公开(公告)号：US10537646B2

公开(公告)日：2020-01-21

申请号：US14405597

申请日：2013-06-04

申请人： OPKO Biologics Ltd.

发明人： Udi Eyal Fima ,  Oren Hershkovitz

IPC分类号： A61K38/26 ,  C07K14/605 ,  C07K1/00 ,  A61K47/60 ,  A61K38/22

摘要： A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a reversible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed.

公开(公告)号：US09908924B2

公开(公告)日：2018-03-06

申请号：US14555246

申请日：2014-11-26

申请人： OPKO Biologics Ltd.

发明人： Fuad Fares ,  Udi Eyal Fima

IPC分类号： C07K14/505 ,  C12N15/62 ,  A61K38/18 ,  C07K14/59 ,  C07K14/61 ,  C07K14/555 ,  C07K14/605

CPC分类号： C07K14/59 ,  A61K38/1816 ,  C07K14/505 ,  C07K14/555 ,  C07K14/605 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31

摘要： A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also discarded.

公开(公告)号：US09884901B2

公开(公告)日：2018-02-06

申请号：US14566681

申请日：2014-12-10

申请人： OPKO Biologics Ltd.

发明人： Fuad Fares ,  Udi Eyal Fima

IPC分类号： A61K38/18 ,  C07K14/505 ,  C07K14/61 ,  C07K14/555 ,  C07K14/59

CPC分类号： C07K14/505 ,  C07K14/555 ,  C07K14/59 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31

摘要： A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.

公开(公告)号：US09828417B2

公开(公告)日：2017-11-28

申请号：US14555258

申请日：2014-11-26

申请人： OPKO Biologics Ltd.

发明人： Udi Eyal Fima ,  Gili Hart

IPC分类号： A61K38/18 ,  C07K14/505 ,  C07K14/59 ,  C07K14/61 ,  C07K14/555

CPC分类号： C07K14/59 ,  C07K14/505 ,  C07K14/555 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/35

摘要： A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.

公开(公告)号：US10960058B2

公开(公告)日：2021-03-30

申请号：US15737979

申请日：2016-06-19

申请人： OPKO BIOLOGICS LTD.

发明人： Udi Eyal Fima ,  Gili Hart

IPC分类号： A61K38/00 ,  C12Q1/56 ,  A61K9/19 ,  A61K9/64 ,  A61P7/04 ,  C07K14/59 ,  A61K38/48 ,  C12N9/64 ,  A61K9/00

摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.

公开(公告)号：US20160310576A1

公开(公告)日：2016-10-27

申请号：US15200813

申请日：2016-07-01

申请人： OPKO Biologics Ltd.

发明人： Fuad FARES ,  Udi Eyal Fima

IPC分类号： A61K38/27 ,  G01N33/74 ,  A61K47/02 ,  A61K38/24 ,  A61K47/12

CPC分类号： A61K38/27 ,  A61K38/24 ,  A61K47/02 ,  A61K47/12 ,  C07K14/505 ,  C07K14/555 ,  C07K14/59 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31 ,  G01N33/74 ,  G01N2333/65 ,  G01N2800/52

摘要： CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.

公开(公告)号：US20150152155A1

公开(公告)日：2015-06-04

申请号：US14550346

申请日：2014-11-21

申请人： OPKO BIOLOGICS LTD.

发明人： Fuad FARES ,  Udi Eyal Fima

IPC分类号： C07K14/505 ,  C07K14/59

CPC分类号： C07K14/555 ,  A61K38/19 ,  A61K47/64 ,  C07K14/505 ,  C07K14/59 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/35 ,  C07K2319/91

摘要： A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.

公开(公告)号：US20150072924A1

公开(公告)日：2015-03-12

申请号：US14395441

申请日：2013-04-17

申请人： OPKO Biologics Ltd.

发明人： Udi Eyal Fima ,  Oren Hershkovitz

IPC分类号： C07K14/575 ,  C07K14/59

CPC分类号： C07K14/575 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/24 ,  A61K38/26 ,  C07K14/59 ,  C07K14/605 ,  C07K2319/75

摘要： This invention is directed to a chorionic gonadotrophin carboxy terminal peptide (CTP) modified dual GLP-1/Glucagon receptor agonist, and methods of producing and using the same. In one embodiment, the present invention provides a CTP-modified polypeptide comprising a dual GLP-1/Glucagon receptor agonist and at least one chorionic gonadotrophin carboxy terminal peptide (CTP) attached to the amino terminus or carboxy terminus of said agonist.

摘要翻译： 本发明涉及绒毛膜促性腺激素羧基末端肽（CTP）修饰的双重GLP-1 /胰高血糖素受体激动剂及其制备和使用方法。 在一个实施方案中，本发明提供了包含双GLP-1 /胰高血糖素受体激动剂和连接于所述激动剂的氨基末端或羧基末端的至少一个绒毛膜促性腺激素羧基末端肽（CTP）的CTP-修饰的多肽。

公开(公告)号：US10144921B2

公开(公告)日：2018-12-04

申请号：US15159641

申请日：2016-05-19

申请人： OPKO Biologics Ltd.

发明人： Udi Eyal Fima ,  Gili Hart

IPC分类号： C07K14/00 ,  C07K16/00 ,  A61K38/00 ,  C12N9/50 ,  C07K14/505 ,  C07K14/59 ,  C07K14/745 ,  C12N9/64 ,  A61K47/64

摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

公开(公告)号：US10119132B2

公开(公告)日：2018-11-06

申请号：US14948890

申请日：2015-11-23

申请人： OPKO Biologics Ltd.

发明人： Udi Eyal Fima ,  Gili Hart

IPC分类号： A61K38/36 ,  C07K14/745 ,  C12N9/64 ,  C12N9/96 ,  C07K14/505 ,  C07K14/59 ,  A61K38/00 ,  A61K38/48

摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.