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公开(公告)号：US11718643B2
公开(公告)日：2023-08-08
申请号：US14441129
申请日：2013-11-11
IPC分类号： B01D15/32 , B01D15/36 , B01D15/38 , B01J20/26 , B01J20/28 , B01J20/286 , B01J20/289 , B01J20/32 , B01J41/20 , C07K1/16 , C07K1/36 , C07K16/00 , C07K16/06 , G01N33/544
CPC分类号： C07K1/165 , B01D15/327 , B01D15/363 , B01D15/3847 , B01J20/265 , B01J20/286 , B01J20/289 , B01J20/28016 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J20/3285 , B01J41/20 , C07K1/36 , C07K16/00 , C07K16/065 , G01N33/544 , B01D15/3809 , B01D15/3885 , B01J2220/52 , B01J2220/80 , B01D15/363 , B01D15/327
摘要： The invention discloses a separation matrix which comprises a plurality of separation ligands, defined by the formula R1-L1-N(R3)-L2-R, immobilized on a support, wherein R1 is a five- or six-membered, substituted or non-substituted ring structure or a hydroxyethyl or hydroxypropyl group; L1 is either a methylene group or a covalent bond; R2 is a five- or six-membered, substituted or non-substituted ring structure; L2 is either a methylene group or a covalent bond; R3 is a methyl group; and wherein if R1 is a hydroxyethyl group and L1 is a covalent bond, R2 is a substituted aromatic ring structure or a substituted or non-substituted aliphatic ring structure.
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公开(公告)号：US20230149832A1
公开(公告)日：2023-05-18
申请号：US17937251
申请日：2022-09-30
申请人： NANOPAREIL, LLC
IPC分类号： B01D15/38 , B01J20/28 , G01N33/543 , B01D69/02 , B01D69/10 , B01D69/14 , B01D67/00 , B01J20/32
CPC分类号： B01D15/3828 , B01J20/28038 , G01N33/54353 , B01D69/02 , B01D69/1071 , B01D69/144 , B01D67/0002 , B01D67/00931 , B01J20/3255 , B01D2325/12 , B01D2325/36 , B01D2325/42 , B01D2325/38 , B01J20/3274 , B01D2323/36 , B01J2220/80 , B01J2220/54
摘要： The present disclosure provides surface functionalized affinity membranes. The surface functionalized affinity membranes can provide increased binding capacity through improved coupling chemistries, ligand densities, spacer arm types, and spacer arm lengths. Methods of preparing the surface functionalized affinity membranes and methods of using the surface functionalized affinity membranes to isolate targets of interest, including nucleic acid molecules and proteins, from a sample are also provided.
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公开(公告)号：US09644195B2
公开(公告)日：2017-05-09
申请号：US14723395
申请日：2015-05-27
发明人： Anjali Pandey , Jack W. Rose
IPC分类号： C07D221/06 , C12N9/64 , C07D213/72 , B01J20/26 , B01J20/286 , C07D213/75
CPC分类号： C12N9/6432 , B01J20/267 , B01J20/286 , B01J2220/80 , C07D213/72 , C07D213/75 , C12N9/6424 , C12Y304/21006
摘要： Disclosed herein are compounds, compositions, methods and kits for purifying a serine protease and serine proteases purified with the compounds, compositions and methods.
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公开(公告)号：US20170120232A1
公开(公告)日：2017-05-04
申请号：US15407240
申请日：2017-01-16
IPC分类号： B01J39/26 , B01J20/24 , B01D15/36 , C07K1/22 , B01D15/38 , B01D15/34 , B01J20/26 , B01J20/286
CPC分类号： B01J39/26 , B01D15/1864 , B01D15/34 , B01D15/361 , B01D15/362 , B01D15/3809 , B01J20/24 , B01J20/261 , B01J20/265 , B01J20/267 , B01J20/28014 , B01J20/28033 , B01J20/286 , B01J20/289 , B01J20/3085 , B01J20/3212 , B01J20/3278 , B01J20/3282 , B01J2220/80 , C07H1/08 , C07K1/22 , G01N2030/8827 , Y02P20/582
摘要： The invention discloses a method of separating a biomolecule from at least one other component in a liquid, comprising a step of contacting said liquid with a separation matrix comprising a solid support and polymer chains bound to said solid support. The polymer chains comprise units derived from a first monomer of structure CH2═CH-L-X, where L is a covalent bond or an alkyl ether or hydroxysubstituted alkyl ether chain comprising 2-6 carbon atoms, and X is a sulfonate or phosphonate group.
