开(公告)日：2022-06-28

申请号：US14999198

申请日：2016-04-08

Applicant: Isis Innovation Limited

Inventor： Eleanor Berry ,  Thomas Okell ,  Peter Jezzard

IPC: A61B5/026 ,  A61B5/00 ,  G01R33/563 ,  G01R33/483 ,  G01R33/565

Abstract: Systems and methods are provided to incorporate an off-resonance correction into the pulse labeling train of PCASL/VEPCASL. In one or more aspects, the systems and methods are based on a method for generating an encoding scheme for any number and arrangement of blood vessels. The off-resonance correction can be incorporated into the generation of optimized encodings to acquire arterial spin labeling (ASL) data, such as PCASL and VEPCASL data.

公开(公告)号：US20220025419A1

公开(公告)日：2022-01-27

申请号：US17190128

申请日：2021-03-02

Applicant: ISIS INNOVATION LIMITED ,  GlycoVaxyn AG

Inventor： Benjamin G. DAVIS ,  Balakumar VIJAYAKRISHNAN ,  Feng LIU ,  Michael WACKER ,  Amirreza FARIDMOAYER ,  Michael Thomas KOWARIK

IPC: C12P19/18 ,  C07H11/04 ,  C12P19/28 ,  C07K9/00

Abstract: A process for the production of a glycoconjugate by N-glycosylation of a protein or peptide comprising the sequence D/E-X-N-X-S/T (SEQ ID NO:1), wherein each X is the same or different and is any natural amino acid other than proline, wherein the process comprises reacting the protein or peptide with a polyisoprenyl pyrophosphate of formula (I), or a salt thereof, in the presence of PglB: to produce the glycoconjugate comprising the protein or peptide having a saccharide [S1] linked to the asparagine in the sequence D/E-X-N-X-S/T (SEQ ID NO:1). Polyisoprenylpyrophosphates used as substrates in the biocatalytic process are also provided, as well as certain glycoconjugates.

公开(公告)号：US11213797B2

公开(公告)日：2022-01-04

申请号：US14649394

申请日：2013-12-06

Applicant: Isis Innovation Limited

Inventor： John Hagan Pryce Bayley ,  Gabriel Villar ,  Alexander D. Graham

IPC: B29C64/112 ,  A61K9/127 ,  B01J13/04 ,  B01L3/02 ,  C09B67/02 ,  C09B57/00 ,  B29C69/00 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/02 ,  B33Y80/00 ,  B29K105/00 ,  B29L31/00

Abstract: The invention relates to an apparatus for producing a droplet assembly, which apparatus comprises a droplet generator. A process for producing a droplet assembly, using an apparatus comprising a droplet generator is also described. The invention also relates to droplet assemblies comprising a plurality of droplets. Various uses of the droplet assemblies are also described.

公开(公告)号：US10575771B2

公开(公告)日：2020-03-03

申请号：US14364750

申请日：2012-12-13

Applicant: Isis Innovation Limited

Inventor： Rajarshi Banerjee ,  Stefan Piechnik ,  Matthew Robson ,  Belen Rial ,  Elizabeth Tunnicliffe ,  Stefan Neubauer

IPC: A61B5/00 ,  A61B5/055 ,  G01R33/48 ,  G01R33/50 ,  G01R33/46 ,  G01R33/54

Abstract: Described herein are systems and methods for performing multi-parametric diagnosis for liver disease. Systems and methods as described herein can include positioning a subject-in association with a medical imaging device and using the medical imaging device to measure the subject's liver for extracellular fluid and iron content. Systems and methods as described herein can further include determining whether iron overload may be indicated or present from the measurement for iron content, and if indicated, correcting the measurement for extra cellular fluid. Systems and methods as described herein can further include measuring the liver for hepatic lipid content (HLC). Systems and methods as described herein can determine the presence or absence of liver disease from measurements obtained from a subject. In certain embodiments, the medical imaging device is a magnetic resonance (MR) scanner. In certain embodiments, the liver is measured for iron overload.

