公开(公告)号：US11905317B2

公开(公告)日：2024-02-20

申请号：US17311035

申请日：2019-12-05

Applicant: UBIO INC.

Inventor： Keun Nam Kim ,  Gun Won Bae ,  Jee Sun Hwang ,  Sun Myung Yoon

IPC: C07K14/435 ,  A61P29/00 ,  A61K8/64 ,  A61K8/98 ,  A61K38/17 ,  A61Q19/00

CPC classification number: C07K14/43572 ,  A61K8/64 ,  A61K8/987 ,  A61K38/1767 ,  A61P29/00 ,  A61Q19/00

Abstract: The present invention relates to a bee venom-purifying method comprising a virus clearance process and a composition for preventing or treating inflammatory disease by using same, the method comprising the steps of: (a) preparing a bee venom solution containing bee venom; (b) adjusting the pH of the bee venom solution prepared in step (a) into 2.0 to 4.0 by acid treatment to primarily deactivate viruses; and (c) filtering the pH-adjusted bee venom solution of step (b) through a nanofilter of 10 to 20 nm to secondarily remove viruses.

公开(公告)号：US20180355378A1

公开(公告)日：2018-12-13

申请号：US15780668

申请日：2015-12-04

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  TRUSTEES OF BOSTON UNIVERSITY ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Russell-John KROM ,  James J. COLLINS ,  Prerna Saluja BHARGAVA ,  Michael Andrew LOBRITZ

IPC: C12N15/86 ,  A61K35/76 ,  C07K14/245 ,  C07K14/435 ,  C07K14/46 ,  C12N15/70

CPC classification number: C12N15/86 ,  A61K35/76 ,  C07K14/245 ,  C07K14/43572 ,  C07K14/461 ,  C07K14/463 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74 ,  C12N2795/14132 ,  C12N2795/14143

Abstract: Provided herein, in some embodiments, are engineered phagemids that comprise at least one synthetic genetic circuit, wherein the at least one synthetic genetic circuit comprises gene sequences encoding at least one non-lytic antimicrobial peptides (AMPs) and/or antibacterial toxin proteins, a stable origin of replication, and a bacteriophage-packaging signal, wherein the engineered phagemid does not comprise some or all gene sequences encoding bacteriophage proteins required for assembly of a bacteriophage particle.

公开(公告)号：US10018618B2

公开(公告)日：2018-07-10

申请号：US15138048

申请日：2016-04-25

Applicant: Peptide BioSciences, Inc.

Inventor： Elliot Altman

IPC: C12N15/00 ,  C12N15/62 ,  G01N33/50 ,  C07K7/06 ,  C07K7/08 ,  C07K7/14 ,  C07K14/195 ,  C07K14/245 ,  C07K14/425 ,  C07K14/585 ,  C07K14/59 ,  C07K14/605 ,  C07K14/61 ,  C07K14/62 ,  C07K14/645 ,  C12N15/10 ,  C12N15/63 ,  C12N15/67 ,  C12N15/72 ,  C40B40/02 ,  G01N33/68 ,  C07K14/435 ,  C07K14/46 ,  C07K14/575 ,  C07K14/58 ,  C07K14/63 ,  C07K14/655 ,  C07K14/665 ,  A61K38/00

CPC classification number: G01N33/5008 ,  C07K7/06 ,  C07K7/08 ,  C07K7/14 ,  C07K14/195 ,  C07K14/245 ,  C07K14/425 ,  C07K14/435 ,  C07K14/43536 ,  C07K14/43568 ,  C07K14/43572 ,  C07K14/463 ,  C07K14/575 ,  C07K14/58 ,  C07K14/585 ,  C07K14/59 ,  C07K14/605 ,  C07K14/61 ,  C07K14/62 ,  C07K14/63 ,  C07K14/645 ,  C07K14/655 ,  C07K14/665 ,  C07K2319/00 ,  C12N15/1037 ,  C12N15/62 ,  C12N15/635 ,  C12N15/67 ,  C12N15/72 ,  C40B40/02 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/68 ,  G01N33/6845

Abstract: An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus identified are inherently protease- and peptidase-resistant. Also provided are bioactive peptides stabilized by a stabilizing group at the N-terminus, the C-terminus, or both. The stabilizing group can be a small stable protein, such as the Rop protein, glutathione sulfotransferase, thioredoxin, maltose binding protein, or glutathione reductase, an α-helical moiety, or one or more proline residues.