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5.发明授权Method for producing polymer particles, polymer particles, filler for chromatography column, and chromatography column 有权生产聚合物颗粒的方法，聚合物颗粒，色谱柱填料和色谱柱公开(公告)号：US09334353B2
公开(公告)日：2016-05-10
申请号：US14400698
申请日：2013-05-10
申请人： JSR Corporation
发明人： Sachiko Tsuda , Ryou Tsuda , Kouji Tamori
IPC分类号： A61K47/48 , C08F222/38 , B01J20/28 , B01J20/26 , B01J20/285 , B01D15/38 , B01J20/286 , B01J20/30 , C08G63/48
CPC分类号： C08F222/385 , B01D15/3804 , B01J20/261 , B01J20/267 , B01J20/28016 , B01J20/28059 , B01J20/285 , B01J20/286 , B01J20/3085 , B01J2220/80 , C08F220/54
摘要： To provide a method for producing polymer particles from an acrylamide monomer by a normal phase suspension polymerization method, polymer particles, a packing material for a chromatography column using the particles, and a chromatography column. A method for producing polymer particles, comprising dispersing a monomer composition comprising a multifunctional monomer having a plurality of N-substituted acrylamide groups in an aqueous medium; and polymerizing the dispersed monomer composition.
摘要翻译： 提供通过正相悬浮聚合法由丙烯酰胺单体制备聚合物颗粒的方法，聚合物颗粒，使用该颗粒的色谱柱的填充材料和色谱柱。 一种制备聚合物颗粒的方法，包括将含有多个N-取代的丙烯酰胺基团的多官能单体的单体组合物分散在水性介质中; 并使分散的单体组合物聚合。
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公开(公告)号：US09266826B2
公开(公告)日：2016-02-23
申请号：US14374569
申请日：2013-01-31
发明人： Kenji Hamase , Masashi Mita , Yousuke Toujo , Yukimitsu Suda
IPC分类号： C07C275/30 , B01J20/288 , B01J20/32 , C07C273/18 , B01J20/29 , B01D15/38
CPC分类号： C07C275/30 , B01D15/3833 , B01J20/286 , B01J20/288 , B01J20/29 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3244 , B01J20/3253 , B01J20/3261 , B01J20/3293 , B01J2220/4812 , B01J2220/58 , B01J2220/80 , C07B2200/07 , C07C273/1854
摘要： An embodiment of the present invention is a separating agent wherein a group represented by a chemical formula of: or a group represented by a chemical formula of: is introduced on a surface thereof.
摘要翻译： 本发明的一个实施方案是一种分离剂，其中由化学式表示的基团或由化学式表示的基团引入其表面。
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公开(公告)号：US20150337285A1
公开(公告)日：2015-11-26
申请号：US14723395
申请日：2015-05-27
发明人： Anjali Pandey , Jack W. Rose
IPC分类号： C12N9/64 , B01J20/26 , B01J20/286 , C07D213/72
CPC分类号： C12N9/6432 , B01J20/267 , B01J20/286 , B01J2220/80 , C07D213/72 , C07D213/75 , C12N9/6424 , C12Y304/21006
摘要： Disclosed herein are compounds, compositions, methods and kits for purifying a serine protease and serine proteases purified with the compounds, compositions and methods.
摘要翻译： 本文公开了用于纯化丝氨酸蛋白酶和用化合物，组合物和方法纯化的丝氨酸蛋白酶的化合物，组合物，方法和试剂盒。
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公开(公告)号：US20150182943A1
公开(公告)日：2015-07-02
申请号：US14416381
申请日：2013-07-08
申请人： DAICEL CORPORATION
发明人： Toru Shibata , Satoshi Shinkura
IPC分类号： B01J20/285 , C08G63/00 , C08G63/183 , B01J20/28 , B01J20/26
CPC分类号： B01J20/285 , B01D15/40 , B01J20/262 , B01J20/264 , B01J20/28016 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/286 , B01J20/3204 , B01J20/3272 , B01J2220/80 , C08G63/00 , C08G63/183
摘要： An object of the present invention is to provide a stationary phase that increases the number of column stages and that exhibits an excellent molecular discrimination ability. It was discovered that the number of column stages can be increased and an excellent molecular discrimination ability can be realized by a stationary phase that contains a polymer having, in main chain repeat units, an aromatic ring that forms a portion of the main chain and a bipolar atomic group that forms a portion of the main chain, wherein the stationary phase has a specific surface area of 5 to 1000 m2/g.
