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公开(公告)号：US20240093177A1
公开(公告)日：2024-03-21
申请号：US18333339
申请日：2023-06-12
Applicant: VACCINEX, INC.
Inventor： Malgorzata Gil-Moore , Maria G.M Scrivens , Renee A. Kirk , Leslie A. Balch , Loretta L. Mueller , Ernest S. Smith
CPC classification number: C12N15/1044 , C07K16/2887 , C07K16/2896 , C12N15/1013 , C12N15/1065
Abstract: This disclosure provides compositions and methods for high throughput screening, selecting, and identifying antibodies or antibody-like molecules that bind to a target integral membrane protein.
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公开(公告)号：US20230242617A1
公开(公告)日：2023-08-03
申请号：US17889123
申请日：2022-08-16
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Dasa LIPOVSEK , Jonathan H. DAVIS
CPC classification number: C07K14/78 , G01N33/6845 , C07K16/244 , C07K16/28 , C07K16/2833 , C07K16/2857 , C12N15/1044
Abstract: Fibronectin type III (10Fn3) binding domains having novel designs that are associated with reduced immunogenicity are provided. The application describes alternative 10Fn3 binding domains in which certain immunogenic regions are not modified when producing a binder in order to maintain recognition as a self antigen by the host organism. The application also describes 10Fn3 binding domains in which HLA anchor regions have been destroyed thereby reducing the immunogenic contribution of the adjoining region. Also provided are 10Fn3 domains having novel combinations of modified regions that can bind to a desired target with high affinity.
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公开(公告)号：US10017757B2
公开(公告)日：2018-07-10
申请号：US14805284
申请日：2015-07-21
Applicant: The Regents of the University of California
Inventor： Patrick Sean Daugherty , Kevin Todd Boulware
CPC classification number: C12N15/1044 , C07K14/245 , C07K2319/03 , C07K2319/22 , C07K2319/60 , C12N15/1037 , C12Q1/37 , C40B40/02 , C40B40/10 , G01N21/6486
Abstract: The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and C-terminal candidate peptide presenting domains that when expressed in a cell are accessible at a surface of the cell outermembrane. In addition, the present invention also provides kits and methods for screening a library of cells presenting the candidate peptides in peptide display scaffolds to identify a ligand for an enzyme.
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公开(公告)号：US20170253645A1
公开(公告)日：2017-09-07
申请号：US15433745
申请日：2017-02-15
Applicant: PROTELICA, INC.
Inventor： Guido Cappuccilli , Roberto Crea , Randy Shen , Craig A. Hokanson , Peter B. Kirk , David R. Liston
CPC classification number: C07K14/78 , C07K16/18 , C07K16/22 , C07K16/241 , C07K2317/21 , C07K2317/52 , C07K2318/20 , C12N15/1044
Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
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公开(公告)号：US20160194626A1
公开(公告)日：2016-07-07
申请号：US14828763
申请日：2015-08-18
Applicant: Andreas LOEW , Brian VASH
Inventor： Andreas LOEW , Brian VASH
IPC: C12N15/10 , G01N33/566
CPC classification number: C12N15/1037 , C12N15/1044 , C40B30/02 , C40B40/10 , C40B50/02 , G01N33/566 , G06F19/16
Abstract: The invention pertains to a natural-variant combinatorial library of fibronectin Type 3 domain (Fn3) polypeptides useful in screening for the presence of one or more polypeptides having a selected binding or enzymatic activity. The library polypeptides include (a) regions A, AB, B, C, CD, D, E, EF, F, and G having wildtype amino acid sequences of a selected native fibronectin Type 3 polypeptide or polypeptides, and (b) loop regions AB, CD, and EF having selected lengths (Bottom Loops). The Fn3 may also have loop regions BC, DE, and FG having wildtype amino acid sequences, having selected lengths, or mutagenized amino acid sequences (Top Loops).
Abstract translation: 本发明涉及可用于筛选具有选定结合或酶活性的一种或多种多肽的存在的纤连蛋白3型结构域（Fn3）多肽的天然变体组合文库。 文库多肽包括（a）具有所选天然纤连蛋白3型多肽或多肽的野生型氨基酸序列的区域A，AB，B，C，CD，D，E，EF，F和G，和（b）环区 AB，CD和EF，具有选定的长度（底部循环）。 Fn3还可以具有具有野生型氨基酸序列，具有选定长度或诱变的氨基酸序列（Top Loops）的环区BC，DE和FG。
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Patent Agency Ranking
公开(公告)号：US09234847B2
公开(公告)日：2016-01-12
申请号：US12646323
申请日：2009-12-23
Applicant: Patrick Sean Daugherty , Kevin Todd Boulware
Inventor： Patrick Sean Daugherty , Kevin Todd Boulware
CPC classification number: C12N15/1044 , C07K14/245 , C07K2319/03 , C07K2319/22 , C07K2319/60 , C12N15/1037 , C12Q1/37 , C40B40/02 , C40B40/10 , G01N21/6486
Abstract: The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and C-terminal candidate peptide presenting domains that when expressed in a cell are accessible at a surface of the cell outermembrane. In addition, the present invention also provides kits and methods for screening a library of cells presenting the candidate peptides in peptide display scaffolds to identify a ligand for an enzyme.
