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公开(公告)号：US10004698B2
公开(公告)日：2018-06-26
申请号：US14888185
申请日：2014-05-05
Applicant: Sree Chitra Tirunal Institute for Medical Sciences and Technology , Indian Council of Medical Research
Inventor： Lissy Kalliyana Krishnan , Lakshmi Sreedharam Pillai
CPC classification number: A61K31/12 , A61K9/006 , A61K9/19 , A61K9/7007 , A61K47/42
Abstract: Provided herein is a drug delivery system for curcumin comprising fibrinogen, thrombin and curcumin.
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2.发明公开公开(公告)号：US20230181751A1
公开(公告)日：2023-06-15
申请号：US17925385
申请日：2021-05-12
Inventor： Lissy Kalliyana KRISHNAN , Renjith Parameswaran NAIR , Mejo Chiratteparambil KORAH , Deepa SATHEE
CPC classification number: A61K47/643 , A61K9/19
Abstract: A formulation of pure dimethoxy curcumin-human serum albumin (DMCHSA) comprising a pure di-methoxy curcumin (DMC) bound to human serum albumin (HSA), wherein molar ratio of DMC to HSA is in the range of 3.0-6.0. Further, there is provided a highly soluble and safe intravenous formulation of pure dimethoxy curcumin-human serum albumin retaining proven biological activities and a process for the preparation thereof. Even further, there is provided a process for preparing formulation of pure dimethoxy curcumin-human serum albumin (DMCHSA) by preferential binding of DMC to HSA, which excludes other curcuminoids such as Demethoxy curcumin (DeMC) and Bidemethoxy curcumin (BiDeMC) present in the added chemical, increasing the purity of 80% DMC in starting raw material to >99% in the product DMCHSA.
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公开(公告)号：US20220177533A1
公开(公告)日：2022-06-09
申请号：US17266898
申请日：2019-08-08
Inventor： THEKKUVEETTIL Kumar Anoop , Salini BHASKER , Geethu SHAJI
IPC: C07K14/495 , C12N15/70 , A61P17/02
Abstract: In one aspect of the invention, the present invention discloses and claims a recombinant transforming growth factor alpha (TGF α) consisting of Sequence ID No.: 1, craving out from the whole TGF α, and cloned for the wound healing applications. Further it discloses primers for amplifying TGF α consisting of Sequence ID Nos.: 2 and 3, wherein sequence ID No.: 2 is forward primer, and the sequence ID No.: 3 is reserve primer for TGF α. It further discloses a process of preparation of a vector comprising essentially of Sequence ID No.: 1, said process comprising the steps of multiplying the desired gene fragment through PCR using primers of Sequence ID No.: 2 and 3. Further, a pharmaceutical composition comprising essentially of Sequence ID No.: 1, along with additives, fillers and addendums is disclosed. Finally, it discloses a method of wound healing using the recombinant TGF α comprising application of a pharmaceutical composition.
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公开(公告)号：US20220023497A1
公开(公告)日：2022-01-27
申请号：US17311879
申请日：2020-01-10
Inventor： Roy JOSEPH , Praveen Kunjan SOBHAN
Abstract: A 3D bioprintable ink formulation capable of multidimensional printing comprises gelatin modified by an essential amino acid arginine, oxidized alginate and a catalyst.
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公开(公告)号：US11911302B2
公开(公告)日：2024-02-27
申请号：US17285771
申请日：2019-12-19
Inventor： Sujesh Sreedharan , Anku Sreekumar , Sreehari Unnikrishnan Nair
CPC classification number: A61F2/90 , A61F2/06 , A61F2002/068 , A61F2002/823 , A61F2250/0039 , A61F2250/0098
Abstract: A flow diverter device is used to redirect the blood flow inside the cerebral blood vessels and for the reduction of blood flow to the aneurysm, hence preventing the chance of aneurysm rupture as well as promoting the healing of the aneurysm. The novel design of the device, using a set of thicker wires, provides high kink resistance and radial strength. Two patterns of inter-braiding the thicker set of wires with the finer braid are disclosed, one having a checker-board and the other a ring structure. Both patterns are highly kink resistant with the checker-board design providing minimal loss in flexibility, whereas the ring design provides greater radial strength. The device could be made of super elastic materials like Nitinol wires with the thicker set being radio opaque. The device is highly kink resistant and sufficiently flexible for use in vasculature with complex bends.
