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公开(公告)号：US20220204583A1
公开(公告)日：2022-06-30
申请号：US17429602
申请日：2020-02-11
IPC分类号： C07K14/725 , A61K47/68 , C07K16/28
摘要： The present disclosure provides isolated polypeptides comprising variable lymphocyte receptors that specifically bind the blood brain barrier, compositions, and methods of use.
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2.发明申请公开(公告)号：US20170081385A1
公开(公告)日：2017-03-23
申请号：US15308535
申请日：2015-04-30
申请人： Emory University
IPC分类号： C07K14/725
CPC分类号： C07K14/7051 , C07K2319/30
摘要： This disclosure relates to variable lymphocyte receptors (VLRs) modifications such as humanized sequences and polypeptides comprising such sequences that specifically bind a target molecule and uses related thereto. In certain embodiments, the disclosure relates to recombinant polypeptide VLRs disclosed herein and variants thereof. In certain embodiments, this disclosure relates to treating or preventing a disease or condition comprising administering an effective amount of a recombinant poly-peptide or variant disclosed herein to a subject in need thereof.
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公开(公告)号：US10323077B2
公开(公告)日：2019-06-18
申请号：US15117811
申请日：2015-02-09
IPC分类号： C07K14/705 , A61K39/00 , C07K14/725 , C07K14/46 , A61K35/17 , A61K45/06 , C12N15/85 , A61K38/00 , A61K35/12
摘要： This disclosure relates to recombinant cellular expression of chimeric proteins with peptide sequences derived from lymphocyte receptors and uses for treating cancer. In certain embodiments, the disclosure relates to a recombinant vector comprising a nucleic acid that encodes a chimeric protein with a segment with a targeting moiety based on a variable lymphocyte receptor (VLR) capable of binding a tumor associated antigen and a segment with a T cell signal transduction subunit. In certain embodiments, the recombinant vectors are used in immune based cancer treatments.
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4.发明申请公开(公告)号：US20200308247A1
公开(公告)日：2020-10-01
申请号：US16857130
申请日：2020-04-23
申请人： Emory University
IPC分类号： C07K14/725
摘要： This disclosure relates to variable lymphocyte receptors (VLRs) modifications such as humanized sequences and polypeptides comprising such sequences that specifically bind a target molecule and uses related thereto. In certain embodiments, the disclosure relates to recombinant polypeptide VLRs disclosed herein and variants thereof. In certain embodiments, this disclosure relates to treating or preventing a disease or condition comprising administering an effective amount of a recombinant polypeptide or variant disclosed herein to a subject in need thereof.
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5.发明申请公开(公告)号：US20190202887A1
公开(公告)日：2019-07-04
申请号：US16183340
申请日：2018-11-07
申请人： Emory University
IPC分类号： C07K14/725
CPC分类号： C07K14/7051 , C07K2319/30
摘要： This disclosure relates to variable lymphocyte receptors (VLRs) modifications such as humanized sequences and polypeptides comprising such sequences that specifically bind a target molecule and uses related thereto. In certain embodiments, the disclosure relates to recombinant polypeptide VLRs disclosed herein and variants thereof. In certain embodiments, this disclosure relates to treating or preventing a disease or condition comprising administering an effective amount of a recombinant polypeptide or variant disclosed herein to a subject in need thereof.
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6.发明申请Expression of Chimeric Polypeptide with Variable Lymphocyte Receptors on Immune Cells and Uses for Treating Cancer 审中-公开具有可变淋巴细胞受体的嵌合多肽在免疫细胞上的表达和用于治疗癌症的用途公开(公告)号：US20170008947A1
公开(公告)日：2017-01-12
申请号：US15117811
申请日：2015-02-09
IPC分类号： C07K14/705 , C12N15/85 , A61K35/17 , C07K14/725 , C07K14/46 , A61K45/06
CPC分类号： C07K14/70521 , A61K35/17 , A61K38/00 , A61K45/06 , A61K2035/124 , C07K14/461 , C07K14/70503 , C07K14/7051 , C07K2319/02 , C07K2319/03 , C07K2319/33 , C07K2319/70 , C12N15/85
摘要： This disclosure relates to recombinant cellular expression of chimeric proteins with peptide sequences derived from lymphocyte receptors and uses for treating cancer. In certain embodiments, the disclosure relates to a recombinant vector comprising a nucleic acid that encodes a chimeric protein with a segment with a targeting moiety based on a variable lymphocyte receptor (VLR) capable of binding a tumor associated antigen and a segment with a T cell signal transduction subunit. In certain embodiments, the recombinant vectors are used in immune based cancer treatments.
