公开(公告)号：US20240349734A1

公开(公告)日：2024-10-24

申请号：US18683618

申请日：2022-08-23

申请人： KAO CORPORATION

发明人： Takahiro HIOKI ,  Saki TAKAHIRA ,  Akihito KAWAHARA

IPC分类号： A01N63/50 ,  C12N9/64

CPC分类号： A01N63/50 ,  C12N9/6489 ,  C12Y304/24032

摘要： Provided are a rigid surface treatment agent capable of imparting an antibacterial property to a rigid surface, and a method for treating a rigid surface using the rigid surface treatment agent. The rigid surface treatment agent comprises, as an active component, a polypeptide which consists of an amino acid sequence of SEQ ID NO: 2, or a polypeptide which consists of an amino acid sequence having an identity of at least 80% with the amino acid sequence of SEQ ID NO: 2, and has activity of degrading a glycine-glycine bond in a peptide sequence.

公开(公告)号：US12050218B2

公开(公告)日：2024-07-30

申请号：US16476961

申请日：2018-01-12

申请人： NUtech Ventures

发明人： Srivatsan Kidambi ,  Oleh Khalimonchuk

IPC分类号： G01N31/00 ,  C07K16/30 ,  C12N9/64 ,  G01N33/53 ,  G01N33/574

CPC分类号： G01N33/57415 ,  C07K16/3015 ,  C12N9/6489 ,  G01N33/57484 ,  G01N2333/8146

摘要： The use of mitochondrial protease OMA1 as a theranostic marker for breast cancer, tumor progression, metastatis and drug responsiveness is disclosed herein.

公开(公告)号：US20240238390A1

公开(公告)日：2024-07-18

申请号：US17781947

申请日：2020-11-30

申请人： BCN PEPTIDES, S.A.

发明人： Jimena FERNÁNDEZ CARNEADO ,  Berta PONSATI ,  Antonio PARENTE DUEÑA ,  Mariona VALLÈS-MIRET ,  Josep FARRERA-SINFREU ,  Anna ALMAZÁN-MOGA ,  Josep ROMA-CASTANYER ,  Soledad GALLEGO MELCÓN ,  José SÁNCHEZ DE TOLEDO CODINA ,  Lucas MORENO MARTÍN-RETORTILLO ,  Natalia NAVARRO BAREA ,  Carla MOLIST MUÑOZ

IPC分类号： A61K38/48 ,  A61P35/00 ,  C12N9/64

CPC分类号： A61K38/4886 ,  A61P35/00 ,  C12N9/6489 ,  C12Y304/24

摘要： The present invention belongs to the field of biomedical chemistry and provides modified peptides and dimers thereof derived from the amino acid sequence of the protein ADAM-12, their compositions, process of synthesis and their use in medicine, specifically in the inhibition of cancer growth and/or the reduction or inhibition of cancer cell invasion and metastasis in different cancers.

公开(公告)号：US20240175000A1

公开(公告)日：2024-05-30

申请号：US18436552

申请日：2024-02-08

申请人： Kerry Group Services International Limited

发明人： Niall HIGGINS ,  Jacques GEORIS ,  Sara Llamas MOYA ,  Nathan MARSHALL ,  Derek CARR ,  Rachel MALONEY ,  Laura GUARAS

IPC分类号： C12N9/64 ,  A23K10/14 ,  A23K50/75 ,  C12N9/26 ,  C12N9/48

CPC分类号： C12N9/6489 ,  A23K10/14 ,  A23K50/75 ,  C12N9/2411 ,  C12N9/485 ,  C12N9/6424

摘要： An enzyme composition containing a protease combination or a protease mixture having neutral metalloprotease and serine alkaline protease activity, and an amylase. Feed compositions, additives and formulations containing the enzyme composition in methods for improving digestibility of proteins in an animal diet or animal feed, as well as optimizing the nutritional value of an animal diet or animal feed.

公开(公告)号：US20240166993A1

公开(公告)日：2024-05-23

申请号：US18451063

申请日：2023-08-16

申请人： Northwest Institute of Plateau Biology, CAS

发明人： Qi'en Yang ,  Ruidong Wan ,  Gongxue Jia ,  Shixin Wu ,  Yougui Fang

IPC分类号： C12N5/071 ,  C12N9/22 ,  C12N9/64

CPC分类号： C12N5/0612 ,  C12N9/22 ,  C12N9/6489

摘要： The present disclosure provides a method for separating SSCs from a frozen testicular tissue, and belongs to the field of cell biology. In the present disclosure, the method includes the following steps: resuscitating a frozen testicular tissue, digesting the resuscitated testicular tissue with a collagenase IV and a DNase I until seminiferous tubules are exposed and tube walls become coarse; washing the digested testicular tissue with a DPBS, conducting centrifugation and culture until cells migrate; collecting the migrated cells, and enriching and purifying SSCs. The method can maintain a milieu interieur of the SSCs to the greatest extent, and therefore cell viability, and less cell damages. Therefore, the method can be used for the separation of SSCs from frozen testicular tissues.

公开(公告)号：US11950578B2

公开(公告)日：2024-04-09

申请号：US17129708

申请日：2020-12-21

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Lynn Macdonald ,  Sean Stevens ,  Andrew J. Murphy ,  Margaret Karow

IPC分类号： C07K16/00 ,  A01K67/0275 ,  A01K67/0278 ,  B60H1/32 ,  C07K16/22 ,  C07K16/28 ,  C07K16/40 ,  C07K16/46 ,  C12N9/64 ,  C12N15/85

CPC分类号： A01K67/0278 ,  A01K67/0275 ,  B60H1/32281 ,  C07K16/22 ,  C07K16/28 ,  C07K16/2866 ,  C07K16/40 ,  C07K16/461 ,  C07K16/462 ,  C12N9/6489 ,  C12N15/8509 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/01 ,  C07K2317/21 ,  C07K2317/92 ,  C12N2800/204 ,  C12N2800/30

摘要： Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.

