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1.发明公开公开(公告)号：US20240264179A1
公开(公告)日：2024-08-08
申请号：US18476528
申请日：2023-09-28
发明人： Lijun CHEN , Minghui ZHANG , Weicang QIAO , Junying ZHAO , Ge JIA , Yan LIU , Yaling WANG , Qian LIU , Baoyu YANG
CPC分类号： G01N33/92 , G01N33/6851 , G01N2800/38
摘要： The present invention provides a marker set for evaluating the development of an infant's communication ability. The marker set is composed of the following fatty acids: C18:3n6, C18:2n6t, C20:3n3, C18:3n3, C18:2n6c, C20:4n6, C20:3n6, C22:6n3, and C20:5n3. The present invention further provides a method for evaluating the development of an infant's communication ability using the marker set. The present invention achieves the evaluation on the development of an infant's communication ability by extracting and detecting the contents of particular fatty acids in a breast milk or dairy product sample fed to an infant, and the development level of the infant among the peers can be inferred based on the evaluation result, so as to give suggestions relevant to diet and nutrition for the mother timely. The method is low in cost, simple and effective, and suitable for large-scale evaluation.
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公开(公告)号：US20230404094A1
公开(公告)日：2023-12-21
申请号：US18335657
申请日：2023-06-15
发明人： Lijun CHEN , Tiemin Jiang , Xiaohong Song , Jiantao Li , Junying Zhao , Bin Liu , Weicang Qiao , Yanpin Liu
IPC分类号： A23C9/127 , A23C9/13 , A61K35/747 , A61K35/20 , A61K38/47
CPC分类号： A23C9/1275 , A23C9/1307 , A61K35/747 , A61K35/20 , A61K38/47 , C12Y302/01108 , A23V2400/249 , A23V2400/169 , A23V2400/113
摘要： Raw materials of a fermented milk include partially degreased raw milk, 4-10% w/w of saccharide based on the mass of the raw milk, 0.06-0.15% w/w of lactase based on the mass of the raw milk, 0.03-0.18% w/w of a stabilizer based on the mass of the raw milk, and 20-50 dcu of fermenting bacteria added per 100 kg of the raw milk; and the fermenting bacteria is one or more selected from the group consisting of Lactobacillus paracasei, Lactobacillus plantarum, Lactobacillus acidophilus, Bifidobacterium lactis and Streptococcus thermophilus, and preferably one or more selected from the group consisting of Lactobacillus plantarum with a preservation number of CGMCC No. 19748, Lactobacillus acidophilus with a preservation number of CGMCC No. 1084 and Streptococcus thermophilus. According to the fermented milk and a preparation method thereof, the prepared fermented milk has a more stable state during the shelf life.
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公开(公告)号：US20240345098A1
公开(公告)日：2024-10-17
申请号：US18476234
申请日：2023-09-27
发明人： Lijun CHEN , Qian LIU , Yan LIU , Junying ZHAO , Bin LIU , Yan LIU , Weicang QIAO , Minghui ZHANG , Yaling WANG , Xiaofei FAN , Ziqi LI
CPC分类号： G01N33/6848 , G01N30/06
摘要： The present invention relates to a method for multidimensional evaluation of the similarity of a sample to breast milk, wherein the method is performed in the following steps: (1) establishing a local breast milk phospholipid database; (2) collecting and pretreating a sample to be evaluated; (3) determining the contents of characteristic phospholipid subclasses, the contents of characteristic phospholipid molecules in the sample to be evaluated, and obtaining a microstructural image of milk fat globules in the sample by confocal laser scanning microscopy; (4) calculating the score G for the sample to be evaluated. The present invention evaluates the similarity of samples to breast milk based on phospholipids in three aspects: the composition of characteristic phospholipid subclasses, the composition of characteristic phospholipid molecules, and the morphological similarity evaluation, so that the scheme can better evaluate the simulation quality of infant formulas and their raw and auxiliary materials to breast milk based on phospholipids.