公开(公告)号：US10162031B2

公开(公告)日：2018-12-25

申请号：US14775864

申请日：2014-03-14

Applicant: Isis Innovation Limited

Inventor： Elizabeth Tunnicliffee ,  Matthew Robson ,  Rajarshi Banerjee

IPC: G01R33/50 ,  A61B5/00 ,  A61B5/055 ,  A61B5/145 ,  G01R33/44 ,  G06T7/00

Abstract: The present disclosure provides systems and methods which may assist in evaluating liver fibrosis/inflammation in the presence of elevated iron using magnetic resonance relaxometry. In a non-limiting embodiment, the systems and methods include: obtaining a measurement of relaxometry data of a subject's liver for extracellular fluid, preferably using a magnetic resonance imaging (MRI) device; determining an iron content for the liver; simulating a measurement of the subject's liver for extracellular fluid for the determined iron content; comparing the measurement of the subject's liver for extracellular fluid to the simulated measurement of the subject's liver for extracellular fluid; and determining from said comparison a value of extracellular fluid in the subject's liver based on a normal iron content for the liver. The simulation can include multi-compartment modeling of various fractions of extracellular fluid in the liver and the impact of iron content in the liver on both the intra- and extracellular relaxation times.

公开(公告)号：US20180169048A1

公开(公告)日：2018-06-21

申请号：US15127717

申请日：2015-03-17

Applicant: ISIS Innovation Limited

Inventor： David Smith ,  Fredrik Jerneren ,  Helga Refsum

IPC: A61K31/202 ,  A61K31/519 ,  A61K31/714 ,  A61K31/232 ,  A61K31/4415 ,  A61K9/00 ,  A61K31/205 ,  A61K31/14 ,  A61P25/28

CPC classification number: A61K31/202 ,  A61K9/0053 ,  A61K31/14 ,  A61K31/205 ,  A61K31/232 ,  A61K31/4415 ,  A61K31/519 ,  A61K31/714 ,  A61P25/28 ,  A61K2300/00

Abstract: The present invention provides a combined therapy comprising the use of one or more omega-3 fatty acids and one or more B vitamins and for treating cognitive impairment, such cognitive impairment disorders include, especially but not exclusively, Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD). The present invention also provides a treatment: for individuals suffering from cognitive impairment disorders that occur as a result of brain or cerebral atrophy, the invention includes inter alma methods of treating and/or reducing progression of brain atrophy and pharmaceutical compositions and nutritional supplements therefor.

公开(公告)号：US09984775B2

公开(公告)日：2018-05-29

申请号：US14772984

申请日：2014-03-06

Applicant: Isis Innovation Limited

Inventor： Yiannis Ventikos ,  Nicholas Hawker

IPC: G10K15/04 ,  G21B3/00 ,  F15B21/12

CPC classification number: G21B3/006 ,  F15B21/12 ,  G10K15/043

Abstract: A method of producing a localized concentration of energy includes: creating a shockwave propagating through a non-gaseous medium so as to be incident upon a boundary between the non-gaseous medium and a gaseous medium formed by at least one hole in a barrier separating the non-gaseous medium from a gaseous medium. This forms a transverse jet on the other side of the hole which is incident upon a target surface comprising a depression which is spaced from the barrier in the gaseous medium. An apparatus for producing a localized concentration of energy is also described.

公开(公告)号：US09984774B2

公开(公告)日：2018-05-29

申请号：US14772941

申请日：2014-03-06

Applicant: Isis Innovation Limited

Inventor： Yiannis Ventikos ,  Nicholas Hawker ,  Matthew Betney

IPC: G10K15/04 ,  G21B3/00 ,  F15B21/12

CPC classification number: G21B3/006 ,  F15B21/12 ,  G10K15/043

Abstract: A method of producing a localized concentration of energy includes: creating at least one shockwave propagating through a non-gaseous medium so as first to be incident upon a focusing pocket of fluid within the medium. The focusing pocket of fluid is positioned relative to a differently sized target pocket of gas within the medium, and is arranged to shield the target pocket of gas from the initial shockwave, such that the incidence of the shockwave on the focusing pocket of fluid concentrates the intensity of a shockwave subsequently incident upon the target pocket of gas. An apparatus for producing a localized concentration of energy is also described.

公开(公告)号：US09957563B2

公开(公告)日：2018-05-01

申请号：US14548975

申请日：2014-11-20

Applicant: Isis Innovation Limited

Inventor： Emma Link ,  Sarah Parish ,  Rory Collins ,  Mark Lathrop

IPC: C12Q1/68

CPC classification number: C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172

Abstract: This invention relates to a method of determining the susceptibility of an individual to statin-induced myopathy, comprising detecting the presence or absence of one or more polymorphisms in the SLCO1B1 gene in a biological sample from an individual, whereby the presence of one or more polymorphisms indicates that the individual has altered susceptibility to statin-induced myopathy.