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公开(公告)号：US20240174723A1
公开(公告)日：2024-05-30
申请号：US18281403
申请日：2022-03-11
发明人： Rida Mourtada , Warren A. Dorsch
CPC分类号： C07K14/463 , A61K9/5123 , A61K47/60 , A61P31/04 , A61K38/00
摘要： Provided are stapled antimicrobial peptides (i.e., StAMPs) and methods of using the same (e.g., for treating bacterial infections caused by Gram-negative bacteria). In certain embodiments, the stapled peptides are based on the amino acid sequence of the antimicrobial peptide Magainin II, but include certain modifications that have been found to confer advantageous properties (e.g., improved antimicrobial activity, selectivity for killing Gram-negative bacteria, and/or reduced toxicity). Also provided are unstapled peptides which can serve as synthetic precursors to the stapled peptides provided herein
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公开(公告)号：US11987607B2
公开(公告)日：2024-05-21
申请号：US18053981
申请日：2022-11-09
IPC分类号： C07K14/37 , C07K14/435 , C07K14/46 , C07K14/465 , C07K14/47 , G16B15/20
CPC分类号： C07K14/4723 , C07K14/43518 , C07K14/43522 , C07K14/43568 , C07K14/43572 , C07K14/43581 , C07K14/463 , C07K14/465 , G16B15/20
摘要： Computational systems and methods are described for identifying new α-helical antimicrobial peptides using a systemic consensus formula. Newly identified α-helical antimicrobial peptides are tested experimentally and show potent microbiocidal activities.
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公开(公告)号：US20240109944A1
公开(公告)日：2024-04-04
申请号：US17768636
申请日：2020-10-09
申请人： UNIVERSITÀ DEGLI STUDI DI ROMA LA SAPIENZA , Fondazione Per La Ricerca Sulla Fibrosi Cistica , Istituto Giannina Gaslini
CPC分类号： C07K14/463 , A61K45/06 , A61P11/00
摘要： Are disclosed pharmaceutical compositions comprising as active ingredients Esculentin-1a(1-21)NH2 and/or Esculentin diastereomer Esc(1-21)-1c for use for restoring dysregulation of water and/or ions content and/or composition of the periciliary liquid due to mutations of the CFTR gene encoding for Cystic fibrosis transmembrane conductance regulator (CFTR) and for use for the treatment of cystic fibrosis.
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公开(公告)号：US20230391839A1
公开(公告)日：2023-12-07
申请号：US18322507
申请日：2023-05-23
发明人： Harald Martijn Ijsbrand Kerkkamp , Michael Keith Richardson , Gilles Philippus van Wezel , Jan Wouter Drijfhout , Robert Alexander Cordfunke , Michella Manon Voet , Petrus Hendricus Nibbering
IPC分类号： C07K14/46
摘要： The disclosure concerns snake-derived peptides and the useful application of such peptides to inhibit bacterial, fungal, viral and parasitic infections. The disclosed peptides are also useful for the treatment of an inflammatory condition or cancers.
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公开(公告)号：US11806382B2
公开(公告)日：2023-11-07
申请号：US16951650
申请日：2020-11-18
发明人： Anil K. Chauhan , Nirav A. Dhanesha
IPC分类号： A61K38/10 , A61K38/39 , A61P9/10 , A61K38/18 , A61K38/17 , A61K38/19 , A61K39/395 , A61P29/00 , C07K16/28 , A61K39/00 , A61K9/00 , C07K14/47 , C07K7/08 , C07K14/78 , C07K14/46 , C07K14/705 , C07K14/52
CPC分类号： A61K38/10 , A61K38/1703 , A61K38/1709 , A61K38/1774 , A61K38/1866 , A61K38/19 , A61K38/39 , A61K39/3955 , A61P9/10 , A61P29/00 , A61K9/0019 , A61K2039/505 , A61K2039/54 , C07K7/08 , C07K14/46 , C07K14/47 , C07K14/4703 , C07K14/52 , C07K14/70503 , C07K14/78 , C07K16/2842 , C07K2317/76
摘要： The invention provides a method and kits for inhibiting integrin α9β1 activity comprising contacting integrin α9β1 or a binding partner of integrin α9β1 with an isolated anti-integrin α9 inhibitor, wherein the integrin α9β1 activity is inhibited. In certain aspects, the present invention provides a novel intervention by targeting integrin α9β1 with a functional blocking inhibitor (e.g., peptides or antibodies) to limit brain damage following reperfusion after ischemic stroke.
