公开(公告)号：US20240325485A1

公开(公告)日：2024-10-03

申请号：US18610110

申请日：2024-03-19

申请人： JIANGNAN UNIVERSITY

发明人： Ruijie LIU ,  Yiwen GUO ,  Zhu ZHU ,  Ming CHANG

IPC分类号： A61K36/82 ,  A61K31/232

CPC分类号： A61K36/82 ,  A61K31/232

摘要： A combination containing enriched hill shaddock oil (HSO) is provided to prevent or alleviate inflammatory bowel disease (IBD). The composition combination includes 30% to 50 wt % of branched chain fatty acid (BCFA) glycerides and 50% to 70 wt % of the oil-tea seed oil. The composition combination has significant anti-inflammatory effect on intestinal epithelial cells. Secretion of inflammatory factors is regulated to reduce the production of products of cellular inflammatory reactions. By adding HSO, intestinal tissue damage is alleviated, repair of the intestinal barrier is promoted, and the remission period of IBD is prolonged. The BCFA glycerides are formed by combining diacylglycerol with triacylglycerol and facilitate digestion, absorption, and metabolism, allowing relief of fat digestion and absorption disorders in patients suffering from IBD. In addition, the composition combination has enriched mono-unsaturated fatty acids, enabling the composition combination to be stable, facilitating regulation of human physiological functions and improving metabolism.

公开(公告)号：US12005040B2

公开(公告)日：2024-06-11

申请号：US17330760

申请日：2021-05-26

申请人： CORNELL UNIVERSITY

发明人： Yong Lak Joo ,  Nathaniel S. Hansen ,  Daehwan Cho

IPC分类号： H01B1/20 ,  A61K31/202 ,  A61K31/232 ,  B22F1/054 ,  B22F1/07 ,  B22F9/30 ,  B82Y30/00 ,  C04B35/622 ,  D01D5/00 ,  D01F1/10 ,  D01F9/08 ,  D04H1/4234 ,  D04H1/728 ,  H01B1/02 ,  H01B1/08

CPC分类号： A61K31/202 ,  A61K31/232 ,  B22F1/0547 ,  B22F1/07 ,  B22F9/30 ,  B82Y30/00 ,  C04B35/62227 ,  C04B35/62231 ,  C04B35/62236 ,  C04B35/6224 ,  C04B35/6225 ,  C04B35/62254 ,  C04B35/62259 ,  D01D5/0007 ,  D01D5/0015 ,  D01F1/10 ,  D01F9/08 ,  D04H1/4234 ,  D04H1/728 ,  H01B1/02 ,  H01B1/026 ,  H01B1/08 ,  C04B2235/40 ,  C04B2235/441 ,  C04B2235/443 ,  C04B2235/444 ,  C04B2235/449 ,  C04B2235/526 ,  C04B2235/5264 ,  C04B2235/5296

摘要： Provided herein are nanofibers and processes of preparing nanofibers. In some instances, the nanofibers are metal and/or ceramic nanofibers. In some embodiments, the nanofibers are high quality, high performance nanofibers, highly coherent nanofibers, highly continuous nanofibers, or the like. In some embodiments, the nanofibers have increased coherence, increased length, few voids and/or defects, and/or other advantageous characteristics. In some instances, the nanofibers are produced by electrospinning a fluid stock having a high loading of nanofiber precursor in the fluid stock. In some instances, the fluid stock comprises well mixed and/or uniformly distributed precursor in the fluid stock. In some instances, the fluid stock is converted into a nanofiber comprising few voids, few defects, long or tunable length, and the like.

公开(公告)号：US11925688B2

公开(公告)日：2024-03-12

申请号：US17449685

申请日：2021-10-01

申请人： Thetis Pharmaceuticals LLC

发明人： Frank C. Sciavolino ,  Gary Mathias ,  Michael C. Van Zandt ,  Gunnar Erik Jagdmann, Jr. ,  Jessica J. Dworak

IPC分类号： A61K47/54 ,  A61K31/202 ,  A61K31/232 ,  A61K38/03 ,  A61K45/06 ,  A61K47/62 ,  A61P1/00 ,  A61P1/04 ,  A61P1/06 ,  A61P1/12 ,  A61P29/00 ,  C07C59/42 ,  C07C229/26 ,  C07C237/12 ,  C07C237/22

CPC分类号： A61K47/541 ,  A61K31/202 ,  A61K31/232 ,  A61K38/03 ,  A61K45/06 ,  A61K47/62 ,  A61P1/00 ,  A61P1/04 ,  A61P1/06 ,  A61P1/12 ,  A61P29/00 ,  C07C59/42 ,  C07C229/26 ,  C07C237/12 ,  C07C237/22 ,  A61K2800/00

摘要： The present invention relates to compounds of Formulas I-IV, which are salts of special lipid mediators of inflammation, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both.

