公开(公告)号：US20240230665A9

公开(公告)日：2024-07-11

申请号：US18497432

申请日：2023-10-30

申请人： Vanderbilt University

发明人： Scott A. SMITH

IPC分类号： G01N33/68 ,  A61K39/35 ,  A61K45/06 ,  C07K16/16 ,  C07K16/18 ,  G01N33/53

CPC分类号： G01N33/686 ,  A61K39/35 ,  A61K45/06 ,  C07K16/16 ,  C07K16/18 ,  G01N33/5308 ,  C07K2317/21 ,  G01N2333/43526 ,  G01N2333/43582

摘要： The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies.

公开(公告)号：US20220220162A1

公开(公告)日：2022-07-14

申请号：US17148227

申请日：2021-01-13

申请人： Houshang Alizadeh ,  Fariba Rafiei ,  Ali-Akbar Shahnejat Bushehri

发明人： Houshang Alizadeh ,  Fariba Rafiei ,  Ali-Akbar Shahnejat Bushehri

IPC分类号： C07K14/415 ,  C12N9/24 ,  C12N9/64 ,  C12N9/96 ,  A61P35/00 ,  C07K16/16

摘要： A targeted delivery of recombinant therapeutic protein to inhibit the growth of cancer cells is disclosed. The recombinant protein derived from Abrin-a A-chain able to inhibit the growth of cancer cell and conjugated to stxB to form Abrin-f-stxB. The abrin toxin A chain and the Shiga toxin B chain are linked with the furin linker to form a recombinant therapeutic protein as chemotherapeutic agent to inhibit the growth of cancer cells. A conjugate for the delivery of a compound into cancer cells, comprising a first module mediates cell targeting and facilitates cellular uptake, a second module facilitates transport to the endoplasmic reticulum (ER), a third module mediates translocation from the ER to the cytosol and a compound that is desired to be delivered to the cytosol. The recombinant protein Abrin-f-stxB exhibits high binding affinity of stxB as a drug delivery system to Gb3 receptor in targeted cancer diagnosis and treatment.

公开(公告)号：US20220153820A1

公开(公告)日：2022-05-19

申请号：US17529513

申请日：2021-11-18

申请人： IgGenix, Inc.

发明人： Derek Croote

IPC分类号： C07K16/16 ,  C07K16/18 ,  C07K16/14 ,  C12N7/00

摘要： The invention generally relates to therapeutic compositions and methods for treating and suppressing allergic responses.

公开(公告)号：US11168335B2

公开(公告)日：2021-11-09

申请号：US16245767

申请日：2019-01-11

申请人： Wageningen Universiteit

发明人： Jacobus Hubertus Vossen ,  Kwang Ryong Jo ,  Richard Gerardus Franciscus Visser

IPC分类号： C12N15/82 ,  A01H5/06 ,  C07K14/415 ,  A01H1/02 ,  C07K16/16

摘要： A R8 phytophthora resistance gene from potato is described that produces a protein capable of inferring oomycete resistance, such as resistance to Phytophthora infestans when expressed in a plant. Also described is a method for providing at least partial resistance or increasing resistance in a plant against an oomycete infection comprising providing a plant or a part thereof with a nucleotide sequence of this gene or a functional fragment thereof, for example wherein said plant is a plant from the Solanaceae family, more preferably Solanum tuberosum.

公开(公告)号：US11131676B2

公开(公告)日：2021-09-28

申请号：US16079321

申请日：2017-02-24

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Armin Alaedini

IPC分类号： G01N33/50 ,  G01N33/68 ,  C07K16/16 ,  G01N33/53 ,  G01N33/92 ,  G01N33/564

摘要： The present invention provides a method of using increased levels of one or more biomarkers to identify subjects having non-celiac gluten sensitivity or non-celiac wheat sensitivity. The identification would aid the physician or health professional to determine a specific treatment for the patient, for example, a diet that eliminates wheat, rye, and/or barley. In one embodiment, the biomarkers are one or more of soluble CD 14 (sCD14), lipopolysaccharide-binding protein (LBP), anti-lipopolysaccharide antibodies, anti-flagellin antibodies, anti-gliadin antibodies, and intestinal fatty acid-binding protein (FABP2). The present invention also provides a method of using the same markers to monitor the response to treatment for non-celiac wheat sensitivity in a subject.

