公开(公告)号：US11890308B2

公开(公告)日：2024-02-06

申请号：US18179839

申请日：2023-03-07

申请人： Finch Therapeutics Holdings LLC

发明人： Thomas Julius Borody

IPC分类号： A61K35/74 ,  A61K35/24 ,  A61M3/02 ,  C12N1/20 ,  C12N1/00 ,  A61P1/12 ,  A61M39/00 ,  A61J1/14 ,  A61K35/741 ,  A61K9/48 ,  A61K35/742 ,  A61K35/00 ,  A61M31/00 ,  A61B10/00 ,  A61M39/24 ,  A61M5/142

CPC分类号： A61K35/74 ,  A61J1/1468 ,  A61K9/4891 ,  A61K35/24 ,  A61K35/741 ,  A61K35/742 ,  A61M3/02 ,  A61M3/0204 ,  A61M39/00 ,  A61P1/12 ,  C12N1/00 ,  C12N1/20 ,  A61B10/0038 ,  A61K9/4875 ,  A61K2035/115 ,  A61M5/142 ,  A61M31/00 ,  A61M39/24

摘要： The present disclosure provides compositions, e.g., formulations, used for gastric, gastrointestinal and/or colonic treatments; and methods for making and using them. Methods of the invention are used for the stabilization, amelioration, treatment and/or prevention of constipation, for the treatment of abdominal pain, particularly non-specific abdominal pain, and diarrhea, including diarrhea caused by a drug side effect, a psychological condition, a disease or a condition such as Crohn's Disease, a poison, a toxin or an infection, e.g., a toxin-mediated traveler's diarrhea, or C. difficile or the pseudo-membranous colitis associated with this infection.

公开(公告)号：US11857510B2

公开(公告)日：2024-01-02

申请号：US16617463

申请日：2018-05-31

申请人： NAPO PHARMACEUTICALS, INC.

发明人： Lisa A. Conte ,  Pravin R. Chaturvedi

IPC分类号： A61K31/353 ,  A61P1/12 ,  A61P1/04 ,  A61K9/00 ,  A61K9/28 ,  A61K9/48

CPC分类号： A61K31/353 ,  A61K9/0095 ,  A61K9/28 ,  A61K9/48 ,  A61P1/04 ,  A61P1/12

摘要： Presented herein are methods and compositions for treating congenital diarrheal disorders (CDD). Methods comprise administering to a patient in need thereof, an effective amount of a proanthocyanidin polymer composition from C. lechleri, preferably crofelemer. Administration of the proanthocyanidin polymer composition addresses the secretory diarrhea and symptoms associated therewith caused by the CDD and can improve nutritional status, electrolyte balance, hydration, growth and development of the patient.

公开(公告)号：US11850269B2

公开(公告)日：2023-12-26

申请号：US17207164

申请日：2021-03-19

申请人： Finch Therapeutics Holdings LLC

发明人： Thomas Julius Borody

IPC分类号： A61K35/74 ,  A61K35/741 ,  A61K35/24 ,  C12N1/00 ,  A61P1/12 ,  C12N1/20 ,  A61M39/00 ,  A61J1/14 ,  A61M3/02 ,  A61K9/48 ,  A61K35/742 ,  A61K35/00 ,  A61M31/00 ,  A61B10/00 ,  A61M39/24 ,  A61M5/142

CPC分类号： A61K35/741 ,  A61J1/1468 ,  A61K9/4891 ,  A61K35/24 ,  A61K35/74 ,  A61K35/742 ,  A61M3/02 ,  A61M3/0204 ,  A61M39/00 ,  A61P1/12 ,  C12N1/00 ,  C12N1/20 ,  A61B10/0038 ,  A61K9/4875 ,  A61K2035/115 ,  A61M5/142 ,  A61M31/00 ,  A61M39/24

摘要： The present disclosure provides compositions, e.g., formulations, used for gastric, gastrointestinal and/or colonic treatments or lavage, e.g., orthostatic lavage, e.g., for inducing the purgation (e.g., cleansing) of a gastrointestinal (GI) tract, including a colon; and methods for making and using them. Methods of the invention are used for the stabilization, amelioration, treatment and/or prevention of constipation, for the treatment of abdominal pain, particularly non-specific abdominal pain, and diarrhea, including diarrhea caused by a drug side effect, a psychological condition, a disease or a condition such as Crohn's Disease, a poison, a toxin or an infection, e.g., a toxin-mediated traveler's diarrhea, or C. difficile or the pseudo-membranous colitis associated with this infection.

