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公开(公告)号：US11992824B2
公开(公告)日：2024-05-28
申请号：US17353096
申请日：2021-06-21
发明人： Kevin D. Wyndham , Michael F. Morris , Darryl W. Brousmiche , Jason F. Hill , Jacob N. Fairchild
IPC分类号： B01J20/28 , B01D15/26 , B01D15/30 , B01D15/32 , B01D15/40 , B01D53/02 , B01J20/22 , B01J20/283 , B01J20/288 , B01J20/289 , B01J20/30 , B01J20/32 , C07F7/18 , B01J20/282 , B01J20/284 , B01J20/285
CPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3246 , B01J20/3285 , B01J20/3293 , C07F7/1804 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/32 , B01J20/3234 , B01J2220/54 , B01J2220/80
摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.
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公开(公告)号：US11376561B2
公开(公告)日：2022-07-05
申请号：US16591302
申请日：2019-10-02
发明人： Darryl W. Brousmiche , Kevin D. Wyndham , Nicole L. Lawrence , Jacob N. Fairchild , Bonnie A. Alden
摘要： Sorbents, devices, kits and methods useful for sample treatment are disclosed herein. In particular embodiments, described are inorganic/organic hybrid sorbent particles comprising (a) a core region that comprises a silica component and (b) a surface region that comprises an organic copolymer comprising at least one hydrophobic organic monomer and at least one hydrophilic organic monomer.
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公开(公告)号：US20190217273A1
公开(公告)日：2019-07-18
申请号：US16359328
申请日：2019-03-20
发明人： Kevin D. Wyndham , Michael F. Morris , Darryl W. Brousmiche , Jason F. Hill , Jacob N. Fairchild
IPC分类号： B01J20/283 , C07F7/18 , B01J20/28 , B01D15/26 , B01D15/30 , B01D15/32 , B01D15/40 , B01J20/288 , B01J20/32 , B01J20/289 , B01D53/02 , B01J20/22 , B01J20/30
CPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/32 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3234 , B01J20/3246 , B01J20/3285 , B01J20/3293 , B01J2220/54 , B01J2220/80 , C07F7/1804
摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.
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公开(公告)号：US20180259494A1
公开(公告)日：2018-09-13
申请号：US15914428
申请日：2018-03-07
发明人： Dimple D. Shah , Jacob N. Fairchild , Euan Ross , Benjamin Wuyts
IPC分类号： B01J20/281 , G01N30/74 , G01N30/72 , G01N30/86
CPC分类号： G01N30/482 , G01N30/72 , G01N30/74 , G01N30/8631 , G01N30/88 , G01N2030/027 , G01N2030/884 , G01N2033/184
摘要： The present disclosure relates to the determination of pesticides, e.g., polar pesticides, in a sample using chromatography. The present disclosure can provide direct analysis of polar pesticides, including anionic polar pesticides, using high performance liquid chromatography. The polar pesticides are sufficiently retained and resolved to allow for multiple polar pesticide determinations in a single analysis.
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公开(公告)号：US20230173406A1
公开(公告)日：2023-06-08
申请号：US18154360
申请日：2023-01-13
发明人： Kevin D. Wyndham , Jacob N. Fairchild , Pamela C. Iraneta , Stephen J. Shiner , Darryl W. Brousmiche , Daniel P. Walsh
IPC分类号： B01D15/08 , B01J20/283 , B01J20/28 , B01D15/32 , B01D15/40 , B01D15/30 , B01J20/32 , B01J20/286 , C07F7/12 , C07F7/18
CPC分类号： B01D15/08 , B01D15/40 , B01D15/305 , B01D15/322 , B01J20/283 , B01J20/286 , B01J20/3234 , B01J20/28004 , B01J20/28016 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28069 , B01J20/28071 , B01J20/28078 , B01J20/28083 , B01J20/28085 , C07F7/12 , C07F7/1804
摘要： The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are superficially porous chromatographic particulate materials comprising sized less than 2 microns.
