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公开(公告)号：US20190249213A1
公开(公告)日：2019-08-15
申请号：US16345445
申请日：2017-10-27
CPC分类号： C12P19/62 , C07K2319/00 , C12N9/1029 , C12N15/52 , C12N15/74 , C40B40/02
摘要： The present disclosure provides proteins, nucleic acids, vectors, and host molecules useful for the production of compounds of interest, and methods for their use.
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公开(公告)号：US20190241929A1
公开(公告)日：2019-08-08
申请号：US16361016
申请日：2019-03-21
申请人： PhAST Corp.
发明人： Kwangmin Son , Roman Stocker
CPC分类号： C12Q1/04 , C40B30/06 , C40B40/02 , G01N33/9446 , G02B21/0084 , G02B21/365 , G16C10/00
摘要： Among other things, motility of at least one individual microorganism or a change in motility of at least one individual microorganism or both is or are characterized. The characterized motility or change in motility is used to detect the presence or count of the at least one individual microorganism, or determine the identity of a species or strain of the at least one individual microorganism, or determine a susceptibility of the at least one individual microorganism to one or more antibiotics or other antimicrobials.
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3.发明申请公开(公告)号：US20190194723A1
公开(公告)日：2019-06-27
申请号：US16311450
申请日：2017-06-23
申请人： Carlsberg A/S
发明人： Toni Wendt , Ole Olsen , Søren Knudsen , Hanne Cecille Thomsen , Birgitte Skadhauge , Magnus Wohlfahrt Rasmussen , Massimiliano Carciofi , Alexander Striebeck
IPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6876 , C12Q1/6827 , A01H6/46 , A01H5/10
CPC分类号： C12Q1/686 , A01H5/10 , A01H6/4624 , C12N15/01 , C12N15/1024 , C12Q1/6806 , C12Q1/6827 , C12Q1/6876 , C40B30/00 , C40B40/02
摘要： In traditional plant breeding approaches, chemical mutagenesis may be utilized to introduce nucleotide substitutions at random in the genome of a plant, i.e. without possibilities to control the sites of nucleotide changes. Because of genome complexities, the statistical probability is extremely little when it comes to finding a predetermined nucleotide substitution. The present invention, however, demonstrates how a novel, alternative use of digital polymerase chain reaction (dPCR), preferably droplet dPCR (ddPCR), is developed to exploit finding of specific nucleotide substitutions in mutated genes. The entire platform comprises a screening method with a library of mutagenized organisms, digital PCR-based systems and a set-up to propagate and analyze identified, mutated organisms.
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公开(公告)号：US10323242B1
公开(公告)日：2019-06-18
申请号：US16269671
申请日：2019-02-07
申请人： Inscripta, Inc.
发明人： Don Masquelier , Phillip Belgrader , Jorge Bernate , Ryan Gill , Kevin Ness
IPC分类号： C12N15/00 , C12M3/00 , B01L3/00 , C12N15/10 , C40B40/02 , C12M1/36 , C12N15/11 , C12M1/12 , C12M1/00 , C12N9/22
CPC分类号： C12N15/1082 , C12M23/44 , C12M33/14 , C12M35/00 , C12M37/04 , C12M41/36 , C12M41/48 , C12M43/00 , C12N9/22 , C12N15/11 , C12N2310/20 , C12N2800/80 , C40B40/02
摘要： In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one or more cells.
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公开(公告)号：US10018618B2
公开(公告)日：2018-07-10
申请号：US15138048
申请日：2016-04-25
发明人： Elliot Altman
IPC分类号： C12N15/00 , C12N15/62 , G01N33/50 , C07K7/06 , C07K7/08 , C07K7/14 , C07K14/195 , C07K14/245 , C07K14/425 , C07K14/585 , C07K14/59 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/645 , C12N15/10 , C12N15/63 , C12N15/67 , C12N15/72 , C40B40/02 , G01N33/68 , C07K14/435 , C07K14/46 , C07K14/575 , C07K14/58 , C07K14/63 , C07K14/655 , C07K14/665 , A61K38/00
CPC分类号： G01N33/5008 , C07K7/06 , C07K7/08 , C07K7/14 , C07K14/195 , C07K14/245 , C07K14/425 , C07K14/435 , C07K14/43536 , C07K14/43568 , C07K14/43572 , C07K14/463 , C07K14/575 , C07K14/58 , C07K14/585 , C07K14/59 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/63 , C07K14/645 , C07K14/655 , C07K14/665 , C07K2319/00 , C12N15/1037 , C12N15/62 , C12N15/635 , C12N15/67 , C12N15/72 , C40B40/02 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/68 , G01N33/6845
摘要： An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus identified are inherently protease- and peptidase-resistant. Also provided are bioactive peptides stabilized by a stabilizing group at the N-terminus, the C-terminus, or both. The stabilizing group can be a small stable protein, such as the Rop protein, glutathione sulfotransferase, thioredoxin, maltose binding protein, or glutathione reductase, an α-helical moiety, or one or more proline residues.