公开(公告)号：US20240033241A1

公开(公告)日：2024-02-01

申请号：US18484831

申请日：2023-10-11

申请人： NIPPON SUISAN KAISHA, LTD.

发明人： Jiro TAKEO ,  Hiroyuki KAWAHARA

IPC分类号： A61K31/202 ,  A61K9/00 ,  A61K47/06 ,  A61K31/683 ,  A61P17/00 ,  A61P17/04 ,  A61K31/232 ,  A61K31/685 ,  A61K31/7032

CPC分类号： A61K31/202 ,  A61K9/0014 ,  A61K47/06 ,  A61K31/683 ,  A61P17/00 ,  A61P17/04 ,  A61K31/232 ,  A61K31/685 ,  A61K31/7032

摘要： [Problem] To provide a composition for external skin use that has anti-inflammatory and antiallergic activity and is very safe. [Solution] A composition for external skin use for inflammatory diseases contains dihomo-gamma-linolenic acid (DGLA) as the active ingredient thereof. It is preferable for the DGLA to be present as a glyceride, a phospholipid, or an alkyl ester. The amount of DGLA contained in the composition for external use is 0.1-50 wt %.

公开(公告)号：US20240016803A1

公开(公告)日：2024-01-18

申请号：US18151382

申请日：2023-01-06

申请人： Amarin Pharmaceuticals Ireland Limited

发明人： George Grandolfi

IPC分类号： A61K31/505 ,  A61K31/232 ,  A61K31/202 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P9/00

CPC分类号： A61K31/505 ,  A61K31/232 ,  A61K31/202 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P9/00

摘要： The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and a statin and to methods of using the same to treat or prevent cardiovascular-related diseases.

公开(公告)号：US20230416186A1

公开(公告)日：2023-12-28

申请号：US18334880

申请日：2023-06-14

申请人： Commonwealth Scientific and Industrial Research Organisation ,  Grains Research and Development Corporation ,  Nuseed Nutritional Australia Pty Ltd

发明人： James Robertson Petrie ,  Surinder Pal Singh ,  Pushkar Shrestha ,  Jason Timothy McAllister ,  Robert Charles de Feyter ,  Malcolm David Devine ,  Xue-Rong Zhou

IPC分类号： C07C69/587 ,  C11B3/10 ,  C11B3/02 ,  A23D9/00 ,  A61K31/20 ,  A61K31/201 ,  A61K31/202 ,  C11B7/00 ,  C11C3/00 ,  A01H5/00 ,  A61K31/232 ,  C12N15/52 ,  C12N15/82 ,  A61K36/185 ,  A61K36/31 ,  C11B3/04 ,  C11B1/10 ,  A61K31/23 ,  C11B3/12

CPC分类号： C07C69/587 ,  A61K2236/00 ,  C11B3/02 ,  A23D9/00 ,  A61K31/20 ,  A61K31/201 ,  A61K31/202 ,  C11B7/0075 ,  C11C3/003 ,  A01H5/00 ,  A61K31/232 ,  C12N15/52 ,  C12N15/8247 ,  A61K36/185 ,  A61K36/31 ,  C11B3/04 ,  C11B1/10 ,  A61K31/23 ,  C11B3/12 ,  C11B3/10

摘要： The present invention relates to lipid comprising docosapentaenoic acid and/or docosahexaenoic acid wherein the docosapentaenoic acid and/or docosahexaenoic acid may be preferentially esterified at the sn-2 position of triacylglycerol, and processes for producing and using the lipid.

