公开(公告)号：US20170008947A1

公开(公告)日：2017-01-12

申请号：US15117811

申请日：2015-02-09

Applicant: EMORY UNIVERSITY ,  CHILDREN'S HEATLHCARE OF ATLANTA, INC.

Inventor： H. Trent Spencer ,  Christopher B. Doering ,  Brantley R. Herrin ,  Max Dale Cooper

IPC: C07K14/705 ,  C12N15/85 ,  A61K35/17 ,  C07K14/725 ,  C07K14/46 ,  A61K45/06

CPC classification number: C07K14/70521 ,  A61K35/17 ,  A61K38/00 ,  A61K45/06 ,  A61K2035/124 ,  C07K14/461 ,  C07K14/70503 ,  C07K14/7051 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/33 ,  C07K2319/70 ,  C12N15/85

Abstract: This disclosure relates to recombinant cellular expression of chimeric proteins with peptide sequences derived from lymphocyte receptors and uses for treating cancer. In certain embodiments, the disclosure relates to a recombinant vector comprising a nucleic acid that encodes a chimeric protein with a segment with a targeting moiety based on a variable lymphocyte receptor (VLR) capable of binding a tumor associated antigen and a segment with a T cell signal transduction subunit. In certain embodiments, the recombinant vectors are used in immune based cancer treatments.

Abstract translation: 本公开涉及嵌合蛋白与来自淋巴细胞受体的肽序列的重组细胞表达和用于治疗癌症的用途。 在某些实施方案中，本公开涉及包含编码嵌合蛋白的核酸的重组载体，所述核酸基于能够结合肿瘤相关抗原的可变淋巴细胞受体（VLR）和具有T细胞的区段的具有靶向部分的区段 信号转导亚基。 在某些实施方案中，重组载体用于基于免疫的癌症治疗。

公开(公告)号：US20150140670A1

公开(公告)日：2015-05-21

申请号：US14411420

申请日：2013-03-15

Applicant: EMORY UNIVERSITY ,  THE US GOVERNMENT REPRESENTED BY THE SECT OF THE DEPT OF HEALTH AND HUMAN SCV/CENTERS FOR DISEASE ,  CHILDREN'S HEATLHCARE OF ATLANTA, INC. ,  GEORGIA TECH RESEARCH CORPORATION

Inventor： WIlbur A. Lam ,  Morgan Byrd ,  Erika Tyburski ,  Michael L. McKinnon ,  Siobhan O'Connor ,  Nathan A. Hotaling

IPC: G01N33/72

CPC classification number: G01N33/721 ,  A61B5/150022 ,  A61B5/150305 ,  A61B5/150343 ,  A61B5/150351 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/15105 ,  A61B5/157 ,  G01N2800/22

Abstract: Diagnostic kits and methods configured to rapidly and non-invasively determine physiologic levels of hemoglobin. A diagnostic kit may include a chamber pre-filled with an indicator, the indicator solution including a tetramethylbenzidine (TMB) solution, the indicator being configured to change color; a collection device configured to collect a test sample from a subject. The kit may also include a hemoglobin physiologic level identifier legend, the legend indicating 1) at least one color of the indicator and 2) a physiologic level and/or range of the hemoglobin and/or disease state associated with the color.

Abstract translation: 诊断试剂盒和方法配置为快速和非侵入性地测定血红蛋白的生理水平。 诊断试剂盒可以包括预填充有指示剂的室，指示剂溶液包括四甲基联苯胺（TMB）溶液，该指示剂被配置为改变颜色; 被配置为从受试者收集测试样本的收集装置。 该试剂盒还可以包括血红蛋白生理水平标识符图例，该图例表示1）指示剂的至少一种颜色，和2）与该颜色相关联的血红蛋白和/或疾病状态的生理水平和/或范围。