公开(公告)号：US20240317719A1

公开(公告)日：2024-09-26

申请号：US18397454

申请日：2023-12-27

申请人： Ardelyx, Inc.

发明人： Dean DRAGOLI ,  Irina DOTSENKO ,  Jason LEWIS

IPC分类号： C07D403/14 ,  A61K47/55 ,  A61P1/00 ,  A61P1/10 ,  A61P3/12 ,  A61P9/04 ,  A61P9/12 ,  A61P29/00 ,  C07D241/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D487/08

CPC分类号： C07D403/14 ,  A61K47/55 ,  A61P1/00 ,  A61P1/10 ,  A61P3/12 ,  A61P9/04 ,  A61P9/12 ,  A61P29/00 ,  C07D241/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D487/08

摘要： The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders.

公开(公告)号：US20240285634A1

公开(公告)日：2024-08-29

申请号：US18568477

申请日：2022-06-09

申请人： ONQUALITY PHARMACEUTICALS CHINA LTD.

发明人： Wenxi LI ,  Shilan LIU ,  Zhaoyu WU ,  Shiyi ZHANG

IPC分类号： A61K31/519 ,  A61K45/06 ,  A61P1/10

CPC分类号： A61K31/519 ,  A61K45/06 ,  A61P1/10

摘要： A compound and method may treat chemotherapy-associated gastrointestinal side effects. A compound of formula (I) or a pharmaceutically acceptable salt thereof in the preparation of a medicament:




may be used for preventing, alleviating, and/or treating gastrointestinal side effects associated with chemotherapy in a subject. A method may use such a compound to treat chemotherapy-associated gastrointestinal side effects.

公开(公告)号：US11969447B2

公开(公告)日：2024-04-30

申请号：US17204245

申请日：2021-03-17

申请人： GLAC BIOTECH CO., LTD.

发明人： Hsieh-Hsun Ho ,  Ching-Wei Chen ,  Yi-Wei Kuo ,  Yu-Fen Huang ,  Cheng-Chi Lin

IPC分类号： A61K36/82 ,  A23L33/105 ,  A23L33/135 ,  A61K9/00 ,  A61K35/745 ,  A61K35/747 ,  A61K36/185 ,  A61K36/48 ,  A61K36/736 ,  A61P1/10 ,  A61K35/00

CPC分类号： A61K35/747 ,  A23L33/105 ,  A23L33/135 ,  A61K9/0053 ,  A61K35/745 ,  A61K36/185 ,  A61K36/48 ,  A61K36/736 ,  A61P1/10 ,  A23V2002/00 ,  A23V2400/113 ,  A23V2400/181 ,  A23V2400/515 ,  A23V2400/531 ,  A61K2035/115

摘要： A composition for promoting defecation includes a cell culture of at least one lactic acid bacterial strain which is substantially free of cells. The least one lactic acid bacterial strain is selected from the group consisting of Lactobacillus salivarius subsp. salicinius AP-32, Bifidobacterium animalis subsp. lactis CP-9, and Lactobacillus acidophilus TYCA06, which are respectively deposited at the Bioresource Collection and Research Center (BCRC) under accession numbers BCRC 910437, BCRC 910645 and BCRC 910813. Also disclosed is a method for promoting defecation, including administering to a subject in need thereof an effective amount of the composition.

公开(公告)号：US20230374071A1

公开(公告)日：2023-11-23

申请号：US18248452

申请日：2021-10-08

申请人： Dignify Therapeutics, LLC

发明人： Daniel Joseph Ricca

IPC分类号： C07K7/06 ,  A61P1/10 ,  A61P13/00

CPC分类号： C07K7/06 ,  A61P1/10 ,  A61P13/00

摘要： Synthetic neurokinin A peptide analogs are provided as therapeutic compounds for inducing voluntary “on-demand” voiding of urine and feces in mammals who cannot void without external invasion of the bladder and bowel or those who void involuntarily (i.e., those having urinary and/or fecal incontinence). This control over when and where individuals void offers a drastic improvement in quality of life.

公开(公告)号：US20230210924A1

公开(公告)日：2023-07-06

申请号：US18175330

申请日：2023-02-27

申请人： Beijing Sanyuan Foods Co., Ltd.

发明人： Lijun Chen ,  Yanpin Liu ,  Jiantao Li ,  Junying Zhao ,  Bin Liu ,  Lu Liu ,  Weicang Qiao ,  Weiming Zhou

IPC分类号： A61K35/747 ,  A61K35/744 ,  A61K35/745 ,  A61K9/00 ,  A61K47/46 ,  A61P1/10 ,  A23C9/123 ,  A23C9/13

CPC分类号： A61K35/747 ,  A61K35/744 ,  A61K35/745 ,  A61K9/0056 ,  A61K47/46 ,  A61P1/10 ,  A23C9/1234 ,  A23C9/1307 ,  A23Y2220/37 ,  A23Y2240/75 ,  A23Y2220/15 ,  A23Y2220/03 ,  A23Y2220/67 ,  A23Y2220/63 ,  A23Y2300/29 ,  A23Y2300/49 ,  A23Y2300/55

摘要： Disclosed are a yoghurt for regulating intestinal tract, preparation method therefor, and use thereof, where the yogurt is prepared from raw materials comprising the following parts by weight: 90-97 parts of raw milk, Lactobacillus gasseri of (0.7-5)×108 CFU/100 g raw milk, Streptococcus thermophilus of (0.1-9)×1010 CFU/100 g raw milk, Lactobacillus bulgaricus of (0.1-9)×1010 CFU/100 g raw milk, Lactobacillus acidophilus of (0.5-7)×108 CFU/100 g raw milk, Lactobacillus plantarum of (0.5-7)×108 CFU/100 g raw milk, Lactobacillus paracasei of (0.1-9)×107 CFU/100 g raw milk, and other probiotics, and prebiotics such as inulin. The yogurt may regulate the balance of intestinal flora and prevent constipation and gestational diabetes in overweight and/or obese pregnant women during the gestation period.