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公开(公告)号：US11181103B2
公开(公告)日：2021-11-23
申请号：US16444180
申请日：2019-06-18
摘要： Described is a multi-stage pump having at least two stages. The multi-stage pump includes a first pump stage and a second pump stage each having a chamber of different diameter and volume. The multi-stage pump also includes a plunger having first and second plunger sections. The first plunger section has a first plunger diameter, a first end configured for coupling to a drive mechanism, and a second end opposite to the first end. The second plunger section has a second plunger diameter that is less than the first plunger diameter, a third end in contact with the second end of the first plunger, and a fourth end opposite the third end. Movement of the plunger produces a displacement volume for the first chamber that is different than a displacement volume produced for the second chamber. The multi-stage pump can be configured in different operational modes to provide different flow rates.
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公开(公告)号：US10092894B2
公开(公告)日：2018-10-09
申请号：US14194686
申请日：2014-03-01
发明人： Darryl W. Brousmiche , Jacob N. Fairchild , Jason F. Hill , Giorgis Isaac , Michael F. Morris , Kevin D. Wyndham
IPC分类号： B01J20/283 , B01J20/284 , B01J20/285 , B01J20/282 , B01J20/28 , C07F7/18 , B01D15/26 , B01J20/288 , B01D15/30 , B01D15/32 , B01D15/40 , B01D53/02 , B01J20/22 , B01J20/289 , B01J20/30 , B01J20/32
摘要： The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group.
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公开(公告)号：US09733222B2
公开(公告)日：2017-08-15
申请号：US14432313
申请日：2013-10-02
IPC分类号： B01J20/281 , B01J20/02 , B01J20/28 , B01J20/286 , B01J20/32 , B01J20/10 , B01D15/32 , B01D15/42 , G01N30/06 , G01N30/22 , B01J20/06 , B01J20/20 , G01N30/88 , G01N30/00
CPC分类号： G01N30/482 , B01D15/322 , B01D15/42 , B01J20/02 , B01J20/06 , B01J20/103 , B01J20/20 , B01J20/205 , B01J20/28069 , B01J20/28078 , B01J20/286 , B01J20/3251 , B01J20/3293 , B01J2220/58 , G01N30/06 , G01N30/22 , G01N2030/484 , G01N2030/8813 , G01N2333/575
摘要： The subject technology is directed to a CO2-based chromatography system and method for rapid determination of the levels and/or the presence or absence of steroids or steroid derivatives in a sample.
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9.发明申请公开(公告)号：US20160184736A1
公开(公告)日：2016-06-30
申请号：US14897584
申请日：2014-06-10
发明人： Kevin D. Wyndham , Jacob N. Fairchild , Pamela C. Iraneta , Stephen J. Shiner , Darryl W. Brousmiche , Daniel P. Walsh
IPC分类号： B01D15/08 , B01J20/28 , B01J20/283 , C07F7/18 , C07F7/12
摘要： The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are superficially porous chromatographic particulate materials comprising sized less than 2 microns.
摘要翻译： 本发明提供了新颖的色谱材料，例如用于色谱分离，其制备方法和含有色谱材料的分离装置; 分离装置，色谱柱和包含它们的试剂盒; 及其制备方法。 本发明的色谱材料是包含尺寸小于2微米的表面多孔色谱颗粒材料。
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公开(公告)号：US20240293799A1
公开(公告)日：2024-09-05
申请号：US18644518
申请日：2024-04-24
发明人： Kevin D. Wyndham , Michael F. Morris , Darryl W. Brousmiche , Jason F. Hill , Jacob N. Fairchild
IPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/32 , B01D15/40 , B01D53/02 , B01J20/22 , B01J20/28 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/288 , B01J20/289 , B01J20/30 , B01J20/32 , C07F7/18
CPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3246 , B01J20/3285 , B01J20/3293 , C07F7/1804 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/32 , B01J20/3234 , B01J2220/54 , B01J2220/80
摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.
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