公开(公告)号：US11834621B2

公开(公告)日：2023-12-05

申请号：US17150898

申请日：2021-01-15

申请人： Commonwealth Scientific and Industrial Research Organisation ,  Grains Research and Development Corporation ,  Nuseed Nutritional Australia Pty Ltd

发明人： James Robertson Petrie ,  Surinder Pal Singh ,  Robert Charles de Feyter

IPC分类号： C11B1/10 ,  C07C67/02 ,  C11C3/00 ,  C12N9/10 ,  C12N15/82 ,  C07C57/03 ,  C07C57/02 ,  A01H5/10 ,  A01H6/20 ,  A01H1/00 ,  C11B1/00 ,  C11C3/06 ,  A61K36/31 ,  C11C1/00 ,  A23L33/12 ,  C07K14/415 ,  A23K20/158 ,  A61K31/231 ,  A61K31/232

CPC分类号： C11B1/10 ,  A01H1/104 ,  A01H5/10 ,  A01H6/20 ,  A61K36/31 ,  C07C57/02 ,  C07C57/03 ,  C07C67/02 ,  C11B1/00 ,  C11C1/002 ,  C11C3/00 ,  C11C3/003 ,  C11C3/06 ,  C12N9/1025 ,  C12N15/8247 ,  A23K20/158 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/231 ,  A61K31/232 ,  A61K2236/35 ,  C07K14/415

摘要： The present invention relates to extracted plant lipid, comprising fatty acids in an esterified form.

公开(公告)号：US11826336B2

公开(公告)日：2023-11-28

申请号：US17335969

申请日：2021-06-01

申请人： Emory University ,  Children's Healthcare of Atlanta, Inc.

发明人： Claudia R. Morris

IPC分类号： A23L33/12 ,  A61K31/23 ,  A61K31/202 ,  A61K31/122 ,  A61K31/07 ,  A61K31/59 ,  A61K38/46 ,  A61K31/7004 ,  A61K31/473 ,  A61K35/741 ,  A61K33/26 ,  A61K31/661 ,  A61K33/18 ,  A61K33/34 ,  A61K33/32 ,  A61K33/24 ,  A61K31/047 ,  A61K31/385 ,  A61K31/205 ,  A61K31/375 ,  A61K33/30 ,  A61K31/355 ,  A23L33/175 ,  A23L33/15 ,  A61K31/22 ,  A61K33/42 ,  A23L33/00 ,  A61K45/06 ,  A23L33/16 ,  A61K31/19 ,  A61K31/4375 ,  A23L33/155 ,  A61K31/231 ,  A61K9/00 ,  A61K31/232 ,  A61K31/20 ,  A23L33/135 ,  A61K35/00 ,  A61K9/20 ,  A61K9/14 ,  A61K9/48

CPC分类号： A61K31/23 ,  A23L33/12 ,  A23L33/135 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/175 ,  A23L33/40 ,  A61K9/0056 ,  A61K31/047 ,  A61K31/07 ,  A61K31/122 ,  A61K31/19 ,  A61K31/20 ,  A61K31/202 ,  A61K31/205 ,  A61K31/22 ,  A61K31/231 ,  A61K31/232 ,  A61K31/355 ,  A61K31/375 ,  A61K31/385 ,  A61K31/4375 ,  A61K31/473 ,  A61K31/59 ,  A61K31/661 ,  A61K31/7004 ,  A61K33/18 ,  A61K33/24 ,  A61K33/26 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K33/42 ,  A61K35/741 ,  A61K38/46 ,  A61K45/06 ,  A23V2002/00 ,  A61K9/145 ,  A61K9/2013 ,  A61K9/4858 ,  A61K2035/115 ,  A61K31/4375 ,  A61K2300/00 ,  A61K31/047 ,  A61K2300/00 ,  A61K33/18 ,  A61K2300/00 ,  A61K33/26 ,  A61K2300/00 ,  A61K33/32 ,  A61K2300/00 ,  A61K33/34 ,  A61K2300/00 ,  A61K33/42 ,  A61K2300/00 ,  A61K33/24 ,  A61K2300/00 ,  A61K31/7004 ,  A61K2300/00 ,  A61K31/355 ,  A61K2300/00 ,  A61K31/122 ,  A61K2300/00 ,  A61K31/07 ,  A61K2300/00 ,  A61K31/202 ,  A61K2300/00 ,  A61K31/23 ,  A61K2300/00 ,  A61K31/231 ,  A61K2300/00 ,  A61K31/20 ,  A61K2300/00 ,  A61K31/22 ,  A61K2300/00 ,  A61K31/661 ,  A61K2300/00 ,  A61K31/205 ,  A61K2300/00 ,  A61K31/59 ,  A61K2300/00 ,  A61K31/19 ,  A61K2300/00 ,  A61K31/232 ,  A61K2300/00

摘要： This disclosure relates to nutritional formulas and uses for treating or preventing a gastrointestinal condition and/or motor-planning speech and/or coordinator difficulties. In certain embodiments, this disclosure relates to a nutritional formula comprising medium chain fatty acids, or esters thereof (such as and tri-, di-, mono-glycerides, or alkyl esters), unsaturated fatty acids, and a vitamin E and optionally other nutrients. In certain embodiments, any of the compounds or nutrients may be in alternative salt forms.