公开(公告)号：US11752132B2

公开(公告)日：2023-09-12

申请号：US17161811

申请日：2021-01-29

申请人： University of Florida Research Foundation, Incorporated

发明人： Sadasivan Vidyasagar ,  Paul Okunieff ,  Lurong Zhang

IPC分类号： A61K31/405 ,  A61K9/00 ,  A61K31/7004 ,  A61K31/7016 ,  A61K47/18 ,  A61P1/12 ,  A61K47/20 ,  A61K31/197 ,  A61K31/198

CPC分类号： A61K31/405 ,  A61K9/0095 ,  A61K31/197 ,  A61K31/198 ,  A61K31/7004 ,  A61K31/7016 ,  A61K47/183 ,  A61K47/20 ,  A61P1/12 ,  A61K31/197 ,  A61K2300/00 ,  A61K31/405 ,  A61K2300/00 ,  A61K31/7004 ,  A61K2300/00 ,  A61K31/7016 ,  A61K2300/00

摘要： The subject invention provides therapeutic compositions, and uses thereof for the treatment or amelioration of injury to small intestine mucosa. In preferred embodiments, the composition comprises one or more nutrients and/or electrolytes that acquire or retain considerable absorptive capacity.

公开(公告)号：US20230241136A1

公开(公告)日：2023-08-03

申请号：US18060626

申请日：2022-12-01

申请人： BIOGAIA AB

发明人： James Versalovic ,  Bo Mollstam ,  Chunxu Gao ,  Bhanu Priya Ganesh

IPC分类号： A61K35/747 ,  A61K35/744 ,  C12N1/20 ,  A61P15/02 ,  A61P1/12 ,  A61P1/00 ,  A61P29/00 ,  A61P35/00

CPC分类号： A61K35/747 ,  A61K35/744 ,  C12N1/205 ,  A61P15/02 ,  A61P1/12 ,  A61P1/00 ,  A61P29/00 ,  A61P35/00 ,  C12R2001/225

摘要： The invention herein discloses histamine-producing bacterial strains for use in the prophylaxis, inhibition, treatment or reducing a risk of relapse of cancer, including colorectal cancer. The present invention also discloses the use of histamine-producing bacterial strains for manufacturing a medicament for treatment of cancer, including male colorectal cancer.

公开(公告)号：US20230212582A1

公开(公告)日：2023-07-06

申请号：US17996505

申请日：2021-04-23

申请人： Nogra Pharma Limited

发明人： Francesca Viti ,  Giovanni Monteleone ,  Salvatore Demartis ,  Salvatore Bellinvia ,  Marie McNulty

IPC分类号： C12N15/113 ,  G01N33/68 ,  A61P1/12

CPC分类号： C12N15/1136 ,  G01N33/6863 ,  A61P1/12 ,  C12N2310/3341 ,  C12N2310/315 ,  C12N2310/322

摘要： The present disclosure relates to compositions of oligonucleotide (e.g., SMAD7 antisense oligonucleotide diastereomers) and methods of manufacturing, assessing efficacy, and using the compositions.

公开(公告)号：US20230210915A1

公开(公告)日：2023-07-06

申请号：US18179839

申请日：2023-03-07

申请人： Finch Therapeutics Holdings LLC

发明人： Thomas Julius Borody

IPC分类号： A61K35/74 ,  A61K35/24 ,  C12N1/00 ,  A61P1/12 ,  C12N1/20 ,  A61M39/00 ,  A61J1/14 ,  A61M3/02 ,  A61K9/48 ,  A61K35/742

CPC分类号： A61K35/74 ,  A61K35/24 ,  C12N1/00 ,  A61P1/12 ,  C12N1/20 ,  A61M39/00 ,  A61J1/1468 ,  A61M3/02 ,  A61M3/0204 ,  A61K9/4891 ,  A61K35/742 ,  A61K2035/115

摘要： In alternative embodiments, the invention provides compositions, e.g., formulations, used for gastric, gastrointestinal and/or colonic treatments or lavage, e.g., orthostatic lavage, e.g., for inducing the purgation (e.g., cleansing) of a gastrointestinal (GI) tract, including a colon; and methods for making and using them. In alternative embodiments, compositions and methods of the invention are used for the stabilization, amelioration, treatment and/or prevention of constipation, for the treatment of abdominal pain, particularly non-specific abdominal pain, and diarrhea, including diarrhea caused by a drug side effect, a psychological condition, a disease or a condition such as Crohn's Disease, a poison, a toxin or an infection, e.g., a toxin-mediated travelers diarrhea, or C. difficile or the pseudo-membranous colitis associated with this infection. In alternative embodiments, the invention provides pharmaceuticals and products (articles) of manufacture for delivering these compositions and formulations to an individual, e.g., a human or an animal. The invention also provides devices for delivering a fecal material to a patient.