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公开(公告)号：US09127090B2
公开(公告)日：2015-09-08
申请号：US13172605
申请日：2011-06-29
Applicant: Shohei Koide
Inventor： Shohei Koide
IPC: C12N5/10 , C07H21/04 , C12N15/63 , C07K14/78 , C07K16/00 , C12N15/10 , C40B40/02 , G01N33/68 , C07K16/18 , C07K16/40 , G01N33/78
CPC classification number: C07K14/78 , C07K16/00 , C07K16/18 , C07K16/40 , C07K2317/565 , C07K2318/20 , C12N15/1037 , C12N15/1044 , C40B40/02 , G01N33/68 , G01N33/6845 , G01N33/78 , G01N2333/78
Abstract: A fibronectin type III (Fn3) polypeptide monobody, a nucleic acid molecule encoding said monobody, and a variegated nucleic acid library encoding said monobody, are provided by the invention. Also provided are methods of preparing a Fn3 polypeptide monobody, and kits to perform said methods. Further provided is a method of identifying the amino acid sequence of a polypeptide molecule capable of binding to a specific binding partner (SBP) so as to form a polypeptide:SSP complex, and a method of identifying the amino acid sequence of a polypeptide molecule capable of catalyzing a chemical reaction with a catalyzed rate constant, kcat, and an uncatalyzed rate constant, kuncat, such that the ratio of kcat/kuncat is greater than 10.
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公开(公告)号：US09090892B2
公开(公告)日：2015-07-28
申请号：US13845984
申请日：2013-03-18
Applicant: Monsanto Technology LLC
Inventor： Jennifer Jones
IPC: C12N15/09 , C12N15/10 , C07K14/415 , C12N9/16
CPC classification number: C12N15/1068 , C07K14/415 , C12N9/16 , C12N15/1044
Abstract: Libraries of nucleic acids encoding chimeric binding polypeptides based on plant scaffold polypeptide sequences. Also described are methods for generating the libraries.
Abstract translation: 基于植物支架多肽序列编码嵌合结合多肽的核酸的文库。 还描述了用于生成库的方法。
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公开(公告)号：US08927693B2
公开(公告)日：2015-01-06
申请号：US13579204
申请日：2011-02-16
Applicant: Ruchira Dasgupta , Alex Bush , Lumelle Schneeweis , Linda Engle
Inventor： Ruchira Dasgupta , Alex Bush , Lumelle Schneeweis , Linda Engle
CPC classification number: C07K14/78 , A61K38/00 , A61K38/39 , A61K47/60 , C07K2318/20 , C07K2319/70 , C12N15/1044
Abstract: The present invention relates to fibronectin based scaffold domain protein that bind interleukin 23 (IL-23), specifically the p19 subunit of IL-23. The invention also relates to the use of the innovative proteins in therapeutic applications to treat autoimmune diseases. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
Abstract translation: 本发明涉及结合白介素23（IL-23），特别是IL-23的p19亚基的基于纤连蛋白的支架结构域蛋白。 本发明还涉及创新蛋白在治疗应用中用于治疗自身免疫性疾病的用途。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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10.发明申请Protease-Resistant Systems for Polypeptide Display and Methods of Making and Using Thereof 有权用于多肽显示的蛋白酶抗性系统及其制备和使用方法公开(公告)号：US20140235467A1
公开(公告)日：2014-08-21
申请号：US13963769
申请日：2013-08-09
Applicant: CytomX Therapeutics, Inc.
Inventor： Sherry Lynn La Porte , Stephen James Moore , James William West
CPC classification number: C12N15/1037 , C07K14/001 , C07K14/705 , C07K16/18 , C07K16/2809 , C07K16/2866 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C07K2319/21 , C12N15/1044 , C12Q1/37 , C40B40/02 , G01N33/6845
Abstract: The present invention generally relates to bacterial polypeptide display systems, libraries using these bacterial display systems, and methods of making and using these systems, including methods for improved display of polypeptides on the extracellular surface of bacteria using circularly permuted transmembrane bacterial polypeptides that have been modified to increase resistance to protease degradation and to enhance polypeptide display characteristics.
Abstract translation: 本发明一般涉及细菌多肽展示系统，使用这些细菌显示系统的文库，以及制备和使用这些系统的方法，包括使用经修饰的环状置换的跨膜细菌多肽来改善细菌细胞外表面多肽的显示方法 以增加对蛋白酶降解的抗性并增强多肽显示特征。
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