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公开(公告)号：US20210396722A1
公开(公告)日：2021-12-23
申请号：US17354296
申请日：2021-06-22
发明人： Michael O. Fogwill , Martin Gilar , Joseph D. Michienzi , Wade P. Leveille , Geoff C. Gerhardt , Jeffrey Musacchio , Jason F. Hill , Sylvain G. Cormier
摘要： Exemplary embodiments eliminate the need for column ovens in serial column chromatography arrangements and systems by using insulated sleeves. The insulated sleeves may encase individual chromatography columns or clusters of chromatography columns. The use of the insulated sleeves allows the chromatography columns to be positioned in close proximity to each other. This may decrease the overall size of a serial column chromatography arrangement and may reduce costs by not requiring the column ovens.
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公开(公告)号：US10092894B2
公开(公告)日：2018-10-09
申请号：US14194686
申请日：2014-03-01
发明人： Darryl W. Brousmiche , Jacob N. Fairchild , Jason F. Hill , Giorgis Isaac , Michael F. Morris , Kevin D. Wyndham
IPC分类号： B01J20/283 , B01J20/284 , B01J20/285 , B01J20/282 , B01J20/28 , C07F7/18 , B01D15/26 , B01J20/288 , B01D15/30 , B01D15/32 , B01D15/40 , B01D53/02 , B01J20/22 , B01J20/289 , B01J20/30 , B01J20/32
摘要： The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group.
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公开(公告)号：US09733222B2
公开(公告)日：2017-08-15
申请号：US14432313
申请日：2013-10-02
IPC分类号： B01J20/281 , B01J20/02 , B01J20/28 , B01J20/286 , B01J20/32 , B01J20/10 , B01D15/32 , B01D15/42 , G01N30/06 , G01N30/22 , B01J20/06 , B01J20/20 , G01N30/88 , G01N30/00
CPC分类号： G01N30/482 , B01D15/322 , B01D15/42 , B01J20/02 , B01J20/06 , B01J20/103 , B01J20/20 , B01J20/205 , B01J20/28069 , B01J20/28078 , B01J20/286 , B01J20/3251 , B01J20/3293 , B01J2220/58 , G01N30/06 , G01N30/22 , G01N2030/484 , G01N2030/8813 , G01N2333/575
摘要： The subject technology is directed to a CO2-based chromatography system and method for rapid determination of the levels and/or the presence or absence of steroids or steroid derivatives in a sample.
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公开(公告)号：US20210331138A1
公开(公告)日：2021-10-28
申请号：US17353096
申请日：2021-06-21
发明人： Kevin D. Wyndham , Michael F. Morris , Darryl W. Brousmiche , Jason F. Hill , Jacob N. Fairchild
IPC分类号： B01J20/283 , B01J20/32 , C07F7/18 , B01J20/288 , B01D15/26 , B01J20/28 , B01D15/30 , B01D15/32 , B01D15/40 , B01D53/02 , B01J20/22 , B01J20/289 , B01J20/30
摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.
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公开(公告)号：US20210023531A1
公开(公告)日：2021-01-28
申请号：US16926102
申请日：2020-07-10
发明人： Darryl W. Brousmiche , Jacob N. Fairchild , Jason F. Hill , Giorgis Isaac , Michael F. Morris , Kevin D. Wyndham
IPC分类号： B01J20/283 , B01J20/32 , C07F7/18 , B01J20/288 , B01D15/26 , B01J20/28 , B01D15/30 , B01D15/32 , B01D15/40 , B01D53/02 , B01J20/22 , B01J20/289 , B01J20/30
摘要： The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group. In some examples, the present disclosure can include a chromatographic system having a chromatographic column having a stationary phase with a chromatographic substrate containing silica, metal oxide, an inorganic-organic hybrid material, a group of block copolymers, or a combination thereof.
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公开(公告)号：US10265679B2
公开(公告)日：2019-04-23
申请号：US15911630
申请日：2018-03-05
发明人： Kevin D. Wyndham , Michael F. Morris , Darryl W. Brousmiche , Jason F. Hill , Jacob N. Fairchild
IPC分类号： B01J20/28 , B01J20/283 , C07F7/18 , B01D15/26 , B01J20/288 , B01J20/32 , B01D15/30 , B01D15/32 , B01D15/40 , B01D53/02 , B01J20/22 , B01J20/289 , B01J20/30 , B01J20/285 , B01J20/284 , B01J20/282
摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.
