专利检索 ap:("The Regents of the University of California") AND inv:"Felix Feng" 第 1 页

1.

发明申请
Screening for Inhibitors of Prostaglandin E Synthase 3 Useful for Treatment of Prostate Cancer 有权

公开(公告)号：US20220091102A1

公开(公告)日：2022-03-24

申请号：US17544527

申请日：2021-12-07

申请人： The Regents of the University of California

发明人： Luke Gilbert , Felix Feng , Haolong Li

IPC分类号： G01N33/50 , C07K14/46 , C07K14/72

摘要： Methods and compositions are provided for screening candidate agents for inhibition of prostaglandin E synthase 3 (PTGES3) and anti-cancer activity against prostate cancer. In one aspect, a method of screening for a prostaglandin E synthase 3 (PTGES3) inhibitor for treating prostate cancer is provided, the method comprising: a) contacting PTGES3 with a candidate agent; and b) measuring inhibition of PTGES3 activity by the candidate agent. Screening assays may include determining the effectiveness of candidate PTGES3 inhibitors in reducing proliferation, survival, or androgen receptor abundance of prostate cancer cells.