摘要翻译： 本公开涉及嵌合蛋白与来自淋巴细胞受体的肽序列的重组细胞表达和用于治疗癌症的用途。 在某些实施方案中，本公开涉及包含编码嵌合蛋白的核酸的重组载体，所述核酸基于能够结合肿瘤相关抗原的可变淋巴细胞受体（VLR）和具有T细胞的区段的具有靶向部分的区段 信号转导亚基。 在某些实施方案中，重组载体用于基于免疫的癌症治疗。
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公开(公告)号：US11384134B2
公开(公告)日：2022-07-12
申请号：US16857130
申请日：2020-04-23
申请人： Emory University
IPC分类号： C07K14/46 , C12N15/00 , C07K14/725
摘要： This disclosure relates to variable lymphocyte receptors (VLRs) modifications such as humanized sequences and polypeptides comprising such sequences that specifically bind a target molecule and uses related thereto. In certain embodiments, the disclosure relates to recombinant polypeptide VLRs disclosed herein and variants thereof. In certain embodiments, this disclosure relates to treating or preventing a disease or condition comprising administering an effective amount of a recombinant polypeptide or variant disclosed herein to a subject in need thereof.
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公开(公告)号：US11136369B2
公开(公告)日：2021-10-05
申请号：US16400501
申请日：2019-05-01
IPC分类号： C07K14/705 , C07K14/725 , C07K14/46 , A61K35/17 , C12N15/85 , A61K45/06 , A61K38/00 , A61K35/12
摘要： This disclosure relates to recombinant cellular expression of chimeric proteins with peptide sequences derived from lymphocyte receptors and uses for treating cancer. In certain embodiments, the disclosure relates to a recombinant vector comprising a nucleic acid that encodes a chimeric protein with a segment with a targeting moiety based on a variable lymphocyte receptor (VLR) capable of binding a tumor associated antigen and a segment with a T cell signal transduction subunit. In certain embodiments, the recombinant vectors are used in immune based cancer treatments.
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9.发明申请公开(公告)号：US20190256574A1
公开(公告)日：2019-08-22
申请号：US16400501
申请日：2019-05-01
IPC分类号： C07K14/705 , C07K14/725 , C07K14/46 , A61K45/06 , A61K35/17 , C12N15/85
摘要： This disclosure relates to recombinant cellular expression of chimeric proteins with peptide sequences derived from lymphocyte receptors and uses for treating cancer. In certain embodiments, the disclosure relates to a recombinant vector comprising a nucleic acid that encodes a chimeric protein with a segment with a targeting moiety based on a variable lymphocyte receptor (VLR) capable of binding a tumor associated antigen and a segment with a T cell signal transduction subunit. In certain embodiments, the recombinant vectors are used in immune based cancer treatments.
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公开(公告)号：US10167330B2
公开(公告)日：2019-01-01
申请号：US15308535
申请日：2015-04-30
申请人： Emory University
IPC分类号： C07K14/705 , C07K14/725
摘要： This disclosure relates to variable lymphocyte receptors (VLRs) modifications such as humanized sequences and polypeptides comprising such sequences that specifically bind a target molecule and uses related thereto. In certain embodiments, the disclosure relates to recombinant polypeptide VLRs disclosed herein and variants thereof. In certain embodiments, this disclosure relates to treating or preventing a disease or condition comprising administering an effective amount of a recombinant polypeptide or variant disclosed herein to a subject in need thereof.
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