公开(公告)号：US10908168B2

公开(公告)日：2021-02-02

申请号：US16481165

申请日：2018-01-30

申请人： Vanderbilt University

发明人： Scott A. Smith

IPC分类号： A61K39/35 ,  A61K45/06 ,  C07K16/16 ,  C07K16/18 ,  G01N33/68 ,  G01N33/53

摘要： The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies.

公开(公告)号：US20190225675A1

公开(公告)日：2019-07-25

申请号：US16237877

申请日：2019-01-02

申请人： TUFTS UNIVERSITY

发明人： CHARLES B. SHOEMAKER

IPC分类号： C07K16/12 ,  C07K16/16 ,  C07K16/18

CPC分类号： C07K16/1282 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/1228 ,  C07K16/1278 ,  C07K16/16 ,  C07K16/18 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/40

摘要： Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant binding protein or a source of expression of the binding protein, wherein the binding protein neutralizes a disease agent that is a toxin, for example a Clostridium difficile toxin, a Shiga toxin, a ricin toxin, or an anthrax toxin.

公开(公告)号：US20190211068A1

公开(公告)日：2019-07-11

申请号：US16365900

申请日：2019-03-27

申请人： The Government of the United States of America, as represented by the Secretary of the Navy

发明人： Daniel Zabetakis ,  George P. Anderson ,  Ellen R. Goldman ,  Kendrick Turner ,  P. Audrey Brozozog Lee

IPC分类号： C07K14/47 ,  C07K16/16 ,  C07K16/12

CPC分类号： C07K14/47 ,  C07K16/1271 ,  C07K16/1278 ,  C07K16/16 ,  C07K2317/569 ,  C07K2317/94 ,  C07K2319/00

摘要： A single-domain antibody (sdAb) is produced by causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of α-synuclein. In embodiments, the protein is free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.

公开(公告)号：US10271546B2

公开(公告)日：2019-04-30

申请号：US15488843

申请日：2017-04-17

申请人： AGROSAVFE N.V.

发明人： Erik Jongedijk ,  Peter Verheesen

IPC分类号： A01N25/00 ,  C07K16/16 ,  A01N25/28 ,  A01N3/00 ,  A01N25/24 ,  A61K47/68

摘要： Described is the specific delivery of agrochemicals to plants. More specifically, a targeting agent has at least one binding domain that specifically binds to a binding site on an intact living plant. Such binding domains include a peptide having 4 framework regions and 3 complementary determining regions, or fragment(s) thereof, wherein the binding domains bind or retain a carrier onto a plant. Described are binding domains that specifically bind trichomes, stomata, cuticle, lenticels, thorns, spines, root hairs, or wax layer. Further described are methods for delivering agrochemicals to a plant, for depositing agrochemicals on a plant, and for retaining the agrochemicals on a plant, using targeting agents comprising the binding domains, and to methods for protecting a plant against stress or controlling plant growth. Also, described are methods for manufacturing a specifically targeting agrochemical carrier.

公开(公告)号：US20180346555A1

公开(公告)日：2018-12-06

申请号：US15994294

申请日：2018-05-31

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Jamie M. Orengo ,  Andrew J. Murphy ,  Ashok T. Badithe ,  Vishal Kamat ,  Yashu Liu

IPC分类号： C07K16/16 ,  A61P37/08

摘要： Provided herein are antibodies that bind Fagales allergens, Fagales related allergens, birch pollen, or Bet v 1, compositions comprising the antibodies, nucleic acids encoding the antibodies, and methods of using the antibodies. According to certain embodiments, the antibodies are fully human monoclonal antibodies that bind to Bet v 1. The antibodies are useful for binding Bet v 1 in vivo, thus preventing binding of the allergen to pre-formed IgE on the surface of mast cells or basophils. In doing so, the antibodies act to prevent the release of histamine and other inflammatory mediators from mast cells and/or basophils, thus ameliorating the untoward response to the Fagales allergens in sensitized individuals.