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公开(公告)号：US20230263179A1
公开(公告)日：2023-08-24
申请号：US18172992
申请日：2023-02-22
发明人： Lijun CHEN , Jingyao Chen , Junying Zhao , Yan Liu , Qian Liu , Bin Liu , Weicang Qiao
IPC分类号： A23C9/152 , A23C9/16 , A23C3/02 , A61K38/17 , A61K38/38 , A61K38/40 , A61K31/702 , A61K31/715 , A61K31/7008 , A61K31/688 , A61K31/7028 , A61K31/685 , A61K31/683 , A61K31/231 , A61K31/232 , A61K35/20 , A61P1/14
CPC分类号： A23C9/1526 , A23C9/16 , A23C9/1528 , A23C3/02 , A61K38/1709 , A61K38/38 , A61K38/40 , A61K38/1735 , A61K31/702 , A61K31/715 , A61K31/7008 , A61K31/688 , A61K31/7028 , A61K31/685 , A61K31/683 , A61K31/231 , A61K31/232 , A61K35/20 , A61P1/14
摘要： An infant formula milk powder is rich in milk fat globule membrane protein, phospholipids, and oligosaccharides. A preparation method includes using raw cow milk as raw material, cleaning and pre-sterilizing raw cow milk, adding MFGM-rich whey protein powder, α-lactalbumin powder, galactooligosaccharides, polyfructoses and other ingredients into the pre-sterilized raw cow milk, and performing pre-sterilization, homogenization, sterilization, concentration, and spray drying. By means of formula adjustment, the contents of biologically active substances having special functional components such as MFGM-protein, lactoferrin, α-lactalbumin, total galactooligosaccharide, total polyfructose, sialic acid, total phospholipid, sphingomyelin, lecithin, phosphatidylserine, phosphatidylethanolamines, phosphatidylinositol, ganglioside, triglyceride and diglyceride in the infant formula milk powder are increased, thereby facilitating the colonization of probiotics in the intestinal microbiota of an infant, especially significantly enriching lactic acid bacteria in an intestinal tract, while reducing unclassified bacterial family and other miscellaneous bacteria.
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5.发明公开公开(公告)号：US20230203206A1
公开(公告)日：2023-06-29
申请号：US18176611
申请日：2023-03-01
发明人： Lijun Chen , Baoyu Yang , Minghui Zhang , Weicang Qiao , Junying Zhao , Jingyao Chen , Yanpin Liu , Jufeng Hu
IPC分类号： C08B37/00 , A23L33/125 , B01D61/14 , B01D61/02 , B01D61/58 , B01D15/20 , B01D69/02 , B01D69/04 , B01D71/02 , B01D61/42 , A23L3/44
CPC分类号： C08B37/006 , A23L3/44 , A23L33/125 , B01D15/206 , B01D61/025 , B01D61/029 , B01D61/58 , B01D61/146 , B01D61/149 , B01D61/0271 , B01D61/422 , B01D61/1471 , B01D69/02 , B01D69/04 , B01D71/02 , B01D2311/06 , B01D2311/08 , B01D2325/20 , B01D2325/02833 , B01D2325/02834
摘要： The present application relates to the technical field of further processing of dairy products, and in particular to a preparation method of milk oligosaccharides, and milk oligosaccharide powder and food prepared thereby. The preparation method comprises the steps of: performing ultrafiltration of whey liquid for at least three times, subjecting the ultrafiltration permeate to nanofiltration concentration for several times, then subjecting the nanofiltration retentate to chromatographic separation and purification, collecting chromatographic collection liquid containing sialyllactose while removing the fraction containing lactose, subjecting the collection to desalination and drying to obtain oligosaccharide powder. The milk oligosaccharides prepared by the present method and the food product containing the same comprise basically bovine milk oligosaccharides, which are light yellow or white in color, light in flavor, uniform in size, and have good thermal stability and solubility. The milk oligosaccharides mainly comprise 3′-sialyllactose and 6′-sialyllactose.