公开(公告)号：US20230263179A1

公开(公告)日：2023-08-24

申请号：US18172992

申请日：2023-02-22

申请人： Beijing Sanyuan Foods Co., Ltd.

发明人： Lijun CHEN ,  Jingyao Chen ,  Junying Zhao ,  Yan Liu ,  Qian Liu ,  Bin Liu ,  Weicang Qiao

IPC分类号： A23C9/152 ,  A23C9/16 ,  A23C3/02 ,  A61K38/17 ,  A61K38/38 ,  A61K38/40 ,  A61K31/702 ,  A61K31/715 ,  A61K31/7008 ,  A61K31/688 ,  A61K31/7028 ,  A61K31/685 ,  A61K31/683 ,  A61K31/231 ,  A61K31/232 ,  A61K35/20 ,  A61P1/14

CPC分类号： A23C9/1526 ,  A23C9/16 ,  A23C9/1528 ,  A23C3/02 ,  A61K38/1709 ,  A61K38/38 ,  A61K38/40 ,  A61K38/1735 ,  A61K31/702 ,  A61K31/715 ,  A61K31/7008 ,  A61K31/688 ,  A61K31/7028 ,  A61K31/685 ,  A61K31/683 ,  A61K31/231 ,  A61K31/232 ,  A61K35/20 ,  A61P1/14

摘要： An infant formula milk powder is rich in milk fat globule membrane protein, phospholipids, and oligosaccharides. A preparation method includes using raw cow milk as raw material, cleaning and pre-sterilizing raw cow milk, adding MFGM-rich whey protein powder, α-lactalbumin powder, galactooligosaccharides, polyfructoses and other ingredients into the pre-sterilized raw cow milk, and performing pre-sterilization, homogenization, sterilization, concentration, and spray drying. By means of formula adjustment, the contents of biologically active substances having special functional components such as MFGM-protein, lactoferrin, α-lactalbumin, total galactooligosaccharide, total polyfructose, sialic acid, total phospholipid, sphingomyelin, lecithin, phosphatidylserine, phosphatidylethanolamines, phosphatidylinositol, ganglioside, triglyceride and diglyceride in the infant formula milk powder are increased, thereby facilitating the colonization of probiotics in the intestinal microbiota of an infant, especially significantly enriching lactic acid bacteria in an intestinal tract, while reducing unclassified bacterial family and other miscellaneous bacteria.

公开(公告)号：US11603347B2

公开(公告)日：2023-03-14

申请号：US17317179

申请日：2021-05-11

申请人： NIPPON SUISAN KAISHA, LTD.

发明人： Nobushige Doisaki ,  Kazuhiko Hata ,  Shinji Tokiwa ,  Kazunori Matsushima

IPC分类号： C07C69/587 ,  C07C67/03 ,  C07C67/54 ,  C07C67/56 ,  C07C51/47 ,  C07C57/03 ,  C11C3/00 ,  A23D9/02 ,  C11B3/12 ,  A23L33/115 ,  A61K31/20 ,  A61K31/202 ,  A61K31/232 ,  B01D3/14 ,  B01D15/32 ,  C07C51/44 ,  C11B3/16

摘要： A highly unsaturated fatty acid or a highly unsaturated fatty acid ethyl ester that has been produced using as a feedstock oil a fat or oil that contains highly unsaturated fatty acids as constituent fatty acids and which has been reduced in the contents of environmental pollutants, wherein among the dioxins contained, polychlorinated dibenzoparadioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are contained in amounts of less than 0.05 pg-TEQ/g and coplanar PCBs (Co-PCBs) in amounts of less than 0.03 pg-TEQ/g. Also disclosed is a method for producing the highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester by the steps of removing free fatty acids and environmental pollutants by thin-film distillation from a feedstock oil, ethyl esterifying the resulting fat or oil, and refining the same by rectification and column chromatography.