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公开(公告)号：US20230295597A1
公开(公告)日：2023-09-21
申请号：US18041493
申请日：2021-08-12
CPC分类号： C12N9/6489 , C07K14/46 , A61K38/1703 , C12Y304/24087 , A61K38/4886 , C12Y304/24068 , A61K38/36 , A61P7/02 , C07K2319/35
摘要： The present invention relates to ADAMTS-13 mutants and/or variant/s that display resistance to tPA cleavage and/or inactivation. The present disclosure further provides fibrinolytic compounds, compositions, combined compositions and kits comprising the ADAMTS-13 mutants disclosed herein, as well as uses thereof for treating coagulation related disorders.
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公开(公告)号：US20230151067A1
公开(公告)日：2023-05-18
申请号：US17740837
申请日：2022-05-10
发明人： Tingting LI , Zhe XU , Jianrong Li , Zhixuan Zhu , Lingyu Han , Yu Zou , Kun Ma
CPC分类号： C07K14/461 , C12P21/06
摘要： The present disclosure provides a preparation method of a surimi low-molecular-weight antifreeze peptide, and relates to the technical field of processing of aquatic products. The preparation method includes the following steps: step 1, with Larimichthys crocea as a raw material, decapitating and gutting the L. crocea, crushing the L. crocea into a surimi, decalcifying the surimi, extracting water-soluble crude protein with water, and freeze-drying to obtain the water-extracted crude protein powder of L. crocea; step 2, redissolving the water-extracted crude protein powder of L. crocea obtained in step 1 with water, and enzymatically hydrolyzing it with protease to obtain an enzymatic hydrolysate; and step 3, sonicating and dialyzing the enzymatic hydrolysate obtained in step 2 to obtain a dialysate with a molecular weight no more than 3,500 D, and freeze-drying the dialysate to obtain the surimi low-molecular-weight antifreeze peptide.
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公开(公告)号：US11385236B2
公开(公告)日：2022-07-12
申请号：US16347765
申请日：2017-11-30
IPC分类号： G01N33/58 , C07K14/195 , C07K14/215 , C07K14/435 , C07K14/46 , C07K14/465 , C12N9/14 , G01N21/64 , G01N33/566
摘要： Provided herein are a voltage indicator and a method of measuring voltage. The voltage indicator includes a membrane-localized voltage-sensitive protein coupled to a capture protein. The method of measuring voltage includes administering a voltage indicator including a membrane-localized voltage-sensitive protein coupled to a capture protein, and determining changes in fluorescence of a small-molecule fluorescent dye captured by the capture protein.
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公开(公告)号：US11384134B2
公开(公告)日：2022-07-12
申请号：US16857130
申请日：2020-04-23
申请人： Emory University
IPC分类号： C07K14/46 , C12N15/00 , C07K14/725
摘要： This disclosure relates to variable lymphocyte receptors (VLRs) modifications such as humanized sequences and polypeptides comprising such sequences that specifically bind a target molecule and uses related thereto. In certain embodiments, the disclosure relates to recombinant polypeptide VLRs disclosed herein and variants thereof. In certain embodiments, this disclosure relates to treating or preventing a disease or condition comprising administering an effective amount of a recombinant polypeptide or variant disclosed herein to a subject in need thereof.
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10.发明申请公开(公告)号：US20220091102A1
公开(公告)日：2022-03-24
申请号：US17544527
申请日：2021-12-07
发明人： Luke Gilbert , Felix Feng , Haolong Li
摘要： Methods and compositions are provided for screening candidate agents for inhibition of prostaglandin E synthase 3 (PTGES3) and anti-cancer activity against prostate cancer. In one aspect, a method of screening for a prostaglandin E synthase 3 (PTGES3) inhibitor for treating prostate cancer is provided, the method comprising: a) contacting PTGES3 with a candidate agent; and b) measuring inhibition of PTGES3 activity by the candidate agent. Screening assays may include determining the effectiveness of candidate PTGES3 inhibitors in reducing proliferation, survival, or androgen receptor abundance of prostate cancer cells.
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