公开(公告)号：US20240327870A1

公开(公告)日：2024-10-03

申请号：US18580636

申请日：2022-07-22

申请人： SISAF LTD

发明人： Roghieh Suzanne SAFFIE-SIEBERT ,  Michael WELSH ,  Nasrollah TORABI-POUR

IPC分类号： C12N15/88 ,  A61K39/00 ,  A61K39/215 ,  A61K39/35

CPC分类号： C12N15/88 ,  A61K39/0008 ,  A61K39/0011 ,  A61K39/215 ,  A61K39/35 ,  A61K2039/53 ,  A61K2039/55555

摘要： A nucleic acid vector composition comprising: one or more enzymes and/or one or more fragments thereof; a nucleic acid; one or more particles comprising hydrolysable silicon; and one or more lipids. Also related products, medical uses, and methods.

公开(公告)号：US20240316187A1

公开(公告)日：2024-09-26

申请号：US18294951

申请日：2022-08-03

申请人： Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)

发明人： Erika VON MUTIUS ,  Bettina RANKL ,  Franz BRACHER ,  Christoph MÜLLER ,  Alesia WALKER ,  Stefanie HAUCK ,  Juliane MERL-PHAM ,  Heiko ADLER ,  Ali Önder YILDIRIM ,  Michael SATTLER ,  André SANTOS DIAS MOURÃO ,  Jan BORGGRÄFE ,  Patrick David O'CONNOR ,  Oliver PLETTENBURG

IPC分类号： A61K39/36 ,  A61K39/35 ,  A61P11/06 ,  A61P37/08

CPC分类号： A61K39/36 ,  A61K39/35 ,  A61P11/06 ,  A61P37/08

摘要： The present invention relates to a composition comprising proteins identified in barn dust extract or peptides derived from one of the proteins. The composition is useful in the prevention or treatment of a disease.

公开(公告)号：US20240307529A1

公开(公告)日：2024-09-19

申请号：US18370598

申请日：2023-09-20

申请人： THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Yoon Hong CHUN ,  Hyun Jong LEE ,  Kyung Sun NA ,  Ji An KIM

IPC分类号： A61K39/35 ,  A61K39/00 ,  A61K41/00 ,  A61P37/08

CPC分类号： A61K39/35 ,  A61K39/0003 ,  A61K41/0042 ,  A61P37/08 ,  A61K2039/6087 ,  A61K2039/6093

摘要： The present invention relates to a composition for immunotherapy of allergic diseases, comprising house dust mite antigens and hyaluronic acid hydrogels as active ingredients. By using hyaluronic acid as a material, and forming a crosslinking with the house dust mite antigens via a photoinitiator and visible light, it can overcome the disadvantage of easy degradation and simultaneously exploit biocompatible features. Moreover, it can provide a large amount of antigens to immune cells with a single administration, and despite this, it does not induce foreign body reactions, drug reactions, or immune responses, while generating excellent immune tolerance effects. Its safety is outstanding and it does not require repeated injections over a long period. Thus, it is expected to be useful as a preventive or therapeutic agent for allergic diseases induced by house dust mites.

公开(公告)号：US12085574B2

公开(公告)日：2024-09-10

申请号：US17147699

申请日：2021-01-13

申请人： BIOMEDICAL INTERNATIONAL R+D GMBH

发明人： Franziska Roth-Walter ,  Erika Jensen-Jarolim ,  Cristina Gomez-Casado ,  Araceli Diaz Perales ,  Luis Fernandez Pacios ,  Josef Singer

IPC分类号： A61K39/35 ,  A61K31/295 ,  A61K31/315 ,  A61K31/353 ,  A61K39/00 ,  A61K47/55 ,  C07K14/47 ,  G01N33/68 ,  G01N33/92

CPC分类号： G01N33/6893 ,  A61K31/295 ,  A61K31/315 ,  A61K31/353 ,  A61K39/35 ,  A61K47/551 ,  C07K14/47 ,  G01N33/6863 ,  G01N33/92 ,  A61K39/00 ,  G01N2800/24

摘要： Disclosed is a method for diagnosing allergy in a human or animal patient, wherein the level of species-specific lipocalin, especially lipocalin 2 in a human patient, is measured in a sample of said patient and wherein a lowered level of said lipocalin compared to the level of said lipocalin in the corresponding sample of a human or animal that has no allergy, is indicative of an allergy, as well as a kit for performing this method, and a kit for quality control of allergen molecules or extracts used for immunotherapy of allergy by determining its siderophore-iron ligand load and thus immunomodulatory potency. Further, lipocalin proteins for use in treatment or prevention of allergies are provided, preferably complexed with siderophore-iron ligands.

公开(公告)号：US20240252626A1

公开(公告)日：2024-08-01

申请号：US18633053

申请日：2024-04-11

申请人： Allovate, LLC

发明人： Michael Nelson ,  Erick Berglund

IPC分类号： A61K39/35 ,  A61K8/34 ,  A61K8/64 ,  A61K8/9728 ,  A61K8/9789 ,  A61K8/9794 ,  A61K8/98 ,  A61K39/00 ,  A61K49/00 ,  A61Q11/00

CPC分类号： A61K39/35 ,  A61K8/345 ,  A61K8/64 ,  A61K8/9728 ,  A61K8/9789 ,  A61K8/9794 ,  A61K8/981 ,  A61K8/985 ,  A61K8/987 ,  A61K49/0004 ,  A61Q11/00 ,  A61K2039/542 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2800/882 ,  A61K2800/92

摘要： Pro-toothpaste compositions formulated to receive a volume of allergen solution to provide toothpastes that exhibit efficacy for oral mucosal immunotherapy (OMIT) and acceptable consumer and product stability properties, along with kits of pro-toothpaste, allergen/extracts of allergens, and optionally compounding means and/or specialized toothbrushes are provided. Toothpastes suitable and effective for OMIT and methods for managing allergic symptoms and for reducing risk of allergy in people without symptoms employing the pro-toothpastes, toothpastes, and kits of the invention are also disclosed.