摘要翻译： 本发明的目的是提供一种固定相，其增加了柱级数并表现出优异的分子识别能力。 已经发现，可以增加柱级数，并且通过含有在主链重复单元中具有形成主链的一部分的芳环的聚合物的固定相可以实现优异的分子鉴别能力， 形成主链部分的双极原子团，其中固定相的比表面积为5〜1000m2 / g。
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公开(公告)号：US20150133618A1
公开(公告)日：2015-05-14
申请号：US14396207
申请日：2013-04-22
CPC分类号： B01J39/26 , B01D15/1864 , B01D15/34 , B01D15/361 , B01D15/362 , B01D15/3809 , B01J20/24 , B01J20/261 , B01J20/265 , B01J20/267 , B01J20/28014 , B01J20/28033 , B01J20/286 , B01J20/289 , B01J20/3085 , B01J20/3212 , B01J20/3278 , B01J20/3282 , B01J2220/80 , C07H1/08 , C07K1/22 , G01N2030/8827 , Y02P20/582
摘要： The invention discloses a method of separating a biomolecule from at least one other component in a liquid, comprising a step of contacting said liquid with a separation matrix comprising a solid support and polymer chains bound to said solid support. The polymer chains comprise units derived from a first monomer of structure CH2═CH-L-X, where L is a covalent bond or an alkyl ether or hydroxysubstituted alkyl ether chain comprising 2-6 carbon atoms, and X is a sulfonate or phosphonate group.
摘要翻译： 本发明公开了一种从液体中的至少一种其它组分分离生物分子的方法，包括使所述液体与包含固体支持物和与所述固体支持物结合的聚合物链的分离基质接触的步骤。 聚合物链包含衍生自结构为CH 2 = CH-L-X的第一单体的单元，其中L为共价键或包含2-6个碳原子的烷基醚或羟基取代的烷基醚链，X为磺酸盐或膦酸酯基团。
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公开(公告)号：US20150087816A1
公开(公告)日：2015-03-26
申请号：US14387363
申请日：2013-03-21
申请人： ZEOCHEM AG
发明人： Nicola Forrer , Mandy Erdmann , David Gétaz , Massimo Morbidelle , Susanna Bernardi , Rushd Khalaf
IPC分类号： B01J20/288 , C07F7/18 , C07K1/20
CPC分类号： B01J20/288 , B01D15/325 , B01J20/287 , B01J20/3257 , B01J2220/80 , C07F7/1804 , C07K1/20
摘要： A material for reverse phase chromatography comprises surface modifying apolar and charged groups bound to a solid support, said charged groups being present in amounts of about 0.25 to about 22% of the surface modifying groups, or in amounts of about 0.01 μmol/m2 to 0.8 μmol/m2 referred to the surface of the solid support for a material with a total amount of surface modifying groups of 3.6 μmol/m2. Such material and suitable purification conditions for active pharmaceutical ingredients (APIs) like peptides can be evaluated by (a) determining the isoelectric point (pI) of the API of interest, (b) choosing a pH in a range where the solid phase material is stable, (c) determining the difference pI-pH and (d) if the difference pI-pH is positive, choosing an anion exchange (AIEX) material, or if the difference pI-pH is negative, choosing an cation exchange (CIEX) material.
摘要翻译： 用于反相色谱的材料包括与固体支持物结合的表面改性非极性和带电基团，所述带电基团以约0.25至约22％的表面改性基团的量存在，或以约0.01μmol/ m 2至0.8的量存在 μmol/ m2表示固体支持物的表面，其表面改性基团的总量为3.6μmol/ m 2。 可以通过（a）测定目标API的等电点（pI），（b）选择在固相物质为的范围内的pH值来评估这样的物质和用于活性药物成分（API） 稳定，（c）确定差异pI-pH和（d）如果差异pI-pH为正，选择阴离子交换（AIEX）材料，或者如果差异pI-pH为负，则选择阳离子交换（CIEX） 材料。
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