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Patent Agency Ranking
公开(公告)号：US20210386566A1
公开(公告)日：2021-12-16
申请号：US17285771
申请日：2019-12-19
Inventor： Sujesh SREEDHARAN , Anku SREEKUMAR , Sreehari Unnikrishnan NAIR
Abstract: A flow diverter device is used to redirect the blood flow inside the cerebral blood vessels and for the reduction of blood flow to the aneurysm, hence preventing the chance of aneurysm rupture as well as promoting the healing of the aneurysm. The novel design of the device, using a set of thicker wires, provides high kink resistance and radial strength. Two patterns of inter-braiding the thicker set of wires with the finer braid are disclosed, one having a checker-board and the other a ring structure. Both patterns are highly kink resistant with the checker-board design providing minimal loss in flexibility, whereas the ring design provides greater radial strength. The device could be made of super elastic materials like Nitinol wires with the thicker set being radio opaque. The device is highly kink resistant and sufficiently flexible for use in vasculature with complex bends.
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7.发明申请公开(公告)号：US20210251618A1
公开(公告)日：2021-08-19
申请号：US17253443
申请日：2018-10-10
Inventor： Sujesh SREEDHARAN , Jijo JERARD , Liji Geetha VIJAYAN , Bijulal SASIDHARAN
Abstract: The present invention relates to a device (D) for occluding atrial septal defect. Non-woven wires are introduced in one or more stages, with each stage interspaced with one or more braids and braided together with the wires from the woven centre and earlier stages to form the device (D). The transcatheter device (D) has two discs (101, 102) one a hub-less disc incorporating a woven central section on the left atrial side and the other disc on the right atrial side with a connecting neck (110) braided from wires. The device (D) has thrombogenic material in either discs (101, 102). A ridge (108) is configured on the periphery of either the left atrial disc or right atrial disc or both discs to improve structural stability of the device and provides enhanced elapsing force onto the septum reducing chances of migration.
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公开(公告)号：US11986571B2
公开(公告)日：2024-05-21
申请号：US17291075
申请日：2020-04-01
Inventor： Roy Joseph , Jayadevan Enakshy Rajan , Gopika Valsalakumari Gopan
CPC classification number: A61L24/001 , A61L24/0015 , A61L24/06 , A61L2300/106 , A61L2300/418 , A61L2430/36
Abstract: The invention relates to radiopaque liquid embolic composition comprising tetra iodo compound, 4,4-bis (4-hydroxy-3,5 diiodo phenyl) valeric acid (IBHV) of Formula I, covalently linked to ethylene vinyl alcohol copolymer (EVOH) and dissolved in a water miscible organic liquid.
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公开(公告)号：US20210402051A1
公开(公告)日：2021-12-30
申请号：US17291075
申请日：2020-04-01
Inventor： Roy JOSEPH , Jayadevan ENAKSHY RAJAN , Gopika VALSALAKUMARI GOPAN
Abstract: The invention relates to radiopaque liquid embolic composition comprising tetra iodo compound, 4,4-bis (4-hydroxy-3,5 diiodo phenyl) valeric acid (IBHV) of Formula I, covalently linked to ethylene vinyl alcohol copolymer (EVOH) and dissolved in a water miscible organic liquid.
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10.发明申请公开(公告)号：US20210322225A1
公开(公告)日：2021-10-21
申请号：US16959143
申请日：2018-12-26
Abstract: This invention relates to a lint free absorbent wound dressing, comprising a plasticized blend of a natural biopolymer and poly vinyl alcohol mixed in an acidic solvent which is neutralized and crosslinked using green crosslinking buffer system, finding application in exudating and bleeding wounds.
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