公开(公告)号：US09957563B2

公开(公告)日：2018-05-01

申请号：US14548975

申请日：2014-11-20

Applicant: Isis Innovation Limited

Inventor： Emma Link ,  Sarah Parish ,  Rory Collins ,  Mark Lathrop

IPC: C12Q1/68

CPC classification number: C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172

Abstract: This invention relates to a method of determining the susceptibility of an individual to statin-induced myopathy, comprising detecting the presence or absence of one or more polymorphisms in the SLCO1B1 gene in a biological sample from an individual, whereby the presence of one or more polymorphisms indicates that the individual has altered susceptibility to statin-induced myopathy.

公开(公告)号：US20150079594A1

公开(公告)日：2015-03-19

申请号：US14548975

申请日：2014-11-20

Applicant: Isis Innovation Limited

Inventor： Emma Link ,  Sarah Parish ,  Rory Collins ,  Mark Lathrop

IPC: C12Q1/68

CPC classification number: C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172

Abstract: This invention relates to a method of determining the susceptibility of an individual to statin-induced myopathy, comprising detecting the presence or absence of one or more polymorphisms in the SLCO1B1 gene in a biological sample from an individual, whereby the presence of one or more polymorphisms indicates that the individual has altered susceptibility to statin-induced myopathy.

Abstract translation: 本发明涉及确定个体对他汀类药物诱导的肌病的易感性的方法，包括检测来自个体的生物样品中SLCO1B1基因中存在或不存在一种或多种多态性，由此存在一种或多种多态性 表明个体已经改变他汀类药物诱发的肌病的易感性。