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6.发明公开公开(公告)号：US20230165264A1
公开(公告)日：2023-06-01
申请号：US18156191
申请日：2023-01-18
发明人： Lijun CHEN , Junying ZHAO , Bin LIU , Jingying DONG , Yanpin LIU , Weicang QIAO
IPC分类号： A23C9/158 , A23C9/16 , A23C9/152 , A23C9/156 , A23C3/02 , A23C1/04 , A23L33/135 , A23L33/155 , A23L33/16 , A23L33/19 , A23L33/00
CPC分类号： A23C9/158 , A23C9/16 , A23C9/1522 , A23C9/156 , A23C3/02 , A23C1/04 , A23L33/135 , A23L33/155 , A23L33/16 , A23L33/19 , A23L33/40 , A23Y2220/39 , A23Y2220/73 , A23Y2220/03 , A23Y2300/55 , A23Y2300/21 , A23Y2300/25
摘要： A maternal milk powder and a preparation method thereof. Every 100 g of the maternal milk powder comprises: (0.1-10)×108 CFU of probiotics, 1-10 g of FOS; wherein, probiotics comprise Lactobacillus helveticus, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium longum, Bifidobacterium animalis, and Bifidobacterium bifidum with a CFU ratio of 20-40:20-40:1-10:10-20:10-20:1-10. The maternal milk powder can effectively inhibit the proliferation of harmful bacteria in the intestinal tract of pregnant women, promote the health of intestinal microecology, improve immunity, relieve postpartum depression, etc. by adding six kinds of safe, stable and efficient probiotics and FOS.
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7.发明申请公开(公告)号：US20230080697A1
公开(公告)日：2023-03-16
申请号：US17871549
申请日：2022-07-22
发明人： Lijun CHEN , Tao XU , Jingyao CHEN , Weicang QIAO , Junying ZHAO
摘要： The present disclosure relates to a method for detecting the contents of whey protein and casein, and/or the ratio thereof in milk powder by liquid chromatography-mass spectrometry. According to the method of the present disclosure, the characteristic peptide segments of whey protein and casein are selected and used for correction, and thus the accuracy and stability of detection of peptide segments by mass spectrometry using external standards are improved; in addition, the method of the present disclosure has the following advantages: easy to pretreat samples, low cost, a wide range of applicability, enable to perform quantitative detection of whey protein at one time, not affected by protein denaturation in the production process, no need to synthesize isotope internal standard, and avoiding influence of ionization efficiency and matrix in mass spectrometry detection by means of their own multiple characteristic peptide segment ratios.
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公开(公告)号：US20230050528A1
公开(公告)日：2023-02-16
申请号：US17788549
申请日：2020-06-12
发明人： Lijun CHEN , Lu LIU , Chunmei YIN , Bin LIU , Weiming ZHOU
IPC分类号： A23L33/135 , C12N1/20 , A23C9/123
摘要： Provided are a breast milk-derived Lactobacillus plantarum and use thereof. The breast milk-derived Lactobacillus plantarum, which was screened from healthy breast milk, is classified and named as Lactobacillus plantarum and has an accession number of CGMCC NO.19748. It has strong adhesion, has an inhibitory effect on 8 commonly known pathogenic bacteria, and is susceptible to 8 antibiotics, and also has strong acid resistance and bile salt resistance.
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公开(公告)号：US20230210924A1
公开(公告)日：2023-07-06
申请号：US18175330
申请日：2023-02-27
发明人： Lijun Chen , Yanpin Liu , Jiantao Li , Junying Zhao , Bin Liu , Lu Liu , Weicang Qiao , Weiming Zhou
IPC分类号： A61K35/747 , A61K35/744 , A61K35/745 , A61K9/00 , A61K47/46 , A61P1/10 , A23C9/123 , A23C9/13
CPC分类号： A61K35/747 , A61K35/744 , A61K35/745 , A61K9/0056 , A61K47/46 , A61P1/10 , A23C9/1234 , A23C9/1307 , A23Y2220/37 , A23Y2240/75 , A23Y2220/15 , A23Y2220/03 , A23Y2220/67 , A23Y2220/63 , A23Y2300/29 , A23Y2300/49 , A23Y2300/55
摘要： Disclosed are a yoghurt for regulating intestinal tract, preparation method therefor, and use thereof, where the yogurt is prepared from raw materials comprising the following parts by weight: 90-97 parts of raw milk, Lactobacillus gasseri of (0.7-5)×108 CFU/100 g raw milk, Streptococcus thermophilus of (0.1-9)×1010 CFU/100 g raw milk, Lactobacillus bulgaricus of (0.1-9)×1010 CFU/100 g raw milk, Lactobacillus acidophilus of (0.5-7)×108 CFU/100 g raw milk, Lactobacillus plantarum of (0.5-7)×108 CFU/100 g raw milk, Lactobacillus paracasei of (0.1-9)×107 CFU/100 g raw milk, and other probiotics, and prebiotics such as inulin. The yogurt may regulate the balance of intestinal flora and prevent constipation and gestational diabetes in overweight and/or obese pregnant women during the gestation period.
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