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公开(公告)号：US10017757B2
公开(公告)日：2018-07-10
申请号：US14805284
申请日：2015-07-21
CPC分类号： C12N15/1044 , C07K14/245 , C07K2319/03 , C07K2319/22 , C07K2319/60 , C12N15/1037 , C12Q1/37 , C40B40/02 , C40B40/10 , G01N21/6486
摘要： The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and C-terminal candidate peptide presenting domains that when expressed in a cell are accessible at a surface of the cell outermembrane. In addition, the present invention also provides kits and methods for screening a library of cells presenting the candidate peptides in peptide display scaffolds to identify a ligand for an enzyme.
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公开(公告)号：US09845464B2
公开(公告)日：2017-12-19
申请号：US14517223
申请日：2014-10-17
申请人： GLYCOFI, INC.
发明人： Dongxing Zha , Stefan Wildt
IPC分类号： C40B40/08 , C12N15/10 , C07K16/00 , C07K16/28 , C07K16/32 , C07K16/40 , C40B40/02 , C40B50/06
CPC分类号： C12N15/1037 , C07K16/005 , C07K16/2887 , C07K16/32 , C07K16/40 , C07K2317/51 , C07K2317/55 , C12N15/1055 , C40B40/02 , C40B40/08 , C40B50/06
摘要： Methods for display of recombinant proteins or protein libraries on the surface of lower eukaryotes such as yeast and filamentous fungi are described. The methods are useful for screening libraries of recombinant proteins in lower eukaryotes to identify particular proteins with desired properties from the array of proteins in the libraries. The methods are particularly useful for constructing and screening antibody libraries in lower eukaryotes.
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公开(公告)号：US20170334958A1
公开(公告)日：2017-11-23
申请号：US15583561
申请日：2017-05-01
IPC分类号： C07K14/47 , C07K16/00 , C12N15/10 , C40B40/02 , C12Q1/00 , C07K14/525 , C07K14/78 , C07K16/24
CPC分类号： C07K14/47 , C07K14/525 , C07K14/78 , C07K16/00 , C07K16/241 , C07K2317/22 , C07K2318/20 , C07K2319/00 , C07K2319/30 , C12N15/1037 , C12Q1/00 , C40B40/02
摘要： Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.
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公开(公告)号：US09803190B2
公开(公告)日：2017-10-31
申请号：US13754261
申请日：2013-01-30
申请人： Dyax Corp.
CPC分类号： C12N15/1037 , C07K16/00 , C07K16/005 , C07K2317/565 , C40B40/02 , C40B40/08 , C40B40/10
摘要： Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family. The libraries have length and sequence diversities that mimic that found in native human antibodies.
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公开(公告)号：US09803189B2
公开(公告)日：2017-10-31
申请号：US11895198
申请日：2007-08-23
申请人： David S. Peabody , Bryce Chackerian
发明人： David S. Peabody , Bryce Chackerian
IPC分类号： C40B40/02 , C12N15/10 , C07K14/005 , A61K39/00
CPC分类号： C12N15/1037 , A61K2039/5256 , A61K2039/5258 , C07K14/005 , C12N2740/16122 , C12N2795/18123 , C40B40/02
摘要： The invention is directed to virus-like particles (VLPs) of an RNA bacteriophage that (a) comprises a coat polypeptide of said phage modified by insertion of a heterologous peptide that is displayed on said VLP and (b) encapsidates said bacteriophage mRNA as well as populations of these VLPs, and their uses. The invention is further directed to VLPs that encapsidate heterologous substances, as well as populations of these VLPs and their uses.
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