公开(公告)号：US20240101933A1

公开(公告)日：2024-03-28

申请号：US18496269

申请日：2023-10-27

申请人： The Procter & Gamble Company

发明人： Michelle JACKSON ,  Eva Maria PEREZ-PRAT de VINUESA ,  David John TARBIT ,  Philip Frank SOUTER ,  Lilia Maria BABE ,  David Aaron ESTELL ,  Frits GOEDEGEBUUR ,  Harm Jan MULDER ,  Sina PRICELIUS ,  Lydia DANKMEYER ,  Thijs KAPER ,  Hatice Billur ENGIN

IPC分类号： C11D3/386 ,  C11D3/20 ,  C11D3/22 ,  C11D3/33 ,  C11D3/39 ,  C12N9/26 ,  C12N9/28 ,  C12N9/64

CPC分类号： C11D3/386 ,  C11D3/2086 ,  C11D3/225 ,  C11D3/33 ,  C11D3/3905 ,  C12N9/2414 ,  C12N9/2417 ,  C12N9/6424 ,  C12N9/6489 ,  C12Y304/21062 ,  C12Y302/01001 ,  C12Y304/16 ,  C12Y304/17

摘要： A phosphate-free automatic dishwashing cleaning composition comprising i) a protease wherein the protease is a variant having at least 60% identity with the amino acid sequence of SEQ ID NO:1 and comprising at least one amino acid substitution (using the SEQ ID NO: 1 numbering) selected from the group consisting of X54T; X126A, D, G, V, E, K, I; X127E, S, T, A, P, G, C; and X128E, C, T, D, P, G, L, Y, N; and ii) from 10 to 50% by weight of the composition of a complexing agent system comprising from 0 to less than 30% by weight of the composition of citric acid.

公开(公告)号：US20230365960A1

公开(公告)日：2023-11-16

申请号：US18224418

申请日：2023-07-20

申请人： MicrobeDX, Inc. ,  The Regents of the University of California

发明人： Gabriel MONTI ,  Colin Wynn HALFORD ,  Alexandra PEREBIKOVSKY ,  Yujia LIU ,  Horacio KIDO ,  David Arnold HAAKE ,  Marc MADOU ,  Daniel GUSSIN ,  Bernard CHURCHILL

IPC分类号： C12N15/10 ,  C12N9/36 ,  C12N9/64

CPC分类号： C12N15/1003 ,  C12N9/2462 ,  C12N9/6489 ,  C12N2500/12 ,  C12Y302/01017 ,  C12Y304/24075

摘要： There is described a method for extracting a target chemical compound from a cellular material in a sample. The method comprising the steps of: subjecting the sample to mechanical lysis to cause disruption of a cellular membrane in the cellular material; contacting the sample with an alkaline material to produce a lysate composition comprising the target chemical compound; and recovering the lysate composition from the sample. There is also described a method for producing a lysate composition comprising RNA from a mammalian bodily fluid sample comprising a cellular material. There is also described a method for extracting a nucleic acid from a cellular material in a bodily fluid or an inoculant derived therefrom.

公开(公告)号：US11780904B2

公开(公告)日：2023-10-10

申请号：US17086072

申请日：2020-10-30

申请人： Takeda Pharmaceutical Company Limited

发明人： Leopold Grillberger ,  Manfred Reiter ,  Wolfgang Mundt

IPC分类号： C07K14/755 ,  C12N9/64 ,  A61K9/00 ,  A61K38/36 ,  A61K38/37 ,  C12P21/00 ,  A61K38/00

CPC分类号： C07K14/755 ,  A61K9/0019 ,  A61K38/36 ,  A61K38/37 ,  C12N9/6489 ,  C12P21/00 ,  A61K38/00 ,  C12N2500/24 ,  C12N2511/00 ,  C12Y304/24087

摘要： Among other aspects, the present invention relates to cell culture conditions for producing high molecular weight vWF, in particular, highly multimericWF with a high specific activity and ADAMTS13 with a high specific activity. The cell culture conditions of the present invention can include, for example, a cell culture medium with an increased copper concentration and/or cell culture supernatant with a low ammonium (NH4+) concentration. The present invention also provides methods for cultivating cells in the cell culture conditions to express high molecular weight vWF and rA13 having high specific activities.

公开(公告)号：US20230242896A1

公开(公告)日：2023-08-03

申请号：US17927474

申请日：2021-05-25

申请人： Sanquin IP B.V.

发明人： Johannes Jacobus VOORBERG ,  Nuno Alexandre GOMES GRAÇA ,  Bogaç ERÇIG

IPC分类号： C12N9/64 ,  A61P7/02

CPC分类号： C12N9/6489 ,  C12Y304/24087 ,  A61P7/02

摘要： The invention relates to ADAMTS13 protein variants comprising residues 1 to 685 of ADAMTS13 and wherein one or more N-linked glycosylation sites are added as compared to wild-type ADAMTS13 and/or one or more existing N-linked glycosylation sites are shifted as compared to wild-type ADAMTS13. The invention further relates to compositions comprising such ADAMTS13 variants, methods for their preparation and uses thereof, in particular as an antithrombotic agent, and in the treatment of thrombotic disease, thrombotic microangiopathy, thrombotic thrombocytopenic purpura (TTP), hemolytic—uremic syndrome (HUS), ischemic stroke, systemic thrombosis, COVID19, antiphospholipid syndrome, pre-eclampsia/HELLP syndrome, sepsis and sickle cell disease.