公开(公告)号：US20230190946A1

公开(公告)日：2023-06-22

申请号：US18068657

申请日：2022-12-20

申请人： Zealand Pharma A/S

发明人： Stefan Schunk

IPC分类号： A61K47/64 ,  A61K47/54 ,  A61P1/12 ,  A61P29/00

CPC分类号： A61K47/64 ,  A61K47/545 ,  A61P1/12 ,  A61P29/00

摘要： Compounds of formula (1):




and pharmaceutically acceptable salts and solvates thereof, are described. The compounds are α4β7 antagonists and are useful in the prevention or treatment of inflammatory conditions and/or autoimmune diseases, especially inflammatory bowel disease.

公开(公告)号：US20180133200A1

公开(公告)日：2018-05-17

申请号：US15860852

申请日：2018-01-03

申请人： Array BioPharma, Inc.

发明人： Steven W. Andrews ,  Sean Aronow ,  James F. Blake ,  Barbara J. Brandhuber ,  Adam Cook ,  Julia Haas ,  Yutong Jiang ,  Gabrielle R. Kolakowski ,  Elizabeth A. McFaddin ,  Megan L. McKenney ,  Oren T. McNulty ,  Andrew T. Metcalf ,  David A. Moreno ,  Tony P. Tang ,  Li Ren

IPC分类号： A61K31/444 ,  A61K31/496 ,  A61P35/00 ,  A61P35/02 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/551

CPC分类号： C07D471/04 ,  A61K31/444 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/4995 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  A61P1/12 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  C07D519/00

摘要： Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

公开(公告)号：US09308226B2

公开(公告)日：2016-04-12

申请号：US13813915

申请日：2011-08-04

申请人： Thomas Julius Borody

发明人： Thomas Julius Borody

IPC分类号： A61K35/74 ,  A61M5/142 ,  A61K35/24 ,  C12N1/00 ,  A61K35/00 ,  A61K9/48 ,  A61M31/00

CPC分类号： A61K35/74 ,  A61K9/4875 ,  A61K9/4891 ,  A61K35/24 ,  A61K35/742 ,  A61K2035/115 ,  A61M5/142 ,  A61M31/00 ,  A61P1/12 ,  C12N1/00

摘要： In alternative embodiments, the invention provides compositions, e.g., formulations, used for gastric, gastrointestinal and/or colonic treatments or lavage, e.g., orthostatic lavage, e.g., for inducing the purgation (e.g., cleansing) of a gastrointestinal (GI) tract, including a colon; and methods for making and using them. In alternative embodiments, compositions and methods of the invention are used for the stabilization, amelioration, treatment and/or prevention of constipation, for the treatment of abdominal pain, particularly non-specific abdominal pain, and diarrhea, including diarrhea caused by a drug side effect, a psychological condition, a disease or a condition such as Crohn's Disease, a poison, a toxin or an infection, e.g., a toxin-mediated traveler's diarrhea, or C. difficile or the pseudo-membranous colitis associated with this infection. In alternative embodiments, the invention provides pharmaceuticals and products (articles) of manufacture for delivering these compositions and formulations to an individual, e.g., a human or an animal. The invention also provides devices for delivering a fecal material to a patient.

摘要翻译： 在替代实施方案中，本发明提供用于胃，胃肠和/或结肠治疗或灌洗的组合物，例如制剂，例如直立灌洗，例如用于诱导胃肠道（GI）道的清除（例如，清洁） 包括一个冒号 以及制作和使用它们的方法。 在替代实施方案中，本发明的组合物和方法用于治疗便秘，用于治疗腹痛，特别是非特异性腹痛，以及腹泻，包括由药物侧引起的腹泻的稳定化，改善，治疗和/或预防 效果，心理状况，疾病或诸如克罗恩病，毒素，毒素或感染（例如毒素介导的旅行者腹泻或艰难梭菌或与该感染相关的假性膜性结肠炎）的病症。 在替代实施方案中，本发明提供用于将这些组合物和制剂递送给个体例如人或动物的药物和制品（制品）。 本发明还提供了将粪便材料输送给患者的装置。