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公开(公告)号：US20180345248A1
公开(公告)日：2018-12-06
申请号：US16058069
申请日：2018-08-08
发明人： Darryl W. Brousmiche , Jacob N. Fairchild , Jason F. Hill , Giorgis Isaac , Michael F. Morris , Kevin D. Wyndham
IPC分类号： B01J20/283 , C07F7/18 , B01J20/28 , B01D15/30 , B01D15/32 , B01D15/40 , B01D53/02 , B01J20/22 , B01J20/32 , B01J20/30 , B01J20/289 , B01J20/288 , B01D15/26 , B01J20/282 , B01J20/285 , B01J20/284
CPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/32 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3234 , B01J20/3246 , B01J20/3285 , B01J20/3293 , B01J2220/54 , B01J2220/80 , C07F7/1804
摘要： The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group.
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公开(公告)号：US20180326324A1
公开(公告)日：2018-11-15
申请号：US15948666
申请日：2018-04-09
CPC分类号： B01D15/40 , B01D15/163 , G01N30/32 , G01N30/60 , G01N30/6039 , G01N30/8658 , G01N30/8668 , G01N30/8672 , G01N30/8693 , G01N2030/027 , G01N2030/8648
摘要： Methods for transferring a separation procedure from a first chromatographic system to a second one are disclosed that involve substantially matching a pressure profile. In some such methods, a length, an area, and a particle size of a first column in the first system and a flow rate in the first separation procedure are identifiable. Some such methods also involve selecting a combination of a length, an area, and a particle size of a second column in the second system and a flow rate for the second separation procedure. These methods may involve calculating a target length, a target area, or a target particle size for the second column in the second system or a target flow rate for the second separation procedure.
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公开(公告)号：US09925521B2
公开(公告)日：2018-03-27
申请号：US14401385
申请日：2013-05-15
发明人： Kevin D. Wyndham , Michael F. Morris , Darryl W. Brousmiche , Jason F. Hill , Jacob N. Fairchild
IPC分类号： B01J20/32 , B01J20/282 , B01J20/288 , B01J20/283 , B01D15/26 , B01J20/28 , B01D15/30 , B01D15/32 , B01D15/40 , B01D53/02 , B01J20/22 , B01J20/289 , C07F7/18 , B01J20/30 , B01J20/285 , B01J20/284
CPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/32 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3234 , B01J20/3246 , B01J20/3285 , B01J20/3293 , B01J2220/54 , B01J2220/80 , C07F7/1804
摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.
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公开(公告)号：US20150133294A1
公开(公告)日：2015-05-14
申请号：US14401385
申请日：2013-05-15
发明人： Kevin D. Wyndham , Michael F. Morris , Darryl W. Brousmiche , Jason F. Hill , Jacob N. Fairchild
IPC分类号： B01J20/289 , B01D53/02 , B01D15/30 , C07F7/18 , B01J20/28 , B01J20/32 , B01J20/22 , B01D15/26 , B01D15/40
CPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/32 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3234 , B01J20/3246 , B01J20/3285 , B01J20/3293 , B01J2220/54 , B01J2220/80 , C07F7/1804
摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≦(b/c)≦100, and a≧0.
摘要翻译： 一方面，本发明提供了用于由式1表示的各种不同色谱方式的色谱固定相材料：[X]（W）a（Q）b（T）c（式1）。 X可以是具有包含二氧化硅芯材料，金属氧化物芯材料，无机 - 有机杂化材料或其一组嵌段共聚物的表面的高纯度色谱芯组合物。 W可以不存在和/或可以包括氢和/或可以在X的表面上包括羟基.Q可以是在使用低水浓度的色谱条件下最小化随时间（漂移）的保留变化的官能团。 T可以包括与分析物色谱相互作用的一个或多个亲水性，极性的，可离子化的和/或带电的官能团。 另外，b和c可以是正数，其比例为0.05＆nlE;（b / c）＆nlE; 100，a≥0。
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