公开(公告)号：US20170218461A1

公开(公告)日：2017-08-03

申请号：US15412746

申请日：2017-01-23

Applicant: INSTITUTE OF APICULTURAL RESEARCH, CHINESE ACADEMY OF AGRICULTURAL SCIENCES

Inventor： Chao CHEN ,  Wei SHI ,  Zhiguang LIU ,  Xiao CHEN ,  Huihua WANG ,  Haikun GUO

IPC: C12Q1/68 ,  A01K67/033 ,  C07K14/435

CPC classification number: C12Q1/6888 ,  A01K67/033 ,  C07K14/43572 ,  C12Q2600/124 ,  C12Q2600/156

Abstract: The present invention relates to the field of biotechnology, in particular to genes and use thereof. The present invention employs whole genome sequencing to perform whole genome re-sequencing on a large number of individuals of the honey bee Apis mellifera sinisxinyuan, and obtains genes specific to the A. m. sinisxinyuan. The genes play important roles in the differentiation of A. m. sinisxinyuan from the honey bees in other regions and in the adaptive evolution of A. m. sinisxinyuan to the local environment. The Foxo gene or the Ebony gene provided in the present invention can be used to identify A. m. sinisxinyuan from other subspecies; can also be used for studying the genetic diversity of species resources of bees; and can further be used for studying cold resistance genes. This will fill the gap in the research field of A. m. sinisxinyuan by Chinese researchers.

公开(公告)号：US20170107256A1

公开(公告)日：2017-04-20

申请号：US15389802

申请日：2016-12-23

Applicant: UNIVERSITAET LEIPZIG

Inventor： Ralf Hoffmann ,  Daniel Knappe ,  Kai Hilpert ,  Ralf Mikut ,  Serge Ruden

IPC: C07K7/08 ,  C07K14/435

CPC classification number: C07K7/08 ,  A61K38/00 ,  A61K38/10 ,  C07K14/43572

Abstract: This invention relates to modified antibiotic peptides, particularly for use in medicine. The invention further relates to composite and methods for destroying microorganisms, such as bacteria, viruses or fungi, and to methods for treating microbial infections. The object of the invention is to develop novel antibiotic peptides, particularly having enhanced antibiotic activity and an expanded spectrum of activity against other strains of bacteria, particularly gram-positive bacteria such as Staphylococcus aureus. According to the invention, the object is attained in a first aspect by a peptide according to claim 1.

公开(公告)号：US09556228B2

公开(公告)日：2017-01-31

申请号：US14346624

申请日：2012-09-21

Applicant: Universitaet Leipzig

Inventor： Ralf Hoffmann ,  Daniel Knappe ,  Kai Hilpert ,  Ralf Mikut ,  Serge Ruden

IPC: C07K7/08 ,  A61K38/00 ,  A61K38/10

CPC classification number: C07K7/08 ,  A61K38/00 ,  A61K38/10 ,  C07K14/43572

Abstract: This invention relates to modified antibiotic peptides, particularly for use in medicine. The invention further relates to compositions and methods for destroying microorganisms, such as bacteria, viruses or fungi, and to methods for treating microbial infections. The object of the invention is to develop novel antibiotic peptides, particularly having enhanced antibiotic activity and an expanded spectrum of activity against other strains of bacteria, particularly gram-positive bacteria such as Staphylococcus aureus. According to the invention, the object is attained in a first aspect by a peptide according to claim 1.

Abstract translation: 根据本发明，在第一方面的目的是通过权利要求1的肽。

公开(公告)号：US20160032252A1

公开(公告)日：2016-02-04

申请号：US14783787

申请日：2014-04-15

Applicant: THE UNIVERSITY OF WARWICK

Inventor： David J. EVANS ,  Eugene RYABOV

IPC: C12N7/00 ,  C07K16/10 ,  C12N15/113 ,  A01K67/033 ,  C12Q1/70

CPC classification number: C12N7/00 ,  A01K67/0333 ,  A01K2217/05 ,  A01K2217/058 ,  A01K2227/706 ,  A01K2267/02 ,  C07K14/43572 ,  C07K16/1009 ,  C12N15/1131 ,  C12N15/8509 ,  C12N2310/14 ,  C12N2320/30 ,  C12N2770/00021 ,  C12N2770/32021 ,  C12N2770/32022 ,  C12N2830/75 ,  C12N2999/005 ,  C12Q1/6883 ,  C12Q1/701 ,  C12Q2600/124

Abstract: The invention is in the field of virology and relates to the deformed wing virus (DWV). A new strain of deformed wing virus (DWV) has been identified that is predominant in bees infested with Varroa mites. This particular strain of DWV can be used in diagnostics to identify at risk colonies. Also, inhibitors of the particular strain may be used in the treatment and/or prevention of DWV.