公开(公告)号：US11643409B2

公开(公告)日：2023-05-09

申请号：US17887325

申请日：2022-08-12

申请人： Renexxion, LLC

发明人： Pascal Jean Druzgala ,  Jien Heh Tien

IPC分类号： C07D453/02 ,  A61K9/00 ,  A61P1/10 ,  A61P1/04 ,  A61K31/439

CPC分类号： C07D453/02 ,  A61K9/0029 ,  A61K9/0053 ,  A61K31/439 ,  A61P1/04 ,  A61P1/10 ,  C07B2200/13 ,  A61K31/439 ,  C07D453/02 ,  C07B2200/13 ,  C07D453/02 ,  C07B2200/13 ,  A61K31/439

摘要： Provided herein is a bulk composition comprising the trihydrate form of (3S, 4R, 3′R)-6-[4-(4-amino-5-chloro-2-methoxy-benzoylamino)-3-methoxy-piperidin-1-yl]-hexanoic acid 1-azabicyclo[2.2.2]oct-3′-yl ester di-hydrochloride salt. Provided are also pharmaceutical compositions and dosage forms comprising the trihydrate form, and methods and uses for treating a gastrointestinal disorder in a subject with the trihydrate form. In some embodiments, the gastrointestinal disorder is gastroesophageal reflux disease (GERD), dyspepsia (such as functional dyspepsia or functional motility disorder), gastroparesis, paralytic ileus, post-operative ileus, emesis, nausea, heartburn, intestinal pseudo-obstruction, irritable bowel syndrome (IBS), constipation, enteral feeding intolerance (EFI), or esophagitis. In some embodiments, the gastrointestinal disorder is post-operative ileus, chronic grass sickness, constipation, megacolon, gastritis, gastrointestinal stasis, or abomasal emptying defect.

公开(公告)号：US20180148476A1

公开(公告)日：2018-05-31

申请号：US15570838

申请日：2016-04-29

申请人： Ironwood Pharmaceuticals, Inc.

发明人： Mark G. Currie ,  Robert Solinga ,  Christopher Leitheiser

IPC分类号： C07K7/08 ,  A61K45/06 ,  A61K38/12 ,  A61K38/10 ,  A61P1/10 ,  A61K9/00 ,  A61P35/00

CPC分类号： C07K7/08 ,  A61K9/0031 ,  A61K9/0053 ,  A61K38/00 ,  A61K38/10 ,  A61K38/12 ,  A61K45/06 ,  A61P1/10 ,  A61P35/00

摘要： The present invention provides peptides and compositions that are useful for the treatment of gastrointestinal disorders or for colon cleansing. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms.

公开(公告)号：US20180002370A1

公开(公告)日：2018-01-04

申请号：US15604527

申请日：2017-05-24

申请人： Enterin Laboratories, Inc.

发明人： Michael Zasloff

IPC分类号： C07J41/00 ,  A61K31/575

CPC分类号： C07J41/0005 ,  A61K31/575 ,  A61K45/06 ,  A61P1/10 ,  A61P25/24 ,  A61P25/28

摘要： This invention relates to methods of stimulating the activity of the human and animal enteric nervous system. The method comprises orally administering an aminoserol, such as squalamine, a naturally occurring aminosterol isolated from Squalus acanthias, or derivatives thereof, to a subject in need.

公开(公告)号：US20240199697A1

公开(公告)日：2024-06-20

申请号：US18424114

申请日：2024-01-26

申请人： Ironwood Pharmaceuticals, Inc.

发明人： Mark G. Currie ,  Robert Solinga ,  Christopher Leitheiser

IPC分类号： C07K7/08 ,  A61K9/00 ,  A61K38/00 ,  A61K38/10 ,  A61K38/12 ,  A61K45/06 ,  A61P1/10 ,  A61P35/00

CPC分类号： C07K7/08 ,  A61K9/0031 ,  A61K9/0053 ,  A61K38/10 ,  A61K38/12 ,  A61K45/06 ,  A61P1/10 ,  A61P35/00 ,  A61K38/00

摘要： The present invention provides peptides and compositions that are useful for the treatment of gastrointestinal disorders or for colon cleansing. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms.

公开(公告)号：US11970483B2

公开(公告)日：2024-04-30

申请号：US17280633

申请日：2019-09-27

申请人： Takeda Pharmaceutical Company Limited

发明人： Shinobu Sasaki ,  Yasutomi Asano ,  Kazuaki Takami ,  Masaki Seto ,  Haruhi Ando

IPC分类号： C07D405/14 ,  A61P1/10 ,  C07D407/12 ,  C07D407/14 ,  C07D413/14 ,  C07D417/14

CPC分类号： C07D405/14 ,  A61P1/10 ,  C07D407/12 ,  C07D407/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the formula (I):




wherein R1 is a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, or an optionally substituted C1-6 alkoxy group; and ring A is an optionally further substituted ring, or a salt thereof.