公开(公告)号：US20240230665A9

公开(公告)日：2024-07-11

申请号：US18497432

申请日：2023-10-30

申请人： Vanderbilt University

发明人： Scott A. SMITH

IPC分类号： G01N33/68 ,  A61K39/35 ,  A61K45/06 ,  C07K16/16 ,  C07K16/18 ,  G01N33/53

CPC分类号： G01N33/686 ,  A61K39/35 ,  A61K45/06 ,  C07K16/16 ,  C07K16/18 ,  G01N33/5308 ,  C07K2317/21 ,  G01N2333/43526 ,  G01N2333/43582

摘要： The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies.

公开(公告)号：US11980684B2

公开(公告)日：2024-05-14

申请号：US16761491

申请日：2018-11-05

申请人： CAMBRIDGE ALLERGY LIMITED

发明人： Robert Neil Ward ,  Ryan John Anthony Wilson ,  Michael John Frodsham

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K9/48 ,  A61K39/35

CPC分类号： A61K9/0053 ,  A61K9/1652 ,  A61K9/4858 ,  A61K39/35

摘要： This invention relates to an oral immunotherapy (OIT) composition comprising granules that contain an allergenic protein, such as peanut protein, along with a humectant, such as trehalose, and a binder, such as hypromellose. The composition may further comprise a filler, such as mannitol and a lubricant, such as stearic acid. OIT compositions, methods of preparing OIT compositions and methods of treatment of food allergy using OIT compositions are provided.

公开(公告)号：US20240133898A1

公开(公告)日：2024-04-25

申请号：US18546766

申请日：2022-02-24

申请人： Alladapt Immunotherapeutics, Inc.

发明人： Preeti Lal ,  Ashley Dombkowski ,  Dana McClintock

IPC分类号： G01N33/68 ,  A61K9/00 ,  A61K39/35 ,  A61K39/36 ,  A61P37/08

CPC分类号： G01N33/6893 ,  A61K9/0053 ,  A61K39/35 ,  A61K39/36 ,  A61P37/08 ,  G01N33/6854 ,  G01N33/6878 ,  A61K2039/70 ,  G01N2800/24 ,  G01N2800/52

摘要： The disclosure relates generally to methods of treating allergies in subjects, methods of monitoring treatment of allergies in subjects, methods of diagnosing allergies in subjects, methods for determining whether subjects are candidates for allergy treatments, methods and kits for detecting allergies or allergens, methods for identifying cross-reactive allergens, antibodies that bind allergenic proteins and methods of identifying the same, and multiple allergen compositions and methods of preparing the same.

公开(公告)号：US20240108719A1

公开(公告)日：2024-04-04

申请号：US18471906

申请日：2023-09-21

申请人： HOYU CO., LTD.

发明人： Kayoko Matsunaga ,  Akiko Yagami ,  Masashi Nakamura ,  Naoshi Shimojo ,  Nayu Sato ,  Yuji Aoki ,  Tomomi Sakai

IPC分类号： A61K39/35 ,  C07K14/435 ,  G01N33/68

CPC分类号： A61K39/35 ,  C07K14/43509 ,  G01N33/6854 ,  G01N2800/24

摘要： The present invention provides novel antigens of an allergy to shrimp, methods and kits for diagnosing an allergy to shrimp, pharmaceutical compositions comprising such an antigen, shrimps or processed products of shrimp in which such an antigen is eliminated, and a tester composition for determining the presence or absence of a shrimp antigen in an object of interest. The present invention also relates to polypeptides comprising an epitope of an antigen, kits, compositions and methods for diagnosing an allergy, comprising such a polypeptide, pharmaceutical compositions comprising such a polypeptide, and raw materials or processed products in which an antigen comprising such a polypeptide is eliminated or reduced. The present invention further relates to a tester composition for determining the presence or absence of an antigen in an object of interest.

公开(公告)号：US11931411B2

公开(公告)日：2024-03-19

申请号：US17523648

申请日：2021-11-10

申请人： DBV Technologies ,  Assistance Publique-Hôpitaux De Paris ,  Université Paris Cité

发明人： Christophe Dupont ,  Pierre-Henri Benhamou ,  Bertrand Dupont

IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K39/00 ,  A61K39/35 ,  A61K39/36

CPC分类号： A61K39/35 ,  A61K9/0014 ,  A61K9/7007 ,  A61K39/36 ,  A61K9/7023 ,  A61K2039/54 ,  A61K2039/545

摘要： The present application relates to a method for desensitization of allergic patients. More specifically it relates to an epicutaneous desensitization method, applicable to any type of allergens and of patients. The method of the invention is essentially non-invasive and does not require the use of adjuvants. Further, it may be easily applied and monitored by the actual patient.