Abstract translation: 本发明涉及病毒学领域，涉及变形病毒（DWV）。 已经鉴定出一种新的变形病毒（DWV）菌株，它们是以瓦氏螨感染的蜜蜂为主。 DWV的这种特殊菌株可用于诊断，以鉴定危险的菌落。 而且，特定菌株的抑制剂也可用于DWV的治疗和/或预防。

公开(公告)号：US09193773B2

公开(公告)日：2015-11-24

申请号：US14206354

申请日：2014-03-12

Applicant: ANERGIS S.A.

Inventor： Francois Spertini ,  Blaise Corthesy

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/35 ,  A61K39/36 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K14/435 ,  C07K14/415

CPC classification number: A61K38/168 ,  A61K39/35 ,  C07K14/415 ,  C07K14/43531 ,  C07K14/43563 ,  C07K14/43572

Abstract: The present invention relates generally to in vivo methods and compositions designed for allergen specific immunotherapy. The compositions include contiguous overlapping peptide fragments which together form an entire amino acid sequence of an allergen.

Abstract translation: 本发明一般涉及设计用于变应原特异性免疫治疗的体内方法和组合物。 组合物包括连续重叠的肽片段，其一起形成变应原的完整氨基酸序列。

公开(公告)号：US08637037B2

公开(公告)日：2014-01-28

申请号：US12809503

申请日：2008-12-16

Applicant: Giovanni Mistrello ,  Daniela Roncarolo ,  Dario Zanoni ,  Paolo Falagiani

Inventor： Giovanni Mistrello ,  Daniela Roncarolo ,  Dario Zanoni ,  Paolo Falagiani

IPC: A61K39/00 ,  A61K39/35 ,  A61K39/36 ,  A61K39/38 ,  A23J1/00 ,  C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00

CPC classification number: A61K39/35 ,  C07K14/43572 ,  C12N9/16 ,  C12N9/20 ,  C12N9/2408

Abstract: The present invention concerns the preparation of purified allergens and allergoids, both derived from whole bee venom, for the desensitization (immunotherapy) of subjects affected by a specific allergy. In particular, the present invention concerns a preparation for immunotherapy based on purified bee venom, characterized in that said bee venom is essentially mellitin-free. In addition, the preparation of a monomeric allergoid obtainable through the carbamylation or thiocarbamylation reaction of said mellitin-free bee venom, is described. Said allergoid, being characterized by reduced IgE-binding activity, may be a safer and more effective candidate for specific immunotherapy.

Abstract translation: 本发明涉及由整个蜂毒衍生的纯化过敏原和过敏原的制备，用于受特定过敏影响的受试者的脱敏（免疫疗法）。 特别地，本发明涉及一种基于纯化的蜂毒素的免疫疗法的制备方法，其特征在于所述的蜂毒素基本上不含麦角蛋白。 此外，描述了通过所述不含蜂毒毒素的蜂毒素的氨基甲酰化或硫代氨基甲酰化反应获得的单体过敏物质的制备。 以IgE结合活性降低为特征的所述过敏性物质可能是特异性免疫治疗的更安全和更有效的候选物。

公开(公告)号：US08592651B2

公开(公告)日：2013-11-26

申请号：US11922048

申请日：2006-06-13

Applicant: Zhijian T. Li ,  Dennis J. Gray

Inventor： Zhijian T. Li ,  Dennis J. Gray

IPC: A01H5/00 ,  A01H1/06 ,  C12N15/82 ,  C07H21/04 ,  A01N63/00

CPC classification number: C12N15/8282 ,  A01N63/00 ,  A61K38/00 ,  C07K14/43563 ,  C07K14/43572 ,  C07K2319/00 ,  C07K2319/02 ,  C12N15/8286 ,  Y02A40/162

Abstract: The subject invention pertains to methods and materials for enhancing microbial resistance in plants. Specifically exemplified herein are grapevines transformed with polynucleotides that express a peptide which confers antimicrobial activity.