Invention Application
- Patent Title: ANTIBODY-BINDING PROTEIN HAVING REDUCED ANTIBODY BINDING CAPACITY IN ACIDIC pH REGION
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Application No.: US15876610Application Date: 2018-01-22
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Publication No.: US20180215796A1Publication Date: 2018-08-02
- Inventor: Masakatsu Nishihachijyo , Yoshiyuki Nakano , Fuminori Konoike , Masayuki Takano , Shinichi Yoshida , Kazunobu Minakuchi
- Applicant: Kaneka Corporation
- Applicant Address: JP Osaka
- Assignee: Kaneka Corporation
- Current Assignee: Kaneka Corporation
- Current Assignee Address: JP Osaka
- Priority: JP2015-145006 20150722
- Main IPC: C07K14/31
- IPC: C07K14/31 ; C07K1/22

Abstract:
A protein includes an amino acid sequence derived from a sequence selected from the group consisting of SEQ ID NOs: 1 to 5. The amino acid sequence includes a substitution of a hydrophobic amino acid residue, an acidic amino acid residue, or a polar uncharged amino acid residue with a basic amino acid residue, and the protein has a reduced antibody-binding capacity in an acidic pH range, as compared to a protein including the amino acid sequence without the substitution.
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