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    THERAPEUTIC CONSTRUCTS COMPRISING CMET BINDING PEPTIDES
    2.
    发明申请
    THERAPEUTIC CONSTRUCTS COMPRISING CMET BINDING PEPTIDES 审中-公开

    公开(公告)号：US20200339629A1

    公开(公告)日：2020-10-29

    申请号：US16855292

    申请日：2020-04-22

    申请人： AEBI Ltd.

    发明人： Ilan MORAD ,  Hanan ITZHAKI

    IPC分类号： C07K7/08 ,  A61P35/00 ,  A61K47/60

    摘要： Constructs comprising a plurality of peptides are provided and their use in treating cancer. The construct optionally connected to an organic scaffold, comprise ate least one peptide capable of targeting the tumor antigen cMet, at least two peptides targeting two additional extracellular tumor antigens and a toxin. Specific peptide sequences binding to the extracellular tumor antigens cMet or EGFR are also provided.

    METHODS AND COMPOSITIONS FOR IDENTIFYING A PEPTIDE HAVING AN INTERMOLECULAR INTERACTION WITH A TARGET OF INTEREST
    3.
    发明申请
    METHODS AND COMPOSITIONS FOR IDENTIFYING A PEPTIDE HAVING AN INTERMOLECULAR INTERACTION WITH A TARGET OF INTEREST 审中-公开
    用于识别具有目标吸收的分子间相互作用的肽的方法和组合物

    公开(公告)号：US20160046929A1

    公开(公告)日：2016-02-18

    申请号：US14923855

    申请日：2015-10-27

    申请人： AEBI LTD.

    发明人： Ilan MORAD ,  Hanan ITZHAKI

    IPC分类号： C12N15/10

    CPC分类号： C12N15/1037 ,  C07K2319/50 ,  C07K2319/70 ,  C12N15/1058 ,  C40B10/00 ,  C40B40/02 ,  G01N33/5023 ,  G01N33/56983 ,  G01N2333/95

    摘要： This invention provides, in one embodiment, a recombinant virus or a recombinant virus library wherein each virus comprises a protein involved in viral attachment or infection, a polypeptide which differs by at least a single amino acid from another peptide or polypeptide in the library, and a modified cleavage site that is proximal to the peptide and the protein, wherein the cleavage site is modified such that a compound mediating cleavage has a reduced binding affinity for it as compared to a non-modified cleavage site. The invention further provides a target of interest complex comprising a protease, a target of interest involved in an intermolecular interaction, and a flexible linker that attaches the protease and target of interest. The invention further provides uses thereof, including a method for identifying a peptide which has an intermolecular interaction with a target of interest or identifying the agonistic or antagonistic feature of a peptide that has an intermolecular reaction with a target of interest.

    摘要翻译： 本发明在一个实施方案中提供了重组病毒或重组病毒文库，其中每个病毒包含参与病毒附着或感染的蛋白质，多肽与文库中的另一个肽或多肽至少单个氨基酸不同，以及 与肽和蛋白质接近的修饰的切割位点，其中修饰切割位点使得介导切割的化合物与未修饰的切割位点相比具有降低的结合亲和力。 本发明进一步提供了包含蛋白酶，涉及分子间相互作用的目标靶标的蛋白酶，以及附着蛋白酶和感兴趣靶标的柔性连接物的目标复合物。 本发明进一步提供其用途，包括鉴定与感兴趣的靶标具有分子间相互作用的肽或识别与感兴趣的靶标具有分子间反应的肽的激动或拮抗特征的方法。

    CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF
    4.
    发明申请
    CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF 有权

    公开(公告)号：US20210198319A1

    公开(公告)日：2021-07-01

    申请号：US16650557

    申请日：2018-09-20

    申请人： AEBI LTD.

    发明人： Ilan MORAD ,  Hanan ITZHAKI

    IPC分类号： C07K7/64 ,  A61P35/00 ,  A61K45/06

    摘要： The present invention provides cytotoxic peptides, analogs thereof and fragments thereof, conjugates of said peptides, analogs or fragments as well as compositions comprising same. In addition, uses of these compounds and compositions in treating cancer are provided.