公开(公告)号：US20170253645A1

公开(公告)日：2017-09-07

申请号：US15433745

申请日：2017-02-15

Applicant: PROTELICA, INC.

Inventor： Guido Cappuccilli ,  Roberto Crea ,  Randy Shen ,  Craig A. Hokanson ,  Peter B. Kirk ,  David R. Liston

IPC: C07K14/78 ,  C07K16/24 ,  C12N15/10 ,  C07K16/18 ,  C07K16/22

CPC classification number: C07K14/78 ,  C07K16/18 ,  C07K16/22 ,  C07K16/241 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2318/20 ,  C12N15/1044

Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.

公开(公告)号：US20140206576A1

公开(公告)日：2014-07-24

申请号：US14150712

申请日：2014-01-08

Applicant: PROTELICA, INC.

Inventor： Guido Cappuccilli ,  Roberto Crea ,  Randy Shen ,  Craig A. Hokanson ,  Peter B. Kirk ,  David R. Liston

IPC: C07K14/78

CPC classification number: C07K14/78 ,  C07K16/18 ,  C07K16/22 ,  C07K16/241 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2318/20 ,  C12N15/1044

Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.

Abstract translation: 描述了直通诱变和自然变体组合纤连蛋白III（FN3）多肽文库以及它们的构建和使用方法。 还公开了通过针对多种选择的抗原筛选文库而选择的多种高结合亲和力多肽。