公开(公告)号：US12029780B2

公开(公告)日：2024-07-09

申请号：US17549017

申请日：2021-12-13

Applicant: OPKO BIOLOGICS LTD.

Inventor： Fuad Fares ,  Udi Eyal Fima

IPC: A61K38/27 ,  A61K38/24 ,  A61K47/00 ,  A61K47/02 ,  A61K47/12 ,  C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/59 ,  C07K14/61 ,  C07K19/00 ,  G01N33/74

CPC classification number: A61K38/27 ,  A61K38/24 ,  A61K47/02 ,  A61K47/12 ,  C07K14/505 ,  C07K14/555 ,  C07K14/59 ,  C07K14/61 ,  G01N33/74 ,  C07K2319/00 ,  C07K2319/31 ,  G01N2333/65 ,  G01N2800/52

Abstract: CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.

公开(公告)号：US20230218729A1

公开(公告)日：2023-07-13

申请号：US17759740

申请日：2021-03-12

Applicant: BIOAPPLICATIONS INC.

Inventor： Eun-Ju SOHN ,  Yong Jik LEE

IPC: A61K39/00 ,  C07K14/59 ,  C07K14/28 ,  A61P15/00

CPC classification number: A61K39/0006 ,  C07K14/59 ,  C07K14/28 ,  A61P15/00 ,  A61K2039/6037 ,  C07K2319/30 ,  A61K2039/6056

Abstract: The present invention relates to a vaccine composition which is form neutering or spaying an animal and comprises a recombinant protein in which cholera toxin B subunit (CTB) and gonadotropin-releasing hormone (GnRH) are fused. More specifically, provided are: a recombinant protein for neutering or spaying an animal and for inducing antibodies against GnRH; a recombinant vector for producing the recombinant protein; a vaccine composition for neutering or spaying an animal, the vaccine composition comprising the recombinant protein; and a method for neutering or spaying an animal by using the vaccine composition. The vaccine composition according to the present invention induces antibodies against GnRH in an individual, thereby atrophying the ovaries or testes thereof. Therefore, the present invention can, at low cost, a high level of safety, and with minimal side effects, replace surgical procedures for neutering and spaying, and be beneficially used to neuter or spay an animal.

公开(公告)号：US20230024202A1

公开(公告)日：2023-01-26

申请号：US17782422

申请日：2020-12-03

Applicant: FRESENIUS KABI USA, LLC

Inventor： Jagdish LANDE ,  Kamlesh PATEL ,  Umer RAHEEMI

IPC: C07K1/16 ,  G01N33/76 ,  C07K14/59 ,  B01J20/26 ,  B01D15/42

Abstract: Provided are methods for analyzing and purifying degarelix or a pharmaceutically acceptable salt thereof containing at least one related impurity. Also provided are methods for analyzing and purifying degarelix or a pharmaceutically acceptable salt thereof containing compound A and/or compound D as an impurity. Further provided are degarelix or a pharmaceutically acceptable salt thereof prepared from and/or selected using the disclosed methods.

公开(公告)号：US20220340634A1

公开(公告)日：2022-10-27

申请号：US17709296

申请日：2022-03-30

Applicant: Frering B.V.

Inventor： Ian COTTINGHAM ,  Daniel PLAKSIN ,  Rrichard WHITE

IPC: C07K14/575 ,  C07K14/59 ,  C12P21/00

Abstract: The present disclosure describes recombinant human chorionic gonadotropin (hCG) and methods for the production thereof. The recombinant hCG can include α2,3, α2,6, and, optionally, α2,8 sialylation. The recombinant hCG can be produced in a human cell line such as a PER.C6® cell line.

公开(公告)号：US20220289810A1

公开(公告)日：2022-09-15

申请号：US17638118

申请日：2019-08-30

Applicant: Alejandro Dario ABENTIN ,  Syntex S.A.

Inventor： Juan Manuel PEREZ SAEZ ,  Leonardo Edmundo BUSSMANN

IPC: C07K14/59

Abstract: This invention relates to a recombinant single chain chorionic gonadotropin polypeptide, having an amino acid sequence encoding the beta chain and the alpha chain of the equine chorionic gonadotropin linked to one or more sequences that include glycosylation sites, which results in excellent in vitro and in vivo activity. The DNA molecules that encode the recombinant polypeptide are also taught, an expression vector comprising these DNA molecules, compositions comprising the recombinant protein and methods for preparing them are also disclosed.

公开(公告)号：US11439668B2

公开(公告)日：2022-09-13

申请号：US15947304

申请日：2018-04-06

Applicant: JangoBio, LLC

Inventor： Craig S. Atwood ,  Sivan Vadakkadath Meethal

IPC: A61K35/545 ,  A61K35/52 ,  A61K35/55 ,  A61P5/24 ,  A61P5/06 ,  C07K14/59 ,  A61K35/54 ,  A61K35/15 ,  A61K31/568 ,  A61K31/566 ,  A61K31/57 ,  A61K9/00

Abstract: Methods are described for differentiating stem and post-natal cells into sex hormone-producing cells that can be administered to a patient autologously or allogeneically in order to maintain in balance, or rebalance, their hypothalamic-pituitary-gonadal (HPG) axis.

公开(公告)号：US20220170005A1

公开(公告)日：2022-06-02

申请号：US17379504

申请日：2021-07-19

Applicant: OPKO BIOLOGICS LTD.

Inventor： Udi Eyal FIMA ,  Gili HART

IPC: C12N9/64 ,  C12N9/96 ,  C07K14/505 ,  C07K14/59 ,  C07K14/745

Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

公开(公告)号：US11197915B2

公开(公告)日：2021-12-14

申请号：US15200813

申请日：2016-07-01

Applicant: OPKO Biologies Ltd.

Inventor： Fuad Fares ,  Udi Eyal Fima

IPC: A61K38/27 ,  C07K14/61 ,  C07K14/59 ,  A61K38/24 ,  C07K14/555 ,  C07K14/505 ,  A61K47/02 ,  A61K47/12 ,  G01N33/74

Abstract: CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.

公开(公告)号：US11168125B2

公开(公告)日：2021-11-09

申请号：US16518642

申请日：2019-07-22

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Robert T. Peters ,  Adam R. Mezo ,  Daniel S. Rivera ,  Alan J. Bitonti ,  Susan C. Low

IPC: C07K14/755 ,  C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/56 ,  C07K14/745 ,  C07K16/00 ,  C12N9/64 ,  A61K47/68 ,  C07K14/565 ,  C12N9/96 ,  A61K47/60 ,  C07K14/59 ,  C07K14/61 ,  C07K14/705 ,  A61K47/64 ,  A61K38/00

Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

公开(公告)号：US10995128B2

公开(公告)日：2021-05-04

申请号：US15690061

申请日：2017-08-29

Applicant: Ferring International Center SA

Inventor： Ian Cottingham ,  Daniel Plaksin ,  Richard Boyd White

IPC: C07K14/59 ,  A61K38/00

Abstract: Preparations